Results 41 to 50 of about 136,012 (290)

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Enhanced Transdermal Delivery of Bisoprolol Hemifumarate via Combined Effect of Iontophoresis and Chemical Enhancers: Ex Vivo Permeation/In Vivo Pharmacokinetic Studies

Pharmaceutics, 2021
Bisoprolol hemifumarate (BH) is an antihypertensive drug that is used as first-line treatment for chronic hypertension and angina pectoris. Our study was performed to enhance the transdermal delivery of BH, a hydrophilic drug active with high molecular ...
Mahmoud H. Teaima, Mohamed Azmi Ahmed Mohamed, Randa Tag Abd El Rehem, Saadia A. Tayel, Mohamed A. El-Nabarawi, Shahinaze A. Fouad   +5 more
doaj   +1 more source

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

FEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui, Agnes Banreti, Armelle L. Ernst, Guillaume Leseigneur, Uwe J. Meierhenrich   +4 more
wiley   +1 more source

Design, development and permeation studies of nebivolol hydrochloride from novel matrix type transdermal patches

Advanced Biomedical Research, 2013
Background : Nebivolol hydrochloride is a third generation β-blocker with highly selective β1 -receptor antagonist with antihypertensive properties having plasma half life of 10 h and 12% oral bioavailability.
Vijay Singh Jatav, Jitender Singh Saggu, Ashish Kumar Sharma, Anil Sharma, Rakesh Kumar Jat   +4 more
doaj   +1 more source

Investigation on utility of some novel terpenes on transungual delivery of terbinafine for the management of onychomycosis

Dermatology Practical & Conceptual, 2022
Introduction: Onychomycosis is a fungal disorder of the nail which afflicts 5% of the population worldwide. The disease is strenuous to cure as it is chronic, hard to eliminate and tends to recur. Topical therapy is at the forefront for the treatment of
Isha Gupta, Syeda Nashvia Adin, Mohd Aqil, Mohd Mujeeb, Yasmin Sultana   +4 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Formulation and Optimization of Nanoemulsions Loaded with Gamma−Aminobutyric Acid (GABA) for Dermatological Application: Assessing Skin Permeation and Penetration Enhancement

Cosmetics
Gamma−aminobutyric acid (GABA) presents several potential skin benefits, but its water−soluble nature poses challenges for effectively penetrating the skin to produce its effects. This research aimed to improve GABA’s skin penetration and availability by
Dusadee Charnvanich, Kamonwan Singpanna, Vipaporn Panapisal   +2 more
doaj   +1 more source

Transdermal drug delivery of labetalol hydrochloride: Feasibility and effect of penetration enhancers

Journal of Pharmacy and Bioallied Sciences, 2010
Objectives : The objective of this study is to investigate the feasibility of transdermal drug delivery of Labetalol Hydrochloride (LHCl) and to study the effect of different penetration enhancers on the skin permeability of LHCl.
Saqib Zafar, Asgar Ali, Mohammed Aqil, Abdul Ahad   +3 more
doaj   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Optimization and Characterization of Chitosan Films for Transdermal Delivery of Ondansetron

Molecules, 2013
The aim of this study was to develop novel transdermal films of ondansetron HCl with high molecular weight chitosan as matrix polymer and 2-(2-ethoxy-ethoxy) ethanol (Transcutol®) as plasticizer. In this context, firstly the physicochemical properties of
Yıldız Özsoy, Sevgi Güngör, Meryem Sedef Erdal, Aslı Sedef Can   +3 more
doaj   +1 more source