Results 61 to 70 of about 1,459,501 (364)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

A Method for Filling Blank Stripes in Electrical Imaging Based on the Fusion of Arbitrary Kernel Convolution and Generative Adversarial Networks

Applied Sciences
Electrical imaging logging images play a crucial role in petroleum exploration; however, in practical applications, blank strips frequently appear due to instrument malfunctions or data transmission failures, severely compromising geological ...
Ruhan A, Die Liu, Ge Cao, Kun Meng, Taiping Zhao, Lili Tian, Bin Zhao, Guilan Lin, Sinan Fang   +8 more
doaj   +1 more source

Optimization of horizontal well injection-production parameters for ultra-low permeable–tight oil production: A case from Changqing Oilfield, Ordos Basin, NW China

Petroleum Exploration and Development, 2015
There are two kinds of displacement mechanisms and three different seepage stages during horizontal well development process with water injection energy.
Jiyong ZHAO, Jianming FAN, Yonghong HE, Ziqing YANG, Wei GAO, Wubin GAO   +5 more
doaj   +1 more source

The food contaminant deoxynivalenol, decreases intestinal barrier permeability and reduces claudin expression [PDF]

, 2009
The gastrointestinal tract represents the first barrier against food contaminants as well as the first target for these toxicants. Deoxynivalenol (DON) is a mycotoxin that commonly contaminates cereals and causes various toxicological effects.
Nougayrède, Jean-Philippe, Oswald, Isabelle P, Moreno, Carolina, Marin, Daniela E., Loureiro-Bracarense, Ana-Paula, Ferrier, Laurent, Oswald, Isabelle P., Pinton, Philippe, Del Rio, Juan-Carlos, Kolf-Clauw, Martine, Bracarense, Ana-Paula   +10 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Evolution of the Ordovician top boundary and its relationship to reservoirs' development, Ordos Basin

Petroleum Exploration and Development, 2012
The control of structural evolution on the development of different types of Ordovician reservoirs in the Ordos Basin is discussed by studying the evolution of the Ordovician top boundary in geological times, and the mechanisms of formation and evolution
Xinquan RAN, Jinhua FU, Xinshan WEI, Junfeng REN, Liuyi SUN, Hongping BAO   +5 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Pore structure characterization of low permeability rocks [PDF]

, 2014
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro Tecnológico, Programa de Pós-Graduação em Ciência e Engenharia de Materiais, Florianópolis, 2014.Hoje as pesquisas em rochas de baixa permeabilidade (grande tendência no mundo e em breve ...
Schmitt, Mayka
core  

Assessment of Permeability in Barrier Type of Endothelium in Brain Using Tracers: Evans Blue, Sodium Fluorescein, and Horseradish Peroxidase

, 2021
Blood-brain barrier (BBB) constituted primarily by the capillary endothelial cells functions to maintain a constant environment for the brain, by preventing or slowing down the passage of a variety of blood-borne substances, such as serum proteins ...
Ahishali, Bulent, Kaya, Mehmet
core   +1 more source

Intestinal permeability – a new target for disease prevention and therapy

BMC Gastroenterology, 2014
Data are accumulating that emphasize the important role of the intestinal barrier and intestinal permeability for health and disease. However, these terms are poorly defined, their assessment is a matter of debate, and their clinical significance is not ...
S. Bischoff, G. Barbara, W. Buurman, T. Ockhuizen, J. Schulzke, M. Serino, H. Tilg, A. Watson, J. Wells   +8 more
semanticscholar   +1 more source