Results 261 to 270 of about 41,464 (303)
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Surface Barrier for Tritium Permeation
Fusion Technology, 1995To apply the surface barrier to reduce hydrogen permeation, the influence of the surface barrier on both the permeation and retention has been investigated considering physical and chemical stability of the barrier in fusion environment Since energetic hydrogen from the plasma not only impinges directly into subsurface but also removes the front ...
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QSAR model for blood-brain barrier permeation
Journal of Pharmacological and Toxicological Methods, 2017Predicting blood-brain barrier permeability for novel compounds is an important goal for neurotherapeutics-focused drug discovery. It is impossible to determine experimentally the blood-brain barrier partitioning of all possible candidates. Consequently, alternative evaluation methods based on computational models are desirable or even necessary.
Andrey A. Toropov +4 more
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Barrier permeation and improved nanomedicine delivery in tumor microenvironments
Cancer Letters, 2023Nanomedicines can effectively penetrate tumor sites compared to traditionally used drugs. However, effective drugs that reach the interior of tumors remain limited. Based on studies of the complex tumor microenvironment, we summarized the barriers restricting tumor penetration of nanomedicines in this review.
Jinxiang Liu +7 more
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Benchmarking of QSAR Models for Blood-Brain Barrier Permeation
Journal of Chemical Information and Modeling, 2007Using the largest available database of 328 blood-brain distribution (logBB) values, a quantitative benchmark was proposed to allow for a consistent comparison of the predictive accuracy of current and future logBB/quantitative structure-activity relationship (-QSAR) models.
Dmitry A. Konovalov +3 more
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In Silico Prediction Models for Blood-Brain Barrier Permeation
Current Medicinal Chemistry, 2004The ability to permeate across the blood brain barrier (BBB) is essential for drugs acting on the central nervous system (CNS). Thus, for speeding up the drug discovery process in the CNS-area, it is of great importance to develop systems that allow rapid and inexpensive screening of the BBB-permeability properties of novel lead compounds or at least ...
Noe, Christian, Ecker, Gerhard
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Tritium permeation barriers for fusion technology
Fusion Engineering and Design, 1995Abstract A review of the effectiveness as permeation barriers of several coatings deposited on materials of interest for fusion technology is presented. The coating materials studied were Al 2 O 3 , TiC and a bilayer of TiC/TiN deposited by pack cementation, chemical vapour deposition (CVD) and vacuum plasma spraying (VPS). Also, the effectiveness of
A Perujo, K.S Forcey
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The formation of tritium permeation barriers by CVD
Journal of Nuclear Materials, 1993Abstract The effectiveness as permeation barriers of the following CVD coatings have been investigated: TiC (1 to 2 μm in thickness); a bi-layer of TiN on TiC (3 μm total thickness) and CVD A12O3 on a TiN/TiC bi-layer. The substrate materials were TZM (a Mo alloy) and 316L stainless steel in the form of discs of diameter 48 mm and thickness 0.1 or 1 ...
K.S. Forcey +3 more
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Permeation and Permeation Barrier
2016Because of their small sizes in molecular and atomic forms, hydrogen isotopes easily dissolve in a solid material and permeate through it. The permeation through a container material is a critical issue against safe confinement of tritium. On the other hand, it is common to employ a permeation technique for the separation of hydrogen isotopes from ...
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Diffusion of water into permeation barrier layers
Journal of Vacuum Science & Technology A: Vacuum, Surfaces, and Films, 2015Organic light emitting diodes (OLEDs) are attractive candidates for flexible display and lighting panels due to their high contrast ratio. However, the materials in an OLED are oxidized by very small quantities of moisture. Therefore, flexible OLEDs require flexible, thin-film, encapsulation.
Visweswaran, Bhadri +6 more
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In silico prediction of blood–brain barrier permeation
Drug Discovery Today, 2003This review examines the progress that is being made towards the in silico prediction of brain permeation. Following a brief introduction to the blood-brain barrier, the datasets currently available for in silico modeling are discussed. Recent developments in in silico models of brain permeation are summarized in the context of the current state of the
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