Results 71 to 80 of about 1,195,562 (344)

A bioinformatics screen identifies TCF19 as an aggressiveness‐sustaining gene in prostate cancer

Molecular Oncology, EarlyView.
Gene expression meta‐analysis in multiple prostate cancer patient cohorts identifies Transcription factor 19 (TCF19) as an aggressiveness‐sustaining gene with prognostic potential. TCF19 is a gene repressed by androgen signaling that sustains core cancer‐related processes such as vascular permeability or tumor growth and metastasis.
Amaia Ercilla, Jana R. Crespo, Saioa Garcia‐Longarte, Marta Fidalgo, Sara del Palacio, Natalia Martin‐Martin, Onintza Carlevaris, Ianire Astobiza, Sonia Fernández‐Ruiz, Marc Guiu, Laura Bárcena, Isabel Mendizabal, Ana M. Aransay, Mariona Graupera, Roger R. Gomis, Arkaitz Carracedo   +15 more
wiley   +1 more source

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source

Matrix: a complex amalgam of structures and functions in tumor microenvironment

FEBS Open Bio, EarlyView.
The matrix is a dynamic, intricate three‐dimensional mesh of biomolecules with both structural and functional properties. This review deals with the complexity of this ‘molecular amalgam’ in the tumor microenvironment and highlights its importance in the maintenance and evolution of tumors by describing certain matrix biomolecules, such as ...
Spyros S. Skandalis, Evgenia Tsoukala, Theodora D. Sarantopoulou, Maria‐Elpida Christopoulou   +3 more
wiley   +1 more source

Paleo-sedimentary environmental restoration and its significance of Chang 7 Member of Triassic Yanchang Formation in Ordos Basin, NW China

Petroleum Exploration and Development, 2018
Paleo-sedimentary environment of Chang 7 Member of Upper Triassic Yanchang Formation in Ordos Basin, including the paleoclimate, paleo-salinity and paleo-redox conditions were restored through geochemical elements analysis of 289 samples collected from ...
Jinhua FU, Shixiang LI, Liming XU, Xiaobing NIU   +3 more
doaj   +1 more source

Intestinal Permeability in Inflammatory Bowel Disease: Pathogenesis, Clinical Evaluation, and Therapy of Leaky Gut

Mediators of Inflammation, 2015
The pathogenesis of inflammatory bowel disease (IBD) is multifactorial with data suggesting the role of a disturbed interaction between the gut and the intestinal microbiota.
A. Michielan, R. D'Incà
semanticscholar   +1 more source

Osmotic pressure‐induced calcium response states

FEBS Open Bio, EarlyView.
Acute hypotonic stress triggers distinct calcium response patterns in HEK293T cells. These signals originate from the endoplasmic reticulum via RyR2 and propagate to neighboring cells through gap junctions. This result highlights a novel calcium‐dependent mechanism underlying the intracellular and intercellular response to osmotic pressure.
Zidan Gao, Keiji Naruse, Masatoshi Morimatsu   +2 more
wiley   +1 more source

Geological characteristics and exploration of shale oil in Chang 7 Member of Triassic Yanchang Formation, Ordos Basin, NW China

Petroleum Exploration and Development, 2020
A set of shale-dominated source rocks series were deposited during the heyday of lake basin development in the Member 7 of Triassic Yanchang Formation, Ordos Basin, and the thickness is about 110 m.
Jinhua FU, Shixiang LI, Xiaobing NIU, Xiuqin DENG, Xinping ZHOU   +4 more
doaj   +1 more source

Cis‐unsaturated sphingolipids support growth of sphingoid base‐deficient yeast but impair plasma membrane integrity

FEBS Open Bio, EarlyView.
Sphingoid base structures, the sphingolipid backbones, vary among species. We established yeast cells in which the native sphingoid base was replaced with plant‐type bases containing cis or trans double bonds. This is, to our knowledge, the first eukaryotic model mostly composed of sphingolipids containing cis‐unsaturated sphingoid base, providing a ...
Takashi Higuchi, Saki Sugihara, Yohei Ishibashi, Kono Yushi, Hazuki Yamauchi, Motohiro Tani   +5 more
wiley   +1 more source

Main controlling factors and exploration enlightenment of aluminous rock series gas reservoirs in Ordos Basin, NW China

Petroleum Exploration and Development
Based on the data of outcrop, core, logging, gas testing, and experiments, the natural gas accumulation and aluminous rock mineralization integrated research was adopted to analyze the controlling factors of aluminous rock series effective reservoirs in ...
Lei ZHANG, Qian CAO, Caili ZHANG, Jianwu ZHANG, Jiayi WEI, Han LI, Xingjian WANG, Xing PAN, Ting YAN, Haiqi QUAN   +9 more
doaj   +1 more source

Reservoir formation conditions and key technologies for exploration and development in Qingcheng large oilfield

Petroleum Research, 2020
The Qingcheng oilfield, the largest shale oil field in China, was discovered in 2019 in source rock of Chang 7 Member of Mesozoic Yanchang Formation, Changqing Oilfield in Ordos Basin, with newly increased proven geological reserves of 358 million tons ...
Suotang Fu, Jinhua Fu, Xiaobing Niu, Shixiang Li, Zhiyu Wu, Xinping Zhou, Jiangyan Liu   +6 more
doaj   +1 more source