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Pain Science in Practice (Part 3):Peripheral Sensitization.

, 2022
In most cases, tissue injuries lead to inflammation and sensitization. From a neuroscience perspective, this is why one usually hurts when one is injured.
Hoegh, Morten; id_orcid
core   +1 more source

Peripheral Sensitivity to Steroids Revisited

Physiological Research, 2017
Resistance to steroid hormones presents a serious problem with respect to their mass use in therapy. It may be caused genetically by mutation of genes involved in hormonal signaling, not only steroid receptors, but also other players in the signaling cascade as co-regulators and other nuclear factors, mediating the hormone-born signal.
R, Hampl, K, Vondra
openaire   +2 more sources

TET1-TRPV4 Signaling Contributes to Bone Cancer Pain in Rats

Brain Sciences, 2023
Bone cancer pain (BCP) is excruciating for cancer patients, with limited clinical treatment options and significant side effects, due to the complex and unclear pathogenesis of bone cancer pain.
Zhen-Hua Xu, Zheng Niu, Yun Liu, Pei-Lin Liu, Xiao-Long Lin, Ling Zhang, Long Chen, Yu Song, Ren Sun, Hai-Long Zhang   +9 more
doaj   +1 more source

Trends in cutaneous sensitization in the first 18 years of life: results from the 1989 Isle of Wight birth cohort study [PDF]

, 2012
Background:Skin prick testing (SPT) is fundamental to the practice of clinical allergy identifying relevant allergens and predicting the clinical expression of disease.
Raza, A., Karmaus, W., Arshad, S.H., Arshad, S. H., Roberts, G., Kurukulaaratchy, R.J., Dean, T., Raza, Abid, Arshad, S., Kurukulaaratchy, R., Arshad, Syed Hasan, Scott, M., Matthews, S., Kurukulaaratchy, R. J., Dean, Taraneh, Zhang, H., Kurukulaaratchy, Ramesh, Dean, Tara   +17 more
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Acute pain and peripheral sensitization following cautery disbudding in 1- and 4-week-old calves [PDF]

, 2018
Acute pain and peripheral sensitization development after cautery disbudding was investigated in 33 calves administered preventive multimodal analgesia. The animals were assigned randomly to three groups: 1) Group SH (Control), undergoing sham disbudding
Spadavecchia, Claudia, Bruckmaier, Rupert, Andreas, Gutzwiller, Mirra, Alessandro, Casoni, Daniela   +4 more
core   +1 more source

Peripheral Mechanisms of Neuropathic Pain—The Role of Neuronal and Non-Neuronal Interactions and Their Implications for Topical Treatment of Neuropathic Pain

Pharmaceuticals, 2021
Neuropathic pain in humans arises as a consequence of injury or disease of somatosensory nervous system at peripheral or central level. Peripheral neuropathic pain is more common than central neuropathic pain, and is supposed to result from peripheral ...
Magdalena Kocot-Kępska, Renata Zajączkowska, Joanna Mika, Jerzy Wordliczek, Jan Dobrogowski, Anna Przeklasa-Muszyńska   +5 more
doaj   +1 more source

CHRONIC BACK PAIN: FROM PATHOGENETIC CONCEPTS TO THERAPEUTIC STRATEGIES

Медицинский совет, 2017
Social losses and expenses of healthcare resources related to chronic back pain continue remaining a high burden for the society. The mechanism of the central sensitization partially accounts for the formation of the chronic back pain, but these ...
O. V. Vorobieva
doaj   +1 more source

Guidance on Community-Led Sensitization

, 2021
This template tool on community-led sensitization forms part of the Resource Pack on Community-Based Protection. The document discusses the topics advocacy, listening clubs, material support, radio, referrals, sensitization and theatre.

core   +1 more source

Preserved cellular immunity in smoldering acute leukemia [PDF]

, 1976
"Smoldering acute leukemia", a variant of acute myelogenous leukemia, has been recognized with frequent incidence in recent years. This is chracterized by benign clinical course, poor physical findings, leukopenia and mild anemia in the ...
Hironobu Toki, Toki, Hironobu
core   +1 more source

The Complexity of Neuropathic Pain and Central Sensitization: Exploring Mechanisms and Therapeutic Prospects

Journal of Integrative Neuroscience
Neuropathic pain is a common pain syndrome, which seriously affects the quality of life of patients. The mechanism of neuropathic pain is complex. Peripheral tissue injury can trigger peripheral sensitization; however, what really plays a key role is the
Yan-chao Ma, Ze-biao Kang, Yong-qiang Shi, Wen-yi Ji, Wen-ming Zhou, Wei Nan   +5 more
doaj   +1 more source