Results 51 to 60 of about 288,150 (296)

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Comparative analysis of the mutational landscape and evolutionary patterns of pancreatic ductal adenocarcinoma metastases in the liver or peritoneum

Heliyon
Background: Pancreatic ductal adenocarcinoma (PDAC) often presents with liver or peritoneal metastases at diagnosis. Despite similar treatment approaches, patient outcomes vary between these metastatic sites.
Guoliang Yao, Yanfeng Zhu, Chunhui Liu, Yanwen Man, Kefeng Liu, Qin Zhang, Yuan Tan, Qianqian Duan, Dongsheng Chen, Zunguo Du, Yonggang Fan   +10 more
doaj   +1 more source

[Systemic treatment of peritoneal metastases]

, 2007
Peritoneal metastases are common in metastatic disease of many tumour types and thus are determinant for prognosis and development of tumour-related symptoms that jeopardise quality of life.
Arnold, D;Lordick, F
core   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Progression-free survival for patients with colorectal peritoneal metastases treated by cytoreductive surgery and systemic chemotherapy according to presence of liver or lung metastases.

, 2015
Progression-free survival for patients with colorectal peritoneal metastases treated by cytoreductive surgery and systemic chemotherapy according to presence of liver or lung metastases.
Jérémy Vara (715328), Camille Mazière (715327), Yves Bécouarn (715331), Véronique Brouste (3910411), Grégoire Désolneux (5662768), Marianne Fonck (715329), Dominique Béchade (715330), Serge Evrard (671453)   +7 more
core   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Genetic Evidence for Early Peritoneal Spreading in Pelvic High-Grade Serous Cancer

Frontiers in Oncology, 2018
BackgroundMost pelvic high-grade serous (HGS) carcinomas have been proposed to arise from tubal primaries that progress rapidly to advanced disease. However, the temporal sequence of ovarian and peritoneal metastases is not well characterized.MethodsTo ...
Jeremy Chien, Lisa Neums, Alexis F. L. A. Powell, Michelle Torres, Kimberly R. Kalli, Francesco Multinu, Viji Shridhar, Andrea Mariani   +7 more
doaj   +1 more source

Overall survival for patients with colorectal peritoneal metastases treated by cytoreductive surgery and systemic chemotherapy according to presence of liver or lung metastases.

, 2015
Overall survival for patients with colorectal peritoneal metastases treated by cytoreductive surgery and systemic chemotherapy according to presence of liver or lung metastases.
Jérémy Vara (715328), Camille Mazière (715327), Yves Bécouarn (715331), Véronique Brouste (3910411), Grégoire Désolneux (5662768), Marianne Fonck (715329), Dominique Béchade (715330), Serge Evrard (671453)   +7 more
core   +1 more source

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source

Clinical significance of preoperative Glasgow prognostic score in patients with colorectal cancer and synchronous peritoneal metastases

Annals of Gastroenterological Surgery
Background Chemotherapy is the typical choice for treating colorectal cancer with synchronous peritoneal metastases. Nonetheless, surgical resection may be chosen if the metastases are resectable.
Kosuke Fujimoto, Fumikazu Koyama, Hirotoshi Kobayashi, Kenjiro Kotake, Masayasu Kawasaki, Yukihide Kanemitsu, Yusuke Kinugasa, Hideki Ueno, Kotaro Maeda, Takeshi Suto, Michio Itabashi, Kimihiko Funahashi, Heita Ozawa, Shingo Noura, Hideyuki Ishida, Masayuki Ohue, Tomomichi Kiyomatsu, Soichiro Ishihara, Keiji Koda, Hideo Baba, Kenji Kawada, Yojiro Hashiguchi, Takanori Goi, Yuji Toiyama, Naohiro Tomita, Eiji Sunami, Fumihiko Fujita, Jun Watanabe, Kenichi Hakamada, Goro Nakayama, Kenichi Sugihara, Yoichi Ajioka   +31 more
doaj   +1 more source