Results 271 to 280 of about 41,464 (303)
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Drug Development and Industrial Pharmacy, 2000
To evaluate the pathways and barrier components in the stratum corneum (SC) for the permeation of ketotifen, the effect of delipidization on the permeation and partition was examined under several donor pHs. Assuming that ionized ketotifen (KTH+) and un-ionized ketotifen (KT) contribute independently in both permeation and partition, the intrinsic ...
K, Inoue +6 more
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To evaluate the pathways and barrier components in the stratum corneum (SC) for the permeation of ketotifen, the effect of delipidization on the permeation and partition was examined under several donor pHs. Assuming that ionized ketotifen (KTH+) and un-ionized ketotifen (KT) contribute independently in both permeation and partition, the intrinsic ...
K, Inoue +6 more
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HYDROGEN BARRIER COATINGS AND THEIR PERMEATION RESISTANCE
Problems of Atomic Science and TechnologyThis review discusses the state of the art in hydrogen permeation for a variety of coatings. Hydrogen ingress into structural materials can be detrimental due to corrosion and embrittlement. To enable safe operation in applications requiring protection from hydrogen isotopes, recent advances in material design and performance characterization of ...
G.D. Tolstolutska +4 more
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A recursive-partitioning model for blood–brain barrier permeation
Journal of Computer-Aided Molecular Design, 2005A series of bagged recursive partitioning models for log(BB) is presented. Using a LGO-CV, three sets of physical property descriptors are evaluated and found to have Q2 values of 0.51 (CPSA), 0.53 (Ro5x) and 0.53 (MOE). Extrapolating these models to Pfizer chemical space is difficult due to P-glycoprotein (P-gp) mediated efflux.
Scot Mente, Franco Lombardo
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The factors that influence permeation across the blood–brain barrier
European Journal of Medicinal Chemistry, 2004Using data on perfusion from saline at pH 7.4 taken from the literature, it is shown that logarithms of PS-products, log PS, can satisfactorily be correlated with the five Abraham descriptors for 30 neutral compounds. The equation has R(2) = 0.870 and S.D.
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The permeation of drugs across the placental barrier
Naunyn-Schmiedebergs Archiv f�r Pharmakologie und Experimentelle Pathologie, 1968H, Kurz, H, Fasching
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Drug Permeation through Biological Barriers
2001In multicellular organisms, thin lipid membranes serve as semipermeable barriers between aqueous compartments. The plasma membrane of the cell separates the cytoplasm from the extracellular space; endothelial cell membranes separate the blood within the vascular space from the rest of the tissue.
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Graphene synthesized by chemical vapor deposition as a hydrogen isotope permeation barrier
Carbon, 2021Katherine T Young +2 more
exaly
Improvement of hydrogen permeation barrier performance by iron sulphide surface films
International Journal of Minerals, Metallurgy and Materials, 2023Pengpeng Bai +2 more
exaly
A study of the permeation barrier of nanoporous Graphene
Materials Today: Proceedings, 2023Tribikram Gupta +2 more
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