Results 161 to 170 of about 209,971 (329)

CALR Type 1‐Like Mutations Increase Endoplasmic Reticulum Free Ca2+ and Induce ERK1/2 Activation Independent of Thrombopoietin Receptor Activation

Cell Biology International, EarlyView.
ABSTRACT Calreticulin is a multifunctional protein found in the endoplasmic reticulum lumen that is important for calcium homeostasis and glycoprotein folding. Mutations in exon 9 of the CALR gene are the second most common genetic cause of myeloproliferative neoplasms.
Mifra Faiz, Caitlin Dunstan‐Harrison, Elizabeth C. Ledgerwood   +2 more
wiley   +1 more source

Apoptotic Rate in Peripheral T-Cell Lymphomas [PDF]

, 2002
George Z. Rassidakis, Dan Jones, Athanasios Thomaides, Filiz Şen, Raymond Lai, Fernando Cabanillas, Timothy J. McDonnell, L. Jeffrey Medeiros   +7 more
openalex   +1 more source

Expert Perspective: Hematologic Malignancies and Vasculitis

Arthritis &Rheumatology, EarlyView.
Michelle L. Robinette, Hetty E. Carraway
wiley   +1 more source

Effect of Mild to Moderate Hepatic Impairment on Valemetostat Pharmacokinetics: An Open‐Label, Phase I Study

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Valemetostat tosylate (valemetostat) is a dual inhibitor of enhancer of zeste homolog (EZH) 2 and EZH1, approved in Japan for the treatment of relapsed/refractory peripheral T‐cell lymphoma and adult T‐cell leukemia/lymphoma. This Phase I, open‐label study evaluated the pharmacokinetics and safety of a single 50‐mg oral dose of valemetostat in
Masaya Tachibana, Thuy Vu Craveiro, Thomas C. Marbury, Samuel Oberstein, George J. Atiee, Ben Tao, Takako Shimizu, Yvonne Lau, Malaz A. Abutarif   +8 more
wiley   +1 more source

Characterization of T-Cell Subpopulations in Skin and Peripheral Blood of Patients with Cutaneous T-Cell Lymphomas and Benign Inflammatory Dermatoses

, 1983
Rein Willemze, Claire B. De Graaff-Reitsma, J. Cnossen, W.A. van Vloten, Chris J.L.M. Meijer   +4 more
openalex   +1 more source

Peripheral T-Cell Lymphoma Mimicking Marginal Zone B-Cell Lymphoma [PDF]

, 2002
Patricia Uherova, Charles W. Ross, William G. Finn, Timothy P. Singleton, Rina Kansal, Bertram Schnitzer   +5 more
openalex   +1 more source

Combined Immediate‐Release and Extended‐Release Formulation of Sodium Valproate Provides Stable Plasma Levels for Inhibition of Histone Deacetylation

Clinical Pharmacology in Drug Development, EarlyView.
Abstract A modified controlled‐release sodium valproate formulation (VAL001, test) was compared with an approved enteric‐coated tablet formulation (Absenor, reference). Pharmacokinetics and safety/tolerability were evaluated in healthy subjects to bridge with positive efficacy results from an early‐phase patient trial of valproate in combination with ...
Nikhil Ahuja, Susanna Kääriäinen, Zsófia Lovró, Mia Lundblad, Kristina Drott, Elsa Lilienberg, Marica T. Engström, Karla Saukkonen, Mika Scheinin   +8 more
wiley   +1 more source

Correlation of serum metabolites and clinical features in patients with peripheral T-cell lymphoma

陆军军医大学学报
Objective To explore the changes in serum energy metabolites in patients with peripheral T-cell lymphoma, and investigate serum biomarkers for monitoring peripheral T-cell lymphoma from the perspective of energy metabolism.
DUAN Yishuo, RAO Jun, XIA Jing
doaj   +1 more source

Differential Expression of T-bet, a T-box Transcription Factor Required for Th1 T-Cell Development, in Peripheral T-Cell Lymphomas [PDF]

, 2003
David M. Dorfman, Peter van den Elzen, Andrew P. Weng, Aliakbar Shahsafaei, Laurie H. Glimcher   +4 more
openalex   +1 more source

Implementing Pre‐Emptive Pharmacogenetics: Impact of Early Pharmacogenetic Screening in a Pediatric Oncology Cohort of 1,151 Subjects

Clinical Pharmacology &Therapeutics, EarlyView.
In pediatric oncology, pharmacogenetic guidelines are underutilized and the potential impact of pre‐emptive pharmacogenetic screening remains largely unexplored despite this field's need for individualized approaches. While comprehensive pharmacogenetic guidelines are not yet available for all anticancer drugs, evidence‐based recommendations exist for ...
Emma C. Bernsen, Eugène T.P. Verwiel, Maaike van der Lee, Jesse J. Swen, Marcel Santoso, Leiah J. Brigitha, Rick Admiraal, Bastiaan B.J. Tops, Alwin D.R. Huitema, Patrick Kemmeren, Jayne Y. Hehir‐Kwa, Lidwien M. Hanff, Meta H.M. Diekstra   +12 more
wiley   +1 more source