Results 51 to 60 of about 146,309 (266)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Extensive transcription analysis of the Hyposoter didymator Ichnovirus genome in permissive and non-permissive lepidopteran host species. [PDF]

PLoS ONE, 2014
Ichnoviruses are large dsDNA viruses that belong to the Polydnaviridae family. They are specifically associated with endoparasitic wasps of the family Ichneumonidae and essential for host parasitization by these wasps.
Tristan Dorémus, François Cousserans, Gabor Gyapay, Véronique Jouan, Patricia Milano, Eric Wajnberg, Isabelle Darboux, Fernando Luis Cônsoli, Anne-Nathalie Volkoff   +8 more
doaj   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

New capsaicin analogs as molecular rulers to define the permissive conformation of the mouse TRPV1 ligand-binding pocket

eLife, 2020
The capsaicin receptor TRPV1 is an outstanding representative of ligand-gated ion channels in ligand selectivity and sensitivity. However, molecular interactions that stabilize the ligand-binding pocket in its permissive conformation, and how many ...
Simon Vu, Vikrant Singh, Heike Wulff, Vladimir Yarov-Yarovoy, Jie Zheng   +4 more
doaj   +1 more source

α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates

FEBS Letters, EarlyView.
Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino, Giuliana Fusco, Alfonso De Simone   +2 more
wiley   +1 more source

Varying strategies for processing “loose” argument structure in West Germanic languages

Frontiers in Language Sciences
Permissive subjects are non-agentive subjects combined with action verbs in the active form (e. g., “A few years ago a penny would buy you two or three pins”; “The tentsleeps four people”), hardly found in German compared to English.
Anne Renzel, Gunther De Vogelaer, Jens Bölte   +2 more
doaj   +1 more source

Permissive underfeeding, cytokine profiles and outcomes in critically ill patients.

PLoS ONE, 2019
BackgroundDuring critical illness in humans, the effects of caloric restriction on the inflammatory response are not well understood. The aim of this study is to examine the associations of caloric restriction, inflammatory response profiles and outcomes
Yaseen Arabi, Dunia Jawdat, Abderrezak Bouchama, Hani Tamim, Waleed Tamimi, Mohammed Al-Balwi, Hasan M Al-Dorzi, Musharaf Sadat, Lara Afesh, Mashan L Abdullah, Walid Mashaqbeh, Maram Sakhija, Mohamed A Hussein, Adila ElObeid, Abdulaziz Al-Dawood   +14 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Permissive beliefs in the context of gaming, online shopping and alcohol drinking – Systematic development of a self-report measure

Comprehensive Psychiatry
Background: The activation of permissive beliefs is a cognitive mechanism through which individuals permit themselves to engage in pleasurable, yet potentially unregulated activities.
Annika Brandtner, Silke M. Müller, Sofie Behrens, Andreas Oelker, Matthias Brand   +4 more
doaj   +1 more source