Results 51 to 60 of about 165,251 (351)

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

The molecular biology of peritoneal metastatic disease

EMBO Molecular Medicine, 2023
Peritoneal metastases are a common form of tumor cell dissemination in gastrointestinal malignancies. Peritoneal metastatic disease (PMD) is associated with severe morbidity and resistance to currently employed therapies.
Sanne Bootsma, Maarten F Bijlsma, Louis Vermeulen   +2 more
doaj   +1 more source

Expression of factor V by resident macrophages boosts host defense in the peritoneal cavity [PDF]

, 2019
Macrophages resident in different organs express distinct genes, but understanding how this diversity fits into tissue-specific features is limited. Here, we show that selective expression of coagulation factor V (FV) by resident peritoneal macrophages ...
Broze, George J, Cleuren, Audrey C, Czepielewski, Rafael S, Edelson, Brian T, Erlich, Emma C, Esaulova, Ekaterina, Grover, Steven P, Jarjour, Nicholas N, Mackman, Nigel, Randolph, Gwendalyn J, Saunders, Brian T, Zhang, Nan, Zinselmeyer, Bernd H   +12 more
core   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Prevention of Peritoneal Adhesions by Non-Thermal Dielectric Barrier Discharge Plasma Treatment on Mouse Model: A Proof of Concept Study

Journal of Investigative Surgery, 2020
Purposes: Formation of peritoneal adhesions is a common consequence of abdominopelvic surgeries and remarkably increases the mortality and morbidity. Moreover, peritoneal adhesions linked to chronic abdominopelvic pain and infertility in women.
Uğur Gökçelli, Utku Kürşat Ercan, Enver İlhan, Asuman Argon, Elif Çukur, Orhan Üreyen   +5 more
doaj   +1 more source

Fecal microbiota transplant rescues mice from human pathogen mediated sepsis by restoring systemic immunity. [PDF]

, 2020
Death due to sepsis remains a persistent threat to critically ill patients confined to the intensive care unit and is characterized by colonization with multi-drug-resistant healthcare-associated pathogens.
Alverdy, John C, Antonopoulos, Dionysios A, Barreiro, Luis B, Bouziat, Romain, Christley, Scott, DeFazio, Jennifer R, Ernest, Jordan D, Fleming, Irma D, Gilbert, Jack A, Harris, Katharine G, Hyoju, Sanjiv K, Jabri, Bana, Keskey, Robert, Khodarev, Nikolai N, Kim, Sangman M, Krezalek, Monika A, Malik, Ankit, Ranoa, Diana R, Sangani, Kishan, Sangwan, Naseer, Shakhsheer, Baddr A, Weichselbaum, Ralph R, Wiegerinck, Mara, Zaborin, Alexander, Zaborina, Olga   +24 more
core  

Smart, Bio‐Inspired Polymers and Bio‐Based Molecules Modified by Zwitterionic Motifs to Design Next‐Generation Materials for Medical Applications

Advanced Functional Materials, EarlyView.
Bio‐based and (semi‐)synthetic zwitterion‐modified novel materials and fully synthetic next‐generation alternatives show the importance of material design for different biomedical applications. The zwitterionic character affects the physiochemical behavior of the material and deepens the understanding of chemical interaction mechanisms within the ...
Theresa M. Lutz, Jonas De Breuck, Sahar Salehi, Meike N. Leiske   +3 more
wiley   +1 more source

Embryological, anatomical and clinical considerations on pleuroperitoneal communication

Pleura and Peritoneum, 2023
The pleural and peritoneal cavity share many related features due to their common celomic origin. Normally these two spaces are completely separated with the development of the diaphragm.
Chatzigrigoriadis Christodoulos, Goulioumis Anastasios, Sperdouli Despoina, Gyftopoulos Kostis   +3 more
doaj   +1 more source

3D‐Printed Gastrointestinal Stents: In Vivo Evaluation in a Swine Small Bowel Perforation Model

Advanced Healthcare Materials, EarlyView.
Gastrointestinal fistulae and perforations can lead to severe complications including sepsis and patient death. In this work, the efficacy of 3D‐printed gastrointestinal stents composed of poly‐lactic‐acid (PLA) was evaluated in an in vivo swine model.
Gweniviere Capron, Parinaz Fathi, Tor Wolf Jensen, Derek J. Milner, André J. van der Vlies, Regan L. Moody, Elizabeth A. Bangert, Blair Rowitz, Dipanjan Pan, Matthew B. Wheeler   +9 more
wiley   +1 more source

Cutaneous melanoma in older patients

BMC Geriatrics
Background In industrialized countries, the aging population is steadily rising. The incidence of cutaneous malignant melanoma (CMM) is highest in old people.
Alessandra Buja, Massimo Rugge, Chiara Trevisiol, Anna Zanovello, Alessandra Rosalba Brazzale, Manuel Zorzi, Antonella Vecchiato, Paolo Del Fiore, Saveria Tropea, Marco Rastrelli, Carlo Riccardo Rossi, Simone Mocellin   +11 more
doaj   +1 more source