Results 71 to 80 of about 41,464 (303)

Skin Barriers in Dermal Drug Delivery: Which Barriers Have to Be Overcome and How Can We Measure Them?

open access: yesPharmaceutics, 2020
Although, drugs are required in the various skin compartments such as viable epidermis, dermis, or hair follicles, to efficiently treat skin diseases, drug delivery into and across the skin is still challenging.
Christian Gorzelanny   +4 more
doaj   +1 more source

Study on the Influence of Introducing Al Transition Layer on Deuterium Resistance of Al2O3 Coating

open access: yesInternational Journal of Photoenergy, 2021
The Al/Al2O3 composite deuterium barrier was deposited on the polished side of 316 L stainless steel by the method of radio-frequency magnetron sputtering.
Weijing Wang   +9 more
doaj   +1 more source

Artery‐on‐Chip Demonstrates Mechanical and Functional Features of Healthy and Diseased Living Smooth Muscle Tissue

open access: yesAdvanced Functional Materials, EarlyView.
This article details the development of an artery‐on‐chip platform for in vitro arterial disease modeling and therapeutic discovery. It describes the fabrication of a fibrin biomaterial scaffold seeded with iPSC‐derived smooth muscle and endothelial cells, mimicking native artery properties. Two genetic disease models showcase the platform's ability to
Danielle Yarbrough   +10 more
wiley   +1 more source

Supramolecular and Macromolecular Matrix Nanocarriers for Drug Delivery in Inflammation-Associated Skin Diseases

open access: yesPharmaceutics, 2020
Skin is our biggest organ. It interfaces our body with its environment. It is an efficient barrier to control the loss of water, the regulation of temperature, and infections by skin-resident and environmental pathogens.
Ranime Jebbawi   +4 more
doaj   +1 more source

Pull‐and‐Push Nanotherapeutic Hydrogels: Scavenging Inflammatory Triggers While Driving Tissue Regeneration in Burn Wounds

open access: yesAdvanced Functional Materials, EarlyView.
A nanounit‐assembled hydrogel employing a “pull‐and‐push” strategy simultaneously scavenges pro‐inflammatory cell‐free DNA (cfDNA) and delivers regenerative therapeutics in response to burn‐induced hyperthermia. By repolarizing macrophages and promoting angiogenesis, this multifunctional platform accelerates burn wound healing, offering a blueprint for
Han‐Sem Kim   +9 more
wiley   +1 more source

The Phenion (R) Full-Thickness Skin Model for Percutaneous Absorption Testing [PDF]

open access: yes, 2010
In recent years many efforts have been made to replace dermal toxicity testing of chemicals in the animal by in vitro assays. As a member of a German research consortium, we have previously contributed to the validation of an in vitro test protocol for ...
Korting, Hans Christian   +4 more
core   +1 more source

Permeation of Growth Hormone across the Blood-Brain Barrier [PDF]

open access: yesEndocrinology, 2005
Exogenous GH can affect central nervous system function when given peripherally to animals and as a supplemental therapy to humans. This study tested whether GH crosses the blood-brain barrier (BBB) by a specific transport system and found that both mice and rats have small but significant uptake of GH into the brain without a species difference ...
Weihong, Pan   +5 more
openaire   +2 more sources

Myrcene‐Based Tailored Co‐Polymers as Active Pharmaceutical Excipients: Bio‐Based Solutions for Mucoadhesive Excipients

open access: yesAdvanced Functional Materials, EarlyView.
Mucoadhesive amphiphilic block and statistical copolymers were synthesized via Reversible Addition–Fragmentation Chain Transfer polymerization from bio‐sourced myrcene and polyethylene glycol methacrylate. The resulting polymers exhibit narrow molar‐mass distributions, high regioselectivity, well‐defined microstructures, and tend to self‐assemble into ...
David Gintsburg   +9 more
wiley   +1 more source

Effects of helium implantation on the deuterium permeation behavior in oxidized Fe-Cr-Al ferritic steel

open access: yesNuclear Materials and Energy
The stability of microstructure and functions under irradiation is a critical issue for tritium permeation barriers (TPBs). High-energy ion irradiation has been an ideal tool for studying the effects of irradiation on the hydrogen isotope permeation ...
Huai-Zhi Li   +4 more
doaj   +1 more source

Redirecting Nano‐Silicon Agglomeration: Dual‐Carbon Design Triggers Self‐Adaptive Nanoporous Si Sponge for Enhanced Lithium Storage

open access: yesAdvanced Functional Materials, EarlyView.
This study addresses silicon anode degradation using an engineered nSi/Gr/C dual‐carbon matrix. By restricting SEI infiltration, the architecture redirects silicon agglomeration into a beneficial structural self‐adaptive activation. During cycling, silicon nanoparticles self‐organize into a resilient nanoporous sponge. This dynamic network accommodates
Wei Zhang   +7 more
wiley   +1 more source

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