Results 91 to 100 of about 66,692 (339)

Host natural killer immunity is a key indicator of permissiveness for donor cell engraftment in patients with severe combined immunodeficiency

Journal of Allergy and Clinical Immunology, 2014
Background Severe combined immunodeficiency (SCID) can be cured by using allogeneic hematopoietic stem cell transplantation, and the absence of host immunity often obviates the need for preconditioning. Depending on the underlying genetic defect and when
Amel Hassan, P. Lee, P. Maggina, Jin Xu, D. Moreira, M. Slatter, Z. Nademi, A. Worth, S. Adams, A. Jones, C. Cale, Z. Allwood, K. Rao, R. Chiesa, P. Amrolia, H. Gaspar, E. Davies, P. Veys, A. Gennery, W. Qasim   +19 more
semanticscholar   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Dysregulation of Retinoic Acid Receptor Diminishes Hepatocyte Permissiveness to Hepatitis B Virus Infection through Modulation of Sodium Taurocholate Cotransporting Polypeptide (NTCP) Expression*

Journal of Biological Chemistry, 2014
Background: Host factors regulating hepatitis B virus (HBV) entry receptors are not well defined. Results: Chemical screening identified that retinoic acid receptor (RAR) regulates sodium taurocholate cotransporting polypeptide (NTCP) expression and ...
Senko Tsukuda, Koichi Watashi, Masashi Iwamoto, R. Suzuki, H. Aizaki, Maiko Okada, M. Sugiyama, S. Kojima, Yasuhito Tanaka, M. Mizokami, Jisu Li, S. Tong, T. Wakita   +12 more
semanticscholar   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Personality Traits and Sexual Attitudes as Predictors of Risky Sexual Behaviors in Health Science Students

Youth
Previous research suggests that certain personality traits, such as extraversion and openness, may be associated with sexual risk behaviors (SRB).
María Naranjo-Márquez, Anna Bocchino, Ester Gilart, Eva Manuela Cotobal-Calvo, Concepción Mata-Pérez, José Luis Palazón-Fernández   +5 more
doaj   +1 more source

Permissiveness and control (Book Review)

, 1981
reviewA review of the book "Permissiveness and Control"
Francis, Leslie
core  

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Attitudes of family planning workers toward teenage sexual permissiveness

, 1979
Includes bibliographical references (leaves 158-168)The problem of this study was to compare family planning workers' attitudes toward teenage sexual permissiveness with agency and agency personnel characteristics. Procedures used in this study consisted
Fields, Tina Taylor
core  

Plasmid permissiveness of wastewater microbiomes can be predicted from 16S rRNA sequences by machine learning [PDF]

, 2023
\ua9 The Author(s) 2023. Motivation: Wastewater treatment plants (WWTPs) harbor a dense and diverse microbial community. They constantly receive antimicrobial residues and resistant strains, and therefore provide conditions for horizontal gene transfer ...
Sorensen SJ, Dechesne A, Smets BF, Moradigaravand D, de la Cruz R, Banzhaf M, Kreft J-U, Nesme J, Ahmad H, Li L   +9 more
core