Results 51 to 60 of about 81,876 (307)

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Ligninolytic enzyme potential of Trametes spp. associated with leaf litter in riparian forest of the Amazônia region [PDF]

Brazilian Journal of Biology
The present study explored the potential of leaf litter as a source of fungi able to produce ligninolytic enzymes for the biodegradation of anthraquinone dyes. Within the colonies isolated from the leaf litter, only three colonies of two species Trametes
I. A. L. De Sousa, A. J. Boari, A. S. Santos   +2 more
doaj   +1 more source

Changes in the content of proteins and lipids and in the state of the antioxidant system in mutant forms of Amaranthus cruentus L.

Труды по прикладной ботанике, генетике и селекции, 2022
Background. One of the important indicators of the nutritional value of amaranth is the high content of protein and lipids in seeds. Hence, obtaining and identifying such forms of amaranth through breeding, so that they also possessed resistance to ...
R. M. Taipova, V. N. Nesterov, O. A. Rozentsvet, B. R. Kuluev   +3 more
doaj   +1 more source

A novel aspect of essential oils: coating seeds with thyme essential oil induces drought resistance in wheat [PDF]

, 2019
Coating seeds with biostimulants is among the promising approaches in crop production to increase crop tolerance to drought stress. In this study, we evaluated the potential of coating durum wheat seeds of the cultivar ‘Karim’ with thyme essential oil on
Alesami, Noura, Araus Ortega, José Luis, Ben-Jabeur, Maissa, Djébali, Naceur, Gracia-Romero, Adrian, Hamada, Walid, López Carbonell, Marta, López Cristoffanini, Camilo Alonso, Serret Molins, M. Dolors, Vicente, Rubén   +9 more
core   +2 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Novel biological approaches for the removal of chlorophenolics [AOX] from bleach plant effluent [PDF]

, 2005
No abstract ...
Veeramani, Harish
core  

Degradation of lignin β-aryl ether units in Arabidopsis thaliana expressing LigD, LigF and LigG from Sphingomonas paucimobilis SYK-6 [PDF]

, 2017
Lignin is a major polymer in the secondary plant cell wall and composed of hydrophobic interlinked hydroxyphenylpropanoid units. The presence of lignin hampers conversion of plant biomass into biofuels; plants with modified lignin are therefore being ...
Bent, Board, Boerjan, Bonawitz, Bonawitz, Borkhardt, Buanafina, Davin, Dima, Dixon, Dixon, El Amrani, Felipe, Foyer, Gall, Gall, Geu-Flores, Geu-Flores, Goodin, Hause, Herbers, Huang, Kirk, Lallement, Lallement, Lazo, Li, Liu, Liu, Lu, Lu, Mansfield, Masai, Masai, Matsuda, Meux, Morreel, Morreel, Niculaes, Otter, Pauly, Rahimi, Ralph, Ralph, Rogers, Samalova, Sato, Sederoff, Shen, Sonoki, Strack, Tsuji, Van Acker, Vanholme, Vanholme, Vanholme, Vanholme, Vogel, Welinder, Weng, Øbro, Øbro   +61 more
core   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

The role of total proteins, peroxidases and polyphenoloxidases in metabolismes of Juniperus spp. [PDF]

تحقیقات جنگل و صنوبر ایران, 2000
In this study, role of total proteins, peroxidases and polyphenoloxidases in metabolisms of juniper were studied. For this purpose, seasonal alteration (quantitative and qualitative) of total proteins, peroxidases and polyphenoloxidases from branches ...
Parvin Salehi Shanjani, Soodabeh Ali Ahmad Korori, Hasan Ebrahimzadeh   +2 more
doaj   +1 more source