Results 171 to 180 of about 19,535 (281)

Oxidative Stress and DNA Epigenetic Modifications in Cancer: Mechanisms and Targeted Therapeutics

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Reactive oxygen species (ROS) modulate DNA methyltransferases (DNMTs), ten‐eleven translocation family proteins (TETs) and their cofactors, reshaping 5‐methylcytosine (5mC)/5‐hydroxymethylcytosine (5hmC)/5‐formylcytosine (5fC) landscapes and gene expression in cancer cells. In turn, epigenetic control of antioxidant and metabolic pathways feeds back on
Xishan Yang, Qitai Chen, YuJie Yu, Yi Zang, Rujia Zheng, Zhe Zhang, Shuaijun Lu, Li Zhou   +7 more
wiley   +1 more source

Hetero-oligomerization drives structural plasticity of eukaryotic peroxiredoxins. [PDF]

Nat Chem Biol
Zimmermann J, Lang L, Malo Pueyo J, Riedel M, Wahni K, Stobbe D, Leiskau L, Aref E, Lux C, Janvier S, Vertommen D, Lenhard S, Hannemann F, Thangamuragan S, Castro H, Helms V, Tomas AM, Herrmann JM, Salvador A, Mühlhaus T, Riemer J, Messens J, Deponte M, Morgan B.   +23 more
europepmc   +1 more source

Oxidative Stress in the Tumor Immune Microenvironment: Mechanisms and Therapeutic Perspectives

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Oxidative stress is involved in several key processes in cancer, including redox regulation, DNA damage, post‐translational modifications, transcriptional regulation, epigenetic modifications, metabolic reprogramming, cell death, and immune modulation. These mechanisms collectively influence tumor progression, immune evasion, and therapeutic responses,
Zhen Wang, Bowen Li, Pan Tang, Fanchen Yan, Shuxin Wang, Guiying Leng, Panduo Dawa, Yuansi Chen, Yihan Guo, Pan Yang, Yi Li, Siyu Liu, Erdan Dong, Siyuan Qin, Zhoufeng Wang   +14 more
wiley   +1 more source

Fasting requires Peroxiredoxin 2 and Peroxiredoxin 6 to coordinate redox dependent mitochondrial and lipid remodelling in Caenorhabditis elegans. [PDF]

Redox Biol
Li P, Zheng Y, Casas-Martinez JC, Xia Q, Miranda-Vizuete A, Goljanek-Whysall K, McDonagh B.   +6 more
europepmc   +1 more source

Aging‐Related Muscle Bmal1 Decline Contributes to Bone Loss in Mice via Enhancing IL‐1α–Mediated Osteoclastogenesis

Aging Cell, Volume 25, Issue 6, June 2026.
Aging‐related decline of muscle Bmal1 drives bone loss in mice by disrupting Hmox1 and increasing IL‐1α, which promotes osteoclast activity. Time‐restricted feeding reestablishes diurnal Hmox1 expression, reduces IL‐1α, and alleviates osteoporosis, offering a potential therapeutic strategy. ABSTRACT Osteoporosis, a common metabolic bone disorder linked
Kai Huang, Jun Qian, Yike Wang, Feng Zhang, Youjia Xu, Qiaocheng Zhai   +5 more
wiley   +1 more source

Lipopolysaccharide Upregulates Neuroinflammation, Oxidative Stress Responses, and Peroxiredoxins in Depression Models. [PDF]

Brain Behav
Zhang Z, Li N, Liang M, Qin F, Qin Q, He Q, Wang K, Shi X, Jiang Y, Qin H.   +9 more
europepmc   +1 more source

Red blood cell membrane proteome as a reporter of disease severity, transfusion impact and genetic background in transfusion‐dependent β‐thalassaemia

British Journal of Haematology, Volume 208, Issue 6, Page 1980-1992, June 2026.
Summary Omics technologies have transformed research in haemoglobinopathies, yet the proteome of RBCs remains largely unexplored in transfusion‐dependent thalassaemia (TDT). In this proteomic analysis, Red blood cell (RBC) membranes from 48 adults with TDT were compared with healthy controls.
Konstantina Theocharaki, Sophia Delicou, Aikaterini Ntzoura‐Kani, Nikolaos Simantiris, Marianna Politou, Veroniki Komninaka, Martina Samiotaki, Jerome Zoidakis, Marianna H. Antonelou   +8 more
wiley   +1 more source

Dysregulated Peroxiredoxins in Bladder Cancer Are Associated With an Altered Tumour Immune Microenvironment. [PDF]

J Cell Mol Med
Wallerson J, Rostampour S, Teng S, Kidane D.   +3 more
europepmc   +1 more source

The Underlying Mechanisms and Role of Negative Pressure Wound Therapy in Chronic Diabetic Wound Healing: A Systematic Review and Meta‐Analysis

International Wound Journal, Volume 23, Issue 6, June 2026.
ABSTRACT Although Negative Pressure Wound Therapy (NPWT) has been increasingly used in wound care to improve impaired healing, there is little scientific evidence supporting its role and underlying biomolecular mechanisms. Aims of the present study are to provide a quantitative analysis of recent literature investigating NPWT in diabetic wound healing ...
Roxana Moscalu, Mihaela Moscalu, Adam J. Reid, Marco Domingos, Adam Stevens, Jason K. F. Wong   +5 more
wiley   +1 more source

Peroxiredoxin-Mediated Redox Regulation in Neurons: From Neurite Development to Degeneration. [PDF]

Antioxidants (Basel)
Kim G, Lee J, Kwon S, Yeom E, Lee DS.
europepmc   +1 more source