Results 231 to 240 of about 100,349 (273)

Effect of Permeation Enhancers on Buccal Absorption

Arzneimittelforschung, 2011
This paper reports an investigation on matrices based on the mucoadhesive polymers hydroxypropylmethylcellulose and sodium alginate, intended for sublingual administration of 1 mg lorazepam (LZ, 7-chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one, CAS 846-49-1).
Susi, Burgalassi, Patrizia, Chetoni, Laura, Dini, Marcela, Najarro, Daniela, Monti, Paolo, Morelli, M Fabrizio, Saettone   +6 more
openaire   +2 more sources

Enhancement of transmucosal permeation of cyclosporine by benzalkonium chloride

Oral Diseases, 2002
OBJECTIVES: Permeation of cyclosporin A (CsA) through intact and de‐epithelialized human vaginal mucosa in the presence and absence of benzalkonium chloride (BZCl) was tested.MATERIALS AND METHODS: Human vaginal mucosa (snap‐frozen in liquid nitrogen, stored at −85°C) had been used for permeability experiments.
P, van der Bijl, A D, van Eyk, A A, Gareis, I O C, Thompson   +3 more
openaire   +3 more sources

The Impact of Permeation Enhancers on Transcellular Permeation of Small Molecule Drugs

The Journal of Physical Chemistry B
Passive permeation through an epithelial membrane may be enhanced by using a class of amphiphilic molecules known as permeation enhancers (PEs). PEs have been studied in clinical trials and used in coformulations with peptides and small molecule drugs, and yet, an understanding of the permeant-PE interactions leaves much to be desired.
Mabel Bernaldez, Christopher Kang, Stephen D. Stamatis, John P. Rose, Rui Sun   +4 more
openaire   +2 more sources

Mechanisms of oral permeation enhancement

International Journal of Pharmaceutics, 1997
This paper reviews the effects of a diverse range of penetration enhancers, including fatty acids, bile salts, surfactants, Azone® and ethanol, on oral mucosa. We describe in detail the effects on the intercellular lipid domains, the changes induced in proteinaceous regions and potential interactions between the enhancer and endogenous structures along
Ganem-Quintanar, A., Kalia, Yogeshvar, Falson-Rieg, F., Buri, Pierre   +3 more
openaire   +2 more sources

[Influence of permeation enhancers on transdermal permeation of anemonin].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2008
To investigate the effect of different permeation enhancer on transdermal permeation of anemonin through human skin.The permeation experiments were performed using human skin on modified Franz diffusion cells in vitro. The concentrations of anemonin in receptor compartment at specified time points were determined by HPLC.
Yu-Ming, Ning, Yue-Feng, Rao, Wen-Quan, Liang   +2 more
openaire   +1 more source

Combining Chemical Permeation Enhancers for Synergistic Effects

European Journal of Drug Metabolism and Pharmacokinetics, 2015
Currently, macromolecular drugs such as proteins are mainly administered by means of injections due to their low intestinal epithelial permeability and poor stability in the gastrointestinal tract. This study investigated binary combinations of chemical drug absorption enhancers to determine if synergistic drug absorption enhancement effects exist ...
Trizel du Toit, Maides M. Malan, Hendrik J. R. Lemmer, Chrisna Gouws, Marique E. Aucamp, Wilma J. Breytenbach, Josias H. Hamman   +6 more
openaire   +3 more sources

Polymeric Permeation Enhancers

2009
There are enough low molecular permeation enhancers available to increase the absorption of hydrophilic drugs, but all of them have the disadvantage of strongly interfering with the phospholipid membranes and of damaging them. Polymeric permeation enhancers are a class of substances which are able to selectively trigger mechanisms to selectively open ...
openaire   +1 more source

Transdermal self-permeation enhancement of ibuprofen

Journal of Controlled Release, 2004
The objective of this study was to prepare saturated solutions of ibuprofen, of different concentrations, and to investigate their effect on permeation of ibuprofen across rat epidermis. Ibuprofen saturated solutions were prepared using 0.1, 0.2, 0.3 and 0.4 M disodium hydrogen phosphate solution (DHP).
openaire   +2 more sources

Mechanistic Studies of Permeation Enhancers

2005
Effective methodologies are required for the mechanistic studies of chemical permeation enhancers in topical and transdermal drug delivery. Our previous studies have employed a systematic approach (a symmetric and equilibrium configuration) to study the mechanisms of action of chemical permeation enhancers for permeation across the lipoidal pathway of ...
William Higuchi, S Kevin Li
openaire   +2 more sources

Permeation Enhancers

2021
Diego Iacovone, Marcelo Nacucchio
openaire   +1 more source