Results 61 to 70 of about 9,422 (217)

Subchronic Exposure to Arsenic and Nickel Triggers Nitrosative Stress and Histological Alterations in the Rat Liver

Journal of Applied Toxicology, EarlyView.
ABSTRACT Environmental exposure to heavy metals poses a threat to human health. Several studies documented harmful effects on the liver after arsenic and nickel exposure at concentrations beyond permissible limits. Nevertheless, the impact of a simultaneous exposure to both elements on hepatic biochemistry and histology remains unelucidated. Therefore,
Thainá Iasbik‐Lima, Luiz Otávio Guimarães‐Ervilha, Isabela Pereira da Silva Bento, Renê Chagas da Silva, Mariana Machado‐Neves   +4 more
wiley   +1 more source

Redox regulation of mammalian sperm capacitation

Asian Journal of Andrology, 2015
Capacitation is a series of morphological and metabolic changes necessary for the spermatozoon to achieve fertilizing ability. One of the earlier happenings during mammalian sperm capacitation is the production of reactive oxygen species (ROS) that will ...
Cristian O′Flaherty
doaj   +1 more source

Plasma Proteomic Profiling Identifies Candidate Biomarkers for Pancreatic Ductal Adenocarcinoma

Journal of Clinical Laboratory Analysis, EarlyView.
Using DIA‐based plasma proteomics followed by ELISA validation, we identified eight circulating proteins that were significantly elevated in patients with pancreatic ductal adenocarcinoma. These proteins reflect key tumor‐associated biological processes, including exocrine dysfunction and immune remodeling, and may serve as candidates for future multi ...
Lelang Xiang, Yi Jin, Ran Hu, Yuhang He, Yong Zhang, Ang Li   +5 more
wiley   +1 more source

Is Overoxidation of Peroxiredoxin Physiologically Significant? [PDF]

Antioxidants & Redox Signaling, 2011
Eukaryotic peroxiredoxins are highly susceptible to sulfinic acid formation. This overoxidation, which is thought to convert peroxiredoxins into chaperones, can be reversed by sulfiredoxins. Several organisms, including Caenorhabditis elegans , lack sulfiredoxins but encode sestrins, proteins
Thamsen, Maike, Kumsta, Caroline, Li, Fei, Jakob, Ursula   +3 more
openaire   +3 more sources

Behavioral mechanisms of mammalian sperm guidance

Asian Journal of Andrology, 2015
In mammals, sperm guidance in the oviduct appears essential for successful sperm arrival at the oocyte. Hitherto, three different potential sperm guidance mechanisms have been recognized: thermotaxis, rheotaxis, and chemotaxis, each of them using ...
Serafín Pérez Cerezales, Sergii Boryshpolets, Michael Eisenbach   +2 more
doaj   +1 more source

Wine Yeast Peroxiredoxin TSA1 Plays a Role in Growth, Stress Response and Trehalose Metabolism in Biomass Propagation

Microorganisms, 2020
Peroxiredoxins are a family of peroxide-degrading enzymes for challenging oxidative stress. They receive their reducing power from redox-controlling proteins called thioredoxins, and these, in turn, from thioredoxin reductase.
Víctor Garrigós, Cecilia Picazo, Emilia Matallana, Agustín Aranda   +3 more
doaj   +1 more source

Radioprotective Role of Peroxiredoxin 6 [PDF]

Antioxidants, 2019
Peroxiredoxin 6 (Prdx6) is a member of an evolutionary ancient family of peroxidase enzymes with diverse functions in the cell. Prdx6 is an important enzymatic antioxidant. It reduces a wide range of peroxide substrates in the cell, thus playing a leading role in the maintenance of the redox homeostasis in mammalian cells.
Mars G. Sharapov, Vladimir I. Novoselov, Sergey V. Gudkov   +2 more
openaire   +3 more sources

A Peroxiredoxin From the Haemaphysalis longicornis Tick Affects Langat Virus Replication in a Hamster Cell Line

Frontiers in Cellular and Infection Microbiology, 2020
Ticks are hematophagous arthropods, and their blood feeding on vertebrate hosts is essential for their development. The vertebrate blood contains high levels of free iron that can react with oxygen in ticks, resulting in the production of hydrogen ...
Kodai Kusakisako, Kodai Kusakisako, Haruki Morokuma, Melbourne Rio Talactac, Emmanuel Pacia Hernandez, Emmanuel Pacia Hernandez, Kentaro Yoshii, Tetsuya Tanaka, Tetsuya Tanaka   +8 more
doaj   +1 more source

CRISPR/Cas9‐mediated Genome‐editing Reveals 10 Testis‐enriched Genes and One Non‐testis‐enriched Gene are Dispensable for Male Fecundity in Mice

Andrology, EarlyView.
ABSTRACT Background More than 1000 genes have been identified as predominantly expressed in the human testis. Advances in gene editing technologies have enabled the rapid and efficient generation of genetically engineered mice. This approach facilitates the screening of genes essential for spermatogenesis by analyzing knockout mouse models.
Yumiao Qiu, Keisuke Shimada, Masahito Ikawa   +2 more
wiley   +1 more source

A comparative evaluation of semen parameters in pre- and post-Hurricane Katrina human population

Asian Journal of Andrology, 2015
A natural disaster leading to accumulation of environmental contaminants may have substantial effects on the male reproductive system. Our aim was to compare and assess semen parameters in a normospermic population residing in the Southern Louisiana, USA
Caner Baran, Wayne J Hellstrom, Suresh C Sikka   +2 more
doaj   +1 more source