Results 111 to 120 of about 66,692 (339)
Permissiveness of human hepatoma cell lines for HCV infection
Virology Journal, 2012 Background Although primary and established human hepatoma cell lines have been evaluated for hepatitis C virus (HCV) infection in vitro, thus far only Huh7 cells have been found to be highly permissive for infectious HCV.
Sainz Bruno +4 more
doaj +1 more source
Human Brain Mapping, 2014 Sexual behavior is a critical function of human procreation. Despite previous studies that investigated the neural mechanisms of basic human physiological sexual functions, the neural mechanisms that underlie individual differences in human sexual ...
H. Takeuchi +9 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Premarital sexual permissiveness among adolescent males living in Cabuyao, Laguna
, 2011 This paper studies how sexual permissiveness is observable through its different factor, and their manifestations in the differences and similarities between barangays (context areas) that are considered to be (a) rural, (b) urban, and (c) rural-urban ...
De Leon, Benjamin Francis +1 more
core
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
PLoS ONE, 2014 Hepatitis C Virus (HCV) is a serious global health problem, infecting almost 3% of the world's population. The lack of model systems for studying this virus limit research options in vaccine and therapeutic development, as well as for studying the ...
Patricia A Thibault, Joyce A Wilson
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Sand Fly–Associated Phlebovirus with Evidence of Neutralizing Antibodies in Humans, Kenya
Emerging Infectious Diseases, 2019 We describe a novel virus, designated Ntepes virus (NPV), isolated from sand flies in Kenya. NPV has the characteristic phlebovirus trisegmented genome architecture and is related to, but distinct from, Gabek Forest phlebovirus.
David P. Tchouassi +11 more
doaj +1 more source
Permissive Metaepistemology [PDF]
Mind, 2018 AbstractRecent objections to epistemic permissivism have a metaepistemic flavor. Impermissivists argue that their view best accounts for connections between rationality, planning and deference. Impermissivism is also taken to best explain the value of rational belief and normative assessment.
openaire +2 more sources
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source