Results 11 to 20 of about 71,423 (312)

Role of macrophages in peritoneal dialysis-associated peritoneal fibrosis. [PDF]

Ren Fail
Peritoneal dialysis (PD) can be used as renal replacement therapy when chronic kidney disease (CKD) progresses to end-stage renal disease. However, peritoneal fibrosis (PF) is a major cause of PD failure. Studies have demonstrated that PD fluid contains a significantly larger numbers of macrophages compared with the healthy individuals.
Chu C, Huang Y, Cao L, Ji S, Zhu B, Shen Q.   +5 more
europepmc   +4 more sources

Delayed Administration of Nintedanib Ameliorates Fibrosis Progression in CG-Induced Peritoneal Fibrosis Mouse Model [PDF]

Kidney Diseases, 2022
Background: A multiple-target tyrosine kinase inhibitor, nintedanib, which is approved for treatment of interstitial pulmonary disease, has been demonstrated to have anti-fibrotic activity outside of the lungs.
Binbin Cui, Chao Yu, Shenglei Zhang, Xiying Hou, Yi Wang, Jun Wang, Shougang Zhuang, Feng Liu   +7 more
doaj   +2 more sources

A review of research progress on mechanisms of peritoneal fibrosis related to peritoneal dialysis [PDF]

Frontiers in Physiology, 2023
Peritoneal dialysis (PD) is an effective alternative treatment for patients with end-stage renal disease (ESRD) and is increasingly being adopted and promoted worldwide. However, as the duration of peritoneal dialysis extends, it can expose problems with
Jin’e Li, Jin’e Li, Yinghong Liu, Jianping Liu   +3 more
doaj   +2 more sources

Mechanisms of Peritoneal Fibrosis: Focus on Immune Cells–Peritoneal Stroma Interactions [PDF]

Frontiers in Immunology, 2021
Peritoneal fibrosis is characterized by abnormal production of extracellular matrix proteins leading to progressive thickening of the submesothelial compact zone of the peritoneal membrane.
Michela Terri, Michela Terri, Flavia Trionfetti, Flavia Trionfetti, Claudia Montaldo, Marco Cordani, Marco Tripodi, Marco Tripodi, Marco Tripodi, Manuel Lopez-Cabrera, Raffaele Strippoli, Raffaele Strippoli   +11 more
doaj   +5 more sources

Mechanisms underlying the involvement of peritoneal macrophages in the pathogenesis and novel therapeutic strategies for dialysis-induced peritoneal fibrosis [PDF]

Frontiers in Immunology
Long-term exposure of the peritoneum to peritoneal dialysate results in pathophysiological changes in the anatomical organization of the peritoneum and progressive development of peritoneal fibrosis.
Yangwei Wang, Yixian Zhang, Mingqi Ma, Xiaohua Zhuang, Yue Lu, Lining Miao, Xuehong Lu, Yingchun Cui, Wenpeng Cui   +8 more
doaj   +2 more sources

Peritoneal fibrosis. [PDF]

BMJ, 1977
R. David Rosin
openalex   +4 more sources

Clinical and preclinical studies of mesenchymal stem cells to alleviate peritoneal fibrosis [PDF]

Stem Cell Research & Therapy
Peritoneal dialysis is an important part of end-stage kidney disease replacement therapy. However, prolonged peritoneal dialysis can result in peritoneal fibrosis and ultrafiltration failure, forcing patients to withdraw from peritoneal dialysis ...
Lingqian Zheng, Wenmin Chen, Kaijin Yao, Yina Xie, Chunling Liao, Tianbiao Zhou   +5 more
doaj   +2 more sources

Tamoxifen ameliorates peritoneal membrane damage by blocking mesothelial to mesenchymal transition in peritoneal dialysis. [PDF]

PLoS ONE, 2013
Mesothelial-to-mesenchymal transition (MMT) is an auto-regulated physiological process of tissue repair that in uncontrolled conditions such as peritoneal dialysis (PD) can lead to peritoneal fibrosis.
Jesús Loureiro, Pilar Sandoval, Gloria del Peso, Guadalupe Gónzalez-Mateo, Vanessa Fernández-Millara, Beatríz Santamaria, Maria Auxiliadora Bajo, José Antonio Sánchez-Tomero, Gonzalo Guerra-Azcona, Rafael Selgas, Manuel López-Cabrera, Abelardo I Aguilera   +11 more
doaj   +6 more sources

Galectin-1 promotes gastric cancer peritoneal metastasis through peritoneal fibrosis. [PDF]

BMC Cancer, 2023
Abstract Background Peritoneal metastasis is one of the main causes of death in patients with gastric cancer (GC). Galectin-1 regulates various undesirable biological behaviors in GC and may be key in GC peritoneal metastasis. Methods
Shen X, Liu H, Zhou H, Cheng Z, Liu G, Huang C, Dou R, Liu F, You X.   +8 more
europepmc   +4 more sources

Pathophysiological Mechanisms of Peritoneal Fibrosis and Peritoneal Membrane Dysfunction in Peritoneal Dialysis. [PDF]

Int J Mol Sci
The characteristic feature of chronic peritoneal damage in peritoneal dialysis (PD) is a decline in ultrafiltration capacity associated with pathological fibrosis and angiogenesis. The pathogenesis of peritoneal fibrosis is attributed to bioincompatible factors of PD fluid and peritonitis. Uremia is associated with peritoneal membrane inflammation that
Ito Y, Sun T, Tawada M, Kinashi H, Yamaguchi M, Katsuno T, Kim H, Mizuno M, Ishimoto T.   +8 more
europepmc   +3 more sources