Results 101 to 110 of about 382,738 (264)
On permutations and permutation polytopes [PDF]
, 1978 An easy characterization is given of neighbors on permutation polytopes. Using this characterization it is shown that the graph of any such polytope is Hamiltonian, and that the diameter is two.
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ADAPTIVE REORDERING OF OBSERVATION SPACE TO IMPROVE PATTERN RECOGNITION
TASK Quarterly, 2007 The problem of observation space reordering is presented as a novel approach to pattern recognition based on non-parametric, combinatorial statistical tests. It consists in linearly ordering the elements of a discrete multi-dimensional observation space
JULIUSZ L. KULIKOWSKI
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Permuting Cage, Permuting Music
, 2023 Abstract This chapter explores Mario Lavista’s relationship with U.S. composer John Cage (1912–1992). A close look at Lavista’s adoption of Cage’s philosophy shows that, through performative processes of interpretation and resignification, Cage becomes a symbol, Cage-the-jaula—a container that, far from being restrictive, allows for ...
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Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
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Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
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FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
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Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
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Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
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Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
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Counting permutations where the difference between entries located r places apart can never be s (for any given positive integers r and s) [PDF]
Enumerative Combinatorics and Applications, 2023 George Spahn, Doron Zeilberger
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