Results 211 to 220 of about 100,349 (273)

Formulation and Characterization of Captopril-Loaded Chitosan Mucoadhesive Buccal Films with Different Permeation-Enhancing Components. [PDF]

Pharmaceutics
Rayya H, Alsheikh R, Nemes D, Nagy L, Regdon G, Bácskay I, Pamlényi K, Kristó K.   +7 more
europepmc   +1 more source

Loss of CYLD on Chromosome 16q Impairs Homologous Recombination and Genomic Stability Through TIRR Degradation

Advanced Science, EarlyView.
Chromosome 16q loss drives genomic instability through disruption of the CYLD–TIRR–53BP1 axis. CYLD preserves homologous recombination by stabilizing TIRR and limiting 53BP1 accumulation at DNA double‐strand breaks. CYLD deficiency redirects repair toward error‐prone non‐homologous end joining, promotes mutational burden and homologous recombination ...
Mingming Lu, Jialu Kang, Qi Ye, Zixi Wang, Lei Li, Yuzeshi Lei, Leihong Ye, Tianjie Liu, Bin Wang, Tao Liu, Shan Xu, Ke Wang, Yong Zhang, Jian Ma, Lei Li   +14 more
wiley   +1 more source

Targeting β2‐Adrenergic Receptor Stability With Lycorine Reveals a Host‐Directed Pathway for Antiviral Defense Against Poxviruses

Advanced Science, EarlyView.
Chronic stress drives autophagy‐mediated β2‐AR degradation, impairing antiviral immunity and promoting poxvirus lethality. Lycorine directly stabilizes β2‐AR to restore host defense, suppress excessive inflammation and improve survival. ABSTRACT Psychological stress is a pervasive yet poorly understood modulator of infectious disease outcomes. Here, we
Xin Zhang, Shuqin Xu, Zixuan Zhang, Chenwen Wan, Xiaoqin Wang, Peihua Wang, Huini Yang, Tianxiao Huang, Yijia Yuan, Faiza Atique, Rui Yang, Yingli He, Zhijun Liu   +12 more
wiley   +1 more source

Revealing the Underlying Mechanisms in Performance Enhancement of Shellular Lattice Electrodes During Anion Exchange Membrane Water Electrolysis Process

Advanced Science, EarlyView.
Micro laser powder bed fusion enables architected nickel shellular lattice gas diffusion layers for anion exchange membrane water electrolysis. Among regular open cell geometries, the Gyroid lattice promotes bubble release, convective reactant replenishment and continuous electron transport, delivering low overpotentials, enhanced charge transfer and ...
Tianxiao Niu, Rui Li, Xiao Chen, Deyong Sun, Tianyu Gao, Junhao Ding, Shuo Qu, Xu Song   +7 more
wiley   +1 more source

Skin Barrier-Informed Topical and Transdermal Drug Delivery: Excipient-Driven Strategies, Vehicle Transformation, and Translational Challenges. [PDF]

Pharmaceutics
Sapkota B, Phuyal S, Bamjan AD, Cho SS, Shim JH, Park JW, Subedi L.   +6 more
europepmc   +1 more source

Defect‐Engineered BiO2‐X Nanosheets Mediate Sono‐Thermomechanical ECM Remodeling for Hepatocellular Carcinoma Immunotherapy

Advanced Science, EarlyView.
Herein, an ultrasound‐responsive BiO2‐X/siFn1 nanoplatform is developed to overcome anti‐PD‐1 resistance in hepatocellular carcinoma. Upon ultrasound irradiation, the platform downregulates fibronectin expression, while its sonothermal effect softens the dense extracellular matrix and activates antitumor immunity in the tumor microenvironment, thereby ...
Huimin Tian, Shen Zhang, Bolin Wu, Yichi Chen, Haitao Shang, Haoyan Tan, Chunyue Wang, Weichen Xu, Huixiong Xu, Haohao Yin, Wen Cheng   +10 more
wiley   +1 more source

The fourth controlled release society workshop on oral peptide administration. [PDF]

Front Drug Deliv
Brayden DJ, Buckley ST, Lewis AL.
europepmc   +1 more source

Protein Delivery Using Three-Dimensional Printing of Buccal Films: Technological Advances and Clinical Potential. [PDF]

Pharmaceutics
Appidi T, Anekalla TR, Chede S, Chakka LRJ, Maniruzzaman M.   +4 more
europepmc   +1 more source

Natural Oral Absorption of Therapeutic Peptides: Mechanisms and Physiological Determinants. [PDF]

Pharmaceutics
Ali Hussein L, Nedic A, Sitovs A, Mohylyuk V.   +3 more
europepmc   +1 more source

Impact of Menthol Concentration on Ketoprofen Permeation and Photostability in Compounded Topical Preparations in a Pentravan Base. [PDF]

ACS Omega
Adamiak-Giera U, Gackowski M, Malinowski D, Osmałek T, Michniak-Kohn B, Kurzawski M, Machoy-Mokrzyńska A, Białecka M.   +7 more
europepmc   +1 more source