Effect of Paracellular Permeation Enhancers on Intestinal Permeability of Two Peptide Drugs, Enalaprilat and Hexarelin, in Rats [PDF]
Acta Pharmaceutica Sinica B, 2021 Transcellular permeation enhancers are known to increase the intestinal permeability of enalaprilat, a 349 Da peptide, but not hexarelin (887 Da). The primary aim of this paper was to investigate if paracellular permeability enhancers affected the ...
Mikael Hedeland +2 more
exaly +5 more sources
Inulin-Based Polymeric Micelles Functionalized With Ocular Permeation Enhancers: Improvement of Dexamethasone Permeation/Penetration Through Bovine Corneas [PDF]
Pharmaceutics, 2021 Ophthalmic drug delivery is still a challenge due to the protective barriers of the eye. A common strategy to promote drug absorption is the use of ocular permeation enhancers, while an innovative approach is the use of polymeric micelles. In the present
Giovanna Pitarresi +2 more
exaly +6 more sources
Buccal Permeation of Polysaccharide High Molecular Weight Compounds: Effect of Chemical Permeation Enhancers [PDF]
Pharmaceutics, 2022 The greatest achievement in the advanced drug delivery field should be the optimization of non-invasive formulations for the delivery of high molecular weight compounds.
Adriana Fantini +7 more
doaj +5 more sources
Long‐term daily oral administration of intestinal permeation enhancers is safe and effective in mice [PDF]
Bioengineering & Translational Medicine, 2023 Although protein drugs are powerful biologic therapeutics, they cannot be delivered orally because their large size and hydrophilicity limit their absorption across the intestinal epithelium.
Katherine C. Fein +6 more
doaj +3 more sources
Gastrointestinal Permeation Enhancers for the Development of Oral Peptide Pharmaceuticals [PDF]
Pharmaceuticals, 2022 Recently, two oral-administered peptide pharmaceuticals, semaglutide and octreotide, have been developed and are considered as a breakthrough in peptide and protein drug delivery system development.
Jae Cheon Kim, Eun Ji Park, Dong Hee Na
doaj +3 more sources
Current Status of Amino Acid-Based Permeation Enhancers in Transdermal Drug Delivery [PDF]
Membranes, 2021 Transdermal drug delivery (TDD) presents many advantages compared to other conventional routes of drug administration, yet its full potential has not been achieved.
Rui Pereira +4 more
doaj +3 more sources
Regional Intestinal Drug Permeability and Effects of Permeation Enhancers in Rat [PDF]
Pharmaceutics, 2020 Sufficient colonic absorption is necessary for all systemically acting drugs in dosage forms that release the drug in the large intestine. Preclinically, colonic absorption is often investigated using the rat single-pass intestinal perfusion model.
David Dahlgren +5 more
doaj +4 more sources
N-Alkylmorpholines: Potent Dermal and Transdermal Skin Permeation Enhancers [PDF]
Pharmaceutics, 2021 Transdermal drug delivery is an attractive non-invasive method offering numerous advantages over the conventional routes of administration. The main obstacle to drug transport is, however, the powerful skin barrier that needs to be modulated, for example,
Kristýna Dvořáková +3 more
doaj +3 more sources
Ionic Liquids as Potential and Synergistic Permeation Enhancers for Transdermal Drug Delivery [PDF]
Pharmaceutics, 2019 Transdermal drug delivery systems (TDDS) show clear advantages over conventional routes of drug administration. Nonetheless, there are limitations to current TDDS which warrant further research to improve current TDD platforms.
Lisa C du Toit +2 more
exaly +4 more sources
Topical Ocular Drug Delivery: The Impact of Permeation Enhancers [PDF]
PharmaceuticsTopical ophthalmic drug delivery targeting the posterior segment of the eye has become a key area of interest due to its non-invasive nature, safety, ease of application, patient compliance, and cost-effectiveness.
Gonçalo Santos +4 more
doaj +2 more sources