Results 51 to 60 of about 48,716 (304)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Avaliação da resistência de cultivares de feijoeiro (Phaseolus Vulgaris L.) à ferrugem e mecanismos de defesa elicitados por ulvana contra Uromyces appendiculatus: [dissertação] [PDF]

, 2009
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Agrárias, Programa de Pós-graduação em Recursos Genéticos Vegetais, Florianópolis, 2009Verificou-se a reação de 37 cultivares comercias, crioulos e linhagens de feijoeiro
Borsato, Leandro Camargo
core  

Changes in the content of proteins and lipids and in the state of the antioxidant system in mutant forms of Amaranthus cruentus L.

Труды по прикладной ботанике, генетике и селекции, 2022
Background. One of the important indicators of the nutritional value of amaranth is the high content of protein and lipids in seeds. Hence, obtaining and identifying such forms of amaranth through breeding, so that they also possessed resistance to ...
R. M. Taipova, V. N. Nesterov, O. A. Rozentsvet, B. R. Kuluev   +3 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Three differentially expressed basic peroxidases from wound-lignifying ¤Asparagus officinalis¤

, 2003
The activity of ionically bound peroxidases from an asparagus spear increased from 5-24 h post-harvest. Isoelectric focusing showed that the post-harvest increase of the total peroxidase activity was due to the increase of several distinct isoperoxidases.
Rasmussen, Søren K., Eckloff, Reinhard M.G., Rasmussen, S.K., Kristensen, Brian K., Holm, Kirsten B., Kristensen, B.K., Andreasen, P.H., Eckloff, R., Andreasen, Per H., Holm, K.B.   +9 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Phenol oxidation by DyP-type peroxidases in comparison to fungal and plant peroxidases

, 2014
Over the last years, novel peroxidases secreted by lignocellulose-degrading agaricomycetes have been discovered. Among them, the so-called DyP-type peroxidases (DyPs) that are secreted under conditions close to nature (i.e.
Zorn, Holger, Hofrichter, Martin, Liers, Christiane, Aranda, Elizabet, Strittmatter, Eric, Piontek, Klaus, Plattner, Dietmar A., Ullrich, René   +7 more
core   +1 more source

The role of total proteins, peroxidases and polyphenoloxidases in metabolismes of Juniperus spp. [PDF]

تحقیقات جنگل و صنوبر ایران, 2000
In this study, role of total proteins, peroxidases and polyphenoloxidases in metabolisms of juniper were studied. For this purpose, seasonal alteration (quantitative and qualitative) of total proteins, peroxidases and polyphenoloxidases from branches ...
Parvin Salehi Shanjani, Soodabeh Ali Ahmad Korori, Hasan Ebrahimzadeh   +2 more
doaj   +1 more source

Peroxidase and peroxidase-oxidase activities of isolated human myeloperoxidases [PDF]

Biochemical Journal, 1987
Isolated neutrophils from healthy donors were used for the isolation of four highly purified forms of myeloperoxidase as determined by spectral (A430/A280 ratio 0.80-0.87) and enzyme-activity measurements. Although the myeloperoxidases exhibited different elution profiles on cation-exchange chromatography, gel filtration indicated similar relative ...
B E, Svensson, K, Domeij, S, Lindvall, G, Rydell   +3 more
openaire   +2 more sources

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source