Results 51 to 60 of about 13,329 (248)
IEEE Access, 2019 The noncontact measurement of vital sign signals is useful for medical care, rescuing disaster survivors from ruins and public safety. In this paper, a novel vital sign signal extraction method based on permutation entropy (PE) and ensemble empirical ...
Degui Yang, Zhengliang Zhu, Buge Liang
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Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
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Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Multiscale permutation entropy for two-dimensional patterns
Pattern Recognition Letters, 2021 Abstract Complexity measures are important to understand and analyze systems with one dimensional data. However, extension of these methods to images (two dimensional data) are much less usual. Bidimensional multiscale sample entropy ( M S E 2 D ) has recently been proposed as a new complexity measure for texture evaluation. However,
Morel, Cristina, Humeau-Heurtier, Anne
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Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
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FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
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Numerical and experimental study of the effects of noise on the permutation entropy
New Journal of Physics, 2015 We analyze the effects of noise on the permutation entropy of dynamical systems. We take as numerical examples the logistic map and the Rössler system.
C Quintero-Quiroz +3 more
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Epileptic Seizure Prediction Based on Permutation Entropy [PDF]
Frontiers in Computational Neuroscience, 2018 Epilepsy is a chronic non-communicable disorder of the brain that affects individuals of all ages. It is caused by a sudden abnormal discharge of brain neurons leading to temporary dysfunction. In this regard, if seizures could be predicted a reasonable period of time before their occurrence, epilepsy patients could take precautions against them and ...
Yanli Yang +8 more
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The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
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Fault Recognition Method of Transmission Gear based on Morphological Wavelet and Permutation Entropy
Jixie chuandong, 2019 Based on the in-depth study on morphological wavelet with permutation entropy，a new method for gear of transmission fault recognition is proposed. Firstly，the definition of morphological wavelet is introduced，and the morphological Haar wavelet is used to
Ding Wei +3 more
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