Effects of single mutations on the stability of horseradish peroxidase to hydrogen peroxide [PDF]
, 2007 Horseradish peroxidase (HRP) is a commonly used enzyme in many biotechnological fields. Improvement of HRP stability would further increase its potential application range.
Arnold +18 more
core +2 more sources
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Труды по прикладной ботанике, генетике и селекции, 2022 Background. One of the important indicators of the nutritional value of amaranth is the high content of protein and lipids in seeds. Hence, obtaining and identifying such forms of amaranth through breeding, so that they also possessed resistance to ...
R. M. Taipova +3 more
doaj +1 more source
Pharmaceutical and personal care products-induced stress symptoms and detoxification mechanisms in cucumber plants. [PDF]
, 2018 Contamination of agricultural soils by pharmaceutical and personal care products (PPCPs) resulting from the application of treated wastewater, biosolids and animal wastes constitutes a potential environmental risk in many countries.
Dudley, Stacia +3 more
core +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Recent advances in electron transfer between biofilms and metals [PDF]
, 2007 Microbial biofilms produce electrochemical interactions with metal surfaces by following a wide variety of different electron exchange pathways. Reviewing the mechanisms identified in the biocorrosion of steels leads us to distinguish direct and indirect
Bergel, Alain
core +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
The role of total proteins, peroxidases and polyphenoloxidases in metabolismes of Juniperus spp. [PDF]
تحقیقات جنگل و صنوبر ایران, 2000 In this study, role of total proteins, peroxidases and polyphenoloxidases in metabolisms of juniper were studied. For this purpose, seasonal alteration (quantitative and qualitative) of total proteins, peroxidases and polyphenoloxidases from branches ...
Parvin Salehi Shanjani +2 more
doaj +1 more source
Novel biological approaches for the removal of chlorophenolics [AOX] from bleach plant effluent [PDF]
, 2005 No abstract ...
Veeramani, Harish
core
Genomic and proteomic evidences unravel the UV-resistome of the poly-extremophile Acinetobacter sp. Ver3 [PDF]
, 2015 Ultraviolet radiation can damage biomolecules, with detrimental or even lethal effects for life. Even though lower wavelengths are filtered by the ozone layer, a significant amount of harmful UV-B and UV-A radiation reach Earth?s surface, particularly in
Carolina eBelfiore +6 more
core +1 more source