Permeation enhancer-induced membrane defects assist the oral absorption of peptide drugs [PDF]
Nature CommunicationsThe passive membrane permeation of small-molecule drugs and small hydrophobic peptides is relatively well understood. In contrast, how long polar peptides can pass through a membrane has remained a mystery.
Kyle J. Colston +2 more
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Permeation Enhancer in Microemulsions and Microemulsion-Based Gels: A Comparison of Diethylene Glycol Monoethyl Ether and Oleyl Alcohol [PDF]
GelsMicroemulsions have been commonly used with various permeation enhancers to improve permeability through the skin. The purpose of this study was to compare the release and permeation ability of two commonly used permeation enhancers—diethylene glycol ...
Sujata Pandey, Gabriella Baki
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In Vitro and Ex Vivo Evaluation of Penetratin as a Non-invasive Permeation Enhancer in the Penetration of Salmon Calcitonin through TR146 Buccal Cells and Porcine Buccal Tissues [PDF]
Pharmaceuticals, 2020 Buccal tissues are considered one of the potential alternative delivery route because of fast drug absorption and onset of action due to high vascularization and a non-keratinized epithelial membrane.
Taekwang Keum +4 more
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Pharmaceutics, 2021 Ophthalmic drug delivery is still a challenge due to the protective barriers of the eye. A common strategy to promote drug absorption is the use of ocular permeation enhancers, while an innovative approach is the use of polymeric micelles. In the present
Giovanna Pitarresi +2 more
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A melatonin textile transdermal patch based on physicochemical synergistic permeation-enhancement strategy for circadian rhythm regulation [PDF]
Frontiers in Bioengineering and BiotechnologyMelatonin, an endogenous circadian rhythm-regulating hormone, has faced challenges in achieving prolonged exogenous regulation due to its low oral bioavailability and short half-life.
Juyang Zhao +9 more
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Impact of peptide permeation enhancer on tight junctions opening cellular mechanisms [PDF]
Biochemistry and Biophysics Reports, 2022 The myristoylated pentapeptide, L-R5, contains an amino acid sequence of the zeta inhibitory peptide (ZIP) portion (pseudosubstrate) of protein kinase C zeta (PKC ζ).
Joël Brunner +4 more
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Novel Chemical Permeation Enhancers for Transdermal Drug Delivery
Asian Journal of Pharmaceutical Sciences, 2014 Transdermal drug delivery has been accepted as a potential non-invasive route of drug administration, with advantages of prolonged therapeutic action, decreased side effect, easy use and better patient compliance.
Yang Chen, Xiaochang Liu, Peng Quan
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Salcaprozate Sodium as a Permeation Enhancer—Mechanism, Applications and Unresolved Questions [PDF]
PharmaceuticsOral absorption remains challenging for peptides, proteins, and other drug substances with limited stability or permeability. Sodium N-(8-[2-hydroxybenzoyl]amino)caprylate (SNAC), also known as salcaprozate sodium, is an oral permeation enhancer used in ...
Boris Dinkov +2 more
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Development of eucalyptol enriched nano vesicles for better transdermal delivery of curcumin: Preparation, characterisation and ex vivo skin analysis [PDF]
Nanomedicine Journal, 2022 Objective(s): Invasomes are nano-sized vesicular systems made of ethanol, soybean phosphatidylcholine and terpenes that promote skin penetration by disrupting the lipoidal structure of stratum corneum, interacting with the matrix proteins and augmenting ...
Bhumika Kumar +2 more
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Future Journal of Pharmaceutical Sciences, 2021 Background Present investigation for research was to develop matrix-type transdermal drug delivery system of flurbiprofen (FBP) with the various ratio of matrix polymers (hydrophilic and hydrophobic), the concentration of plasticizer and natural ...
Ramakant Joshi, Navneet Garud
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