Results 41 to 50 of about 507,873 (296)

NKG2D: A Master Regulator of Immune Cell Responsiveness

Frontiers in Immunology, 2018
NKG2D is an activating receptor that is mostly expressed on cells of the cytotoxic arm of the immune system. Ligands of NKG2D are normally of low abundance, but can be induced in virtually any cell in response to stressors, such as infection and ...
Felix M. Wensveen, Vedrana Jelenčić, Bojan Polić   +2 more
doaj   +1 more source

Sirolimus as Rescue Therapy for Refractory/Relapsed Immune Thrombocytopenia: Results of a Single-Center, Prospective, Single-Arm Study

Frontiers in Medicine, 2020
Immune thrombocytopenia (ITP) is an autoimmune disease which arises due to self-destruction of circulating platelets. Failure to respond or maintain a response to first-line treatment can lead to refractory/relapsed (R/R) ITP.
Yimei Feng, Yimei Feng, Yunshuo Xiao, Yunshuo Xiao, Hongju Yan, Hongju Yan, Ping Wang, Ping Wang, Wen Zhu, Wen Zhu, Kaniel Cassady, Zhongmin Zou, Kaifa Wang, Ting Chen, Ting Chen, Yao Quan, Yao Quan, Zheng Wang, Zheng Wang, Shijie Yang, Shijie Yang, Rui Wang, Rui Wang, Xiaoping Li, Xiaoping Li, Lei Gao, Lei Gao, Cheng Zhang, Cheng Zhang, Yao Liu, Yao Liu, Peiyan Kong, Peiyan Kong, Li Gao, Li Gao, Xi Zhang, Xi Zhang   +36 more
doaj   +1 more source

Peripheral B lymphocyte tolerance

The Keio Journal of Medicine, 2004
This lecture discusses two interrelated topics, B cell tolerance in the peripheral immune system and BAFF. Using the 3-83 antibody transgenic mouse bred to mice carrying cognate antigen in the liver, we previously found that clonal elimination drastically reduced the precursor frequency of autoreactive cells.
Amanda, Gavin, Djemel, Aït-Azzouzene, Annica, Mårtensson, Bao, Duong, Laurent, Verkoczy, José Luis, Vela, José Luis, Skog, Patrick, Skog, David, Nemazee   +8 more
openaire   +3 more sources

Peripheral Tolerance of CD8 T Lymphocytes [PDF]

Immunity, 2005
Whereas high-avidity recognition of peptide-MHC complexes by developing T cells in the thymus results in deletion and promotes self-tolerance, such recognition by mature T cells in the periphery results in activation and clonal expansion. This dichotomy represents the basis of a dilemma that has stumped immunologists for many years, how are self ...
Redmond, William L., Sherman, Linda A.
openaire   +2 more sources

MOLECULAR AND CELLULAR MECHANISMS MEDIATED BY DENDRITIC CELLS INVOLVED IN THE INDUCTION OF TOLERANCE

Медицинская иммунология, 2017
Autoimmune diseases  and  complications  after  transplantation  operations are  major   public health  problem, as they often  lead to deterioration in the quality  of life, reduce  work capacity  and  disability in the  population.
S. V. Sennikov, E. V. Kulikova, N. Yu. Knauer, Yu. N. Khantakova   +3 more
doaj   +1 more source

Exploring the Origin and Antigenic Specificity of Maternal Regulatory T Cells in Pregnancy

Frontiers in Immunology, 2020
Successful pregnancy outcome is partially determined by the suppression of reactive effector T cells by maternal regulatory T cells (TRegs) at the maternal-fetal interface.
Soo Hyun Ahn, Sean L. Nguyen, Sean L. Nguyen, Margaret G. Petroff, Margaret G. Petroff, Margaret G. Petroff   +5 more
doaj   +1 more source

Microchimerism, dendritic cell progenitors and transplantation tolerance [PDF]

, 1995
The recent discovery of multilineage donor leukocyte microchimerism in allograft recipients up to three decades after organ transplantation implies the migration and survival of donor stem cells within the host.
Demetris, AJ, Lu, L, Murase, N, Rao, AS, Starzl, TE, Thomson, AW   +5 more
core   +1 more source

Altered Frequency and Phenotype of HLA-G-Expressing DC-10 in Type 1 Diabetes Patients at Onset and in Subjects at Risk to Develop the Disease

Frontiers in Immunology, 2021
Type 1 diabetes (T1D) is a chronic autoimmune disease resulting in progressive destruction of β-cells. Several factors affecting lymphocyte and antigen-presenting cells, including dendritic cells (DCs), contribute to defective maintenance of tolerance in
Giada Amodio, Alessandra Mandelli, Rosalia Curto, Paola M. V. Rancoita, Angela Stabilini, Riccardo Bonfanti, Riccardo Bonfanti, Maurizio de Pellegrin, Emanuele Bosi, Emanuele Bosi, Emanuele Bosi, Clelia Di Serio, Manuela Battaglia, Silvia Gregori   +13 more
doaj   +1 more source

Hypothalamic Vitamin D Improves Glucose Homeostasis and Reduces Weight [PDF]

, 2016
Despite clear associations between vitamin D deficiency and obesity and/or type 2 diabetes, a causal relationship is not established. Vitamin D receptors (VDRs) are found within multiple tissues, including the brain.
Arble, Deanna M., Chambers, Adam P., Gardner, David, Gutierrez-Aguilar, Ruth, He, Yanlin, Moore, David D., Sandoval, Darleen A., Seeley, Randy J., Sisley, Stephanie R., Xu, Yong   +9 more
core   +4 more sources

Exploring the role of mononuclear phagocytes in the epididymis

Asian Journal of Andrology, 2015
The onslaught of foreign antigens carried by spermatozoa into the epididymis, an organ that has not demonstrated immune privilege, a decade or more after the establishment of central immune tolerance presents a unique biological challenge.
Nicolas Da Silva, Tegan B Smith
doaj   +1 more source