Advanced Engineering Materials, EarlyView.This study demonstrates an efficient recycling route for out‐of‐spec AlSi10Mg atomized powders through compaction and arc remelting followed by suction casting. By correlating compaction load, cooling rate, and resulting microstructure, we show that intermediate pressures (50–80 kN) and rapid cooling refine dendrites, reduce porosity, and enhance ...
Mila Christy de Oliveira +4 more
wiley +1 more source
CLL stereotyped B-cell receptor immunoglobulin sequences are recurrent in the B-cell repertoire of healthy individuals: Apparent lack of central and early peripheral tolerance censoring. [PDF]
Front Oncol, 2023 Vergani S +12 more
europepmc +1 more source
Difference in target antigens between central tolerance and peripheral tolerance deficiencies
Japanese Journal of Clinical Immunology, 2015 Failure of the immunotolerance mechanisms causes multiple organ-specific autoimmune disorders. Mutations of autoimmune regulator (AIRE) gene result in central immunotolerance deficiency named autoimmune polyendocrinopathy, candidiasis, ectodermal dystrophy (APECED).
Natsuko, Chida, Ichiro, Kobayashi
openaire +3 more sources
Mesenchymal stem cells and their use as cell replacement therapy and disease modelling tool. [PDF]
, 2008 Mesenchymal stem cells (MSCs) from adult somatic tissues may differentiate in vitro and in vivo into multiple mesodermal tissues including bone, cartilage, adipose tissue, tendon, ligament or even muscle. MSCs preferentially home to damaged tissues where
García-Castro, J +5 more
core
Advanced Engineering Materials, EarlyView.This study investigates innovative thermoreversible hydrogels derived from S53P4 bioactive glass extracts to aid in the healing of infected diabetic foot wounds. These injectable gels, which gel at body temperature, release beneficial ions and remain stable over time.
Marian G. Vargas Guerrero +9 more
wiley +1 more source
Small spleen peptides prevent development of psoriatic arthritis via restoration of peripheral tolerance. [PDF]
Mol Ther, 2022 Wixler V +8 more
europepmc +1 more source
Controlling 3D Contractility via Engineered Fibrous Hydrogel Composites
Advanced Functional Materials, EarlyView.A tunable composite contractile assembly (CCA) is developed that can permit or resist contraction without changing cell‐adhesion and density, unlike collagen whose inherent coupling of these ECM cues limits its use as a platform in contractility studies.
Karen L. Xu +7 more
wiley +1 more source
Peripheral tolerance by Treg via constraining OX40 signal in autoreactive T cells against desmoglein 3, a target antigen in pemphigus. [PDF]
Proc Natl Acad Sci U S A, 2021 Iriki H +15 more
europepmc +1 more source
Cardiac‐Derived ECM Microspheres for Enhanced hiPSC‐CMs Maturation
Advanced Functional Materials, EarlyView.Cardiac extracellular matrix microspheres derived from decellularized porcine heart provide a biomimetic 3D microenvironment for human induced pluripotent stem cell–derived cardiomyocytes (hiPSC‐CMs). This platform supports short‐ and long‐term culture, enhances structural organization, and promotes electrophysiological and functional maturation of ...
Jiazhu Xu +9 more
wiley +1 more source
Gut: Key Element on Immune System Regulation
Brazilian Archives of Biology and TechnologyThe gut is the main organ that mediates the contact between antigens with our organism, controlling the immune response against environmental factors, such as microbiota and food.
Murilo Delgobo +5 more
doaj +1 more source