Results 61 to 70 of about 192,401 (288)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Extensive transcription analysis of the Hyposoter didymator Ichnovirus genome in permissive and non-permissive lepidopteran host species. [PDF]

PLoS ONE, 2014
Ichnoviruses are large dsDNA viruses that belong to the Polydnaviridae family. They are specifically associated with endoparasitic wasps of the family Ichneumonidae and essential for host parasitization by these wasps.
Tristan Dorémus, François Cousserans, Gabor Gyapay, Véronique Jouan, Patricia Milano, Eric Wajnberg, Isabelle Darboux, Fernando Luis Cônsoli, Anne-Nathalie Volkoff   +8 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Permissive underfeeding, cytokine profiles and outcomes in critically ill patients.

PLoS ONE, 2019
BackgroundDuring critical illness in humans, the effects of caloric restriction on the inflammatory response are not well understood. The aim of this study is to examine the associations of caloric restriction, inflammatory response profiles and outcomes
Yaseen Arabi, Dunia Jawdat, Abderrezak Bouchama, Hani Tamim, Waleed Tamimi, Mohammed Al-Balwi, Hasan M Al-Dorzi, Musharaf Sadat, Lara Afesh, Mashan L Abdullah, Walid Mashaqbeh, Maram Sakhija, Mohamed A Hussein, Adila ElObeid, Abdulaziz Al-Dawood   +14 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Varying strategies for processing “loose” argument structure in West Germanic languages

Frontiers in Language Sciences
Permissive subjects are non-agentive subjects combined with action verbs in the active form (e. g., “A few years ago a penny would buy you two or three pins”; “The tentsleeps four people”), hardly found in German compared to English.
Anne Renzel, Gunther De Vogelaer, Jens Bölte   +2 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Refractory and permissive periods during single cycles.

, 2021
(A) (Left) Scatter plot of REMpre vs. ln(|N|) along with boundary (solid line) separating the refractory from the permissive period within single cycles.
Justin Baik (11331497), Benjamin Kurland (11331500), Franz Weber (356782), Jiso Hong (10971037), Shinjae Chung (213308), Hanna Antila (179970), Sung-Ho Park (11331494)   +6 more
core   +1 more source

Concept and peculiarities of permissive proceeding [PDF]

, 2018
У статті досліджуються проблеми щодо визначення поняття дозвільного провадження, його змісту та системи правового регулювання. Проаналізовано підходи різних вчених щодо визначення категорій «дозвільна система» і «дозвільні відносини», їх співвідношення
Хатнюк, Ю. А., Кіцул, Ю. С.   +1 more
core   +2 more sources