Results 61 to 70 of about 19,535 (281)

The E3 Ligase RNF115 Aggravates Pathological Cardiac Hypertrophy via Ubiquitin‐Mediated Degradation of SPTBN1

Advanced Science, EarlyView.
In response to hypertrophic stimuli, increased c‑JUN phosphorylation upregulates RNF115, leading to SPTBN1 ubiquitination and degradation. which promotes F‑actin depolymerization and YAP activation, driving cardiac hypertrophy. The RNF115 inhibitor DTD effectively suppresses SPTBN1 ubiquitination and cardiac hypertrophy.
Yan Zu, Shiqing Chen, Ji Chen, Liuliu Ruan, Bowen Li, Weijian Chu, Shichen Huang, Dian Yu, Jing Tian, Yuhan Zhao, Yi Han, Xin Tang, Yong Ji   +12 more
wiley   +1 more source

Human sperm chromatin epigenetic potential: genomics, proteomics, and male infertility

Asian Journal of Andrology, 2015
The classical idea about the function of the mammalian sperm chromatin is that it serves to transmit a highly protected and transcriptionally inactive paternal genome, largely condensed by protamines, to the next generation.
Judit Castillo, Josep Maria Estanyol, Josep Lluis Ballescà, Rafael Oliva   +3 more
doaj   +1 more source

Dimeric peroxiredoxins are druggable targets in human Burkitt lymphoma [PDF]

, 2016
Burkitt lymphoma is a fast-growing tumor derived from germinal center B cells. It is mainly treated with aggressive chemotherapy, therefore novel therapeutic approaches are needed due to treatment toxicity and developing resistance. Disturbance of red-ox
Klossowski, Szymon, Gaj, Pawel, Czerwoniec, Anna, Bajor, Małgorzata, Zagozdzon, Radoslaw, Muchowicz, Angelika, Chlebowska, Justyna, Domagala, Antoni, Prochorec-Sobieszek, Monika, Trzeciecka, Anna, Ostaszewski, Ryszard, Barankiewicz, Joanna, Golab, Jakub, Malinowska, Agata, Firczuk, Małgorzata, Gwizdalska, Iwonna, Winiarska, Magdalena, Nowis, Dominika   +17 more
core   +1 more source

Cell therapy comparison of dental pulp stem cells, hepatocytes, and their exosomes for liver fibrosis treatment in rats

Animal Models and Experimental Medicine, EarlyView.
DPSCs, hepatocytes, and exosomes were tested for liver fibrosis therapy. Exosome‐based treatment exhibited superior antioxidative and regenerative effects. Liver enzymes, oxidative stress, and profibrotic markers were significantly reduced. α‐SMA, desmin, and related gene expression were downregulated.
Sahar Rahimi, Seyedeh Mahdieh Khoshnazar, Ali Derakhshani, Nader Shahrokhi   +3 more
wiley   +1 more source

Spatial Cell Death and Oxidative Stress Dynamics in Gas Plasma‐Treated Tumor Tissues

Advanced NanoBiomed Research, EarlyView.
Schematic representation of the four experimental models to study tissue penetration and oxidation. Four tissue models were used. Human pancreatic cancer cells were grown on the chorioallantois membrane of chicken embryos and gas plasma‐treated in ovo, murine colorectal tumor tissue was gas plasma‐exposed ex vivo, murine squamous cell carcinoma cells ...
Anke Schmidt, Shahrzad Rokhsary, Linus Hübner, Lea Miebach, Sander Bekeschus   +4 more
wiley   +1 more source

Mitochondrial peroxiredoxin 3 is more resilient to hyperoxidation than cytoplasmic peroxiredoxins [PDF]

Biochemical Journal, 2009
The Prxs (peroxiredoxins) are a family of cysteine-dependent peroxidases that decompose hydrogen peroxide. Prxs become hyperoxidized when a sulfenic acid formed during the catalytic cycle reacts with hydrogen peroxide. In the present study, Western blot methodology was developed to quantify hyperoxidation of individual 2-Cys Prxs in cells.
Andrew G, Cox, Andree G, Pearson, Juliet M, Pullar, Thomas J, Jönsson, W Todd, Lowther, Christine C, Winterbourn, Mark B, Hampton   +6 more
openaire   +2 more sources

Comprehensive Characterization of Acer truncatum Leaf Extract: Identification of Systemic Metabolites and Effects on Performance, Antioxidant Status, and Intestinal Microbiota in Laying Hens

Animal Research and One Health, EarlyView.
Dietary A. truncatum leaf extract is absorbed and improves laying performance in aged hens by enhancing systemic antioxidant capacity and modulating the gut microbiota. ABSTRACT The demand for natural feed additives is considerably increasing in the antibiotic‐free feed era.
Kailong Qin, Jiantao Yang, Minglu Gao, Xiaozhao Tao, Xin Yang, Yanli Liu, Xiaojun Yang   +6 more
wiley   +1 more source

Peroxiredoxin 6 as a Unique Member of the Peroxiredoxin Family [PDF]

, 2019
The peroxiredoxin family was discovered approximately 30 years ago and is now recognized as one of the most important families of enzymes related to antioxidant defense and cellular signaling. Peroxiredoxin 6 shares the basic enzymatic functions that characterize this family, but also exhibits several unique and crucial activities.
openaire   +3 more sources

Localized redox relays as a privileged mode of cytoplasmic hydrogen peroxide signaling

Redox Biology, 2017
Hydrogen peroxide (H2O2) is a key signaling agent. Its best characterized signaling actions in mammalian cells involve the early oxidation of thiols in cytoplasmic phosphatases, kinases and transcription factors.
Rui D.M. Travasso, Fernando Sampaio dos Aidos, Anahita Bayani, Pedro Abranches, Armindo Salvador   +4 more
doaj   +1 more source

The antioxidant system of the respiratory tract. The intracellular antioxidant protection in the respiratory tract (part 6)

Zdorovʹe Rebenka, 2017
The literature review presents the current data about peroxiredoxin system in the functioning of the intracellular antioxidant protection in the respiratory tract. We present a model of the molecular structure of certain peroxiredoxins. The peroxiredoxin-
A.E. Abaturov, A.P. Volosovets, T.P. Borysova   +2 more
doaj   +1 more source