Results 71 to 80 of about 273,396 (304)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Biochemical and Pathological Studies on Peroxidases –An Updated Review

Global Journal of Health Science, 2014
Peroxidases represent a family of isoenzymes actively involved in oxidizing reactive oxygen species, innate immunity, hormone biosynthesis and pathogenesis of several diseases. Different types of peroxidases have organ, tissues, cellular and sub-cellular
A. Khan, A. Rahmani, Y. Aldebasi, S. Aly
semanticscholar   +1 more source

ISOENZYMATIC POLYMORPHISM AND ACTIVITY OF PEROXIDASES OF COMMON BEAN (Phaseolus vulgaris L.) UNDER SALINE STRESS

Scientia Agricola, 1997
One of the uses of the technique of tissue culture for plant breeding is the identification of cell lines tolerant to salt stress.In order to study the biochemical mechanisms involved in the genetic expression to salt tolerance, callus from embryo axis ...
F. BROETTO, A.M. CASA, E. MALAVOLTA, C.R. LOPES   +3 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Turning points in the evolution of peroxidase–catalase superfamily: molecular phylogeny of hybrid heme peroxidases

Cellular and Molecular Life Sciences, 2014
Heme peroxidases and catalases are key enzymes of hydrogen peroxide metabolism and signaling. Here, the reconstruction of the molecular evolution of the peroxidase–catalase superfamily (annotated in pfam as PF00141) based on experimentally verified as ...
M. Zámocký, Bernhard Gasselhuber, P. Furtmüller, C. Obinger   +3 more
semanticscholar   +1 more source

Genome-Wide Characterization of Class III Peroxidases and Their Expression Profile During Mycorrhizal Symbiosis and Phosphorus Deprivation in Lettuce (Lactuca sativa L.)

Horticulturae
Lettuce cultivation requires high fertilizer inputs, which impact the environment and costs. Arbuscular mycorrhizal symbiosis (AMS) can reduce fertilizer use, enhance plant nutrition (especially phosphorus), and promote healthier plants.
Samuel Simoni, Marco Castellacci, Gabriele Usai, Ugo Rogo, Flavia Mascagni, Tommaso Giordani, Lucia Natali, Andrea Cavallini, Alberto Vangelisti   +8 more
doaj   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Control of Postharvest Performance of the Lilacs ‘Andenken an Ludwig Spaeth’ Induced to Flower in Spring

Agriculture
Common lilac (Syringa vulgaris) is an important cut flower on the flower market. The process of forcing shrub is crucial for lilac availability for floristry for six months of the year: from November to April.
Ewa Skutnik, Aleksandra Łukaszewska, Diana Musiał, Agnieszka Zawadzińska, Piotr Salachna, Julita Rabiza-Świder   +5 more
doaj   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Benzoxazinoids stimulate chemotaxis and act as a signaling molecule in Azospirillum brasilense Ab-V5, while showing minor effects on Pseudomonas protegens Pf-5

mBio
Root colonization by plant growth-promoting bacteria (PGPB) involves recruiting beneficial partners from the rhizosphere. Among well-studied PGPB, Azospirillum brazilense Ab-V5 and Pseudomonas protegens Pf-5 are two well-known bacterial strains renowned ...
Jeroen Baatsen, Guilherme K. Hosaka, Mateus Mondin, João L. Azevedo, Mariangela Hungria, Maria C. Quecine   +5 more
doaj   +1 more source