Results 141 to 150 of about 91,703 (262)

Urolithin A, a Diet‐Derived Gut Microbial Metabolite Against Pulmonary Hypertension Identified via Molecular Docking, Molecular Dynamics and Surface Plasmon Resonance

Food Safety and Health, EarlyView.
Urolithin A, a gut microbial metabolite, binds TNF to suppress proliferation, inflammation, and oxidative stress, offering a promising microbe‐derived therapeutic avenue for pulmonary hypertension. ABSTRACT Pulmonary hypertension (PH) is a complex and multifactorial disease that poses a significant clinical challenge.
Yujie Qu, Yinghua Huo, Yichen Wang, Yao Mu, Xue Yu, Leiyu Tian, Jian Guo, Xuezhi Yang, Yucai Chen   +8 more
wiley   +1 more source

Paeoniflorin Ameliorates Metabolic Dysfunction-Associated Steatotic Liver Disease by SYK/SH3BP2 Signaling Pathway

Research
Metabolic dysfunction-associated steatotic liver disease (MASLD) has emerged as the leading cause of chronic liver disease globally and constitutes an independent risk factor for cardiovascular disease and mortality. Paeoniflorin (PF), the primary active
Yuqing Liu, Jie Tao, Dongyu Tan, Feifan Zheng, Zhuoxuan Su, Jianfeng Yuan, Chunmei Zhu, Zhensen Zheng, Xiuteng Zhou, Duosheng Luo   +9 more
doaj   +1 more source

Cardiomyocyte peroxisome proliferator-activated receptor α prevents septic cardiomyopathy via improving mitochondrial function. [PDF]

Acta Pharmacol Sin, 2023
Zhu XX, Wang X, Jiao SY, Liu Y, Shi L, Xu Q, Wang JJ, Chen YE, Zhang Q, Song YT, Wei M, Yu BQ, Fielitz J, Gonzalez FJ, Du J, Qu AJ.   +15 more
europepmc   +1 more source

Leptin and peroxisome proliferator activated receptor alpha: understanding their contribution towards normalising the programmed phenotype in the peripheral tissues of IUGR offspring

, 2010
In a rat model of intrauterine growth restriction (IUGR) induced by maternal global undernutrition, adult offspring are obese with associated metabolic disturbances. These metabolic abnormalities are all augmented by feeding a high calorie postnatal diet
Garratt, Emma
core  

Peroxisome proliferator-activated receptor-α (PPARα) regulates wound healing and mitochondrial metabolism in the cornea. [PDF]

Proc Natl Acad Sci U S A, 2023
Liang W, Huang L, Whelchel A, Yuan T, Ma X, Cheng R, Takahashi Y, Karamichos D, Ma JX.   +8 more
europepmc   +1 more source

Mechanisms by which interleukin-4 suppresses inflammatory cytokine production by activated human monocytes

, 2011
Improving understanding of how inflammatory responses by monocytes and macrophages are regulated may aid in the development of more targeted therapies for chronic inflammatory disease.
Woodward, Eleanor
core  

Peroxisome Proliferator-Activated Receptor Agonists and Bladder Cancer: Lessons from Animal Studies

, 2014
This article reviews available animal studies on the possible link between the use of peroxisome proliferator-activated receptor (PPAR) agonists and bladder cancer, with further discussion on the possible implications to humans.
Tseng, Chin-Hsiao;Tseng, Farn-Hsuan, 曾慶孝   +1 more
core   +1 more source

Peroxisome proliferator-activated receptor α agonist induces mouse hepatomegaly through the spatial hepatocyte enlargement and proliferation. [PDF]

Acta Pharmacol Sin, 2023
Yang J, Yang X, Zhang YF, Tian JN, Fan SC, Gao Y, Li HL, Cai CH, Huang M, Bi HC.   +9 more
europepmc   +1 more source

Cross-species gene expression analysis of species specific differences in the preclinical assessment of pharmaceutical compounds

, 2014
Animals are frequently used as model systems for determination of safety and efficacy in pharmaceutical research and development. However, significant quantitative and qualitative differences exist between humans and the animal models used in research ...
Dzidzienyo, D, John Okyere, Sharma, L, Okyere, J, Oppon, E, Sharma Lav, Graham Ball, Ekow Oppon, Okyere John, Oppon Ekow, Daniel Dzidzienyo, Lav Sharma, Daniel Dzidzienyo (563466), Lav Sharma (563467), Ball, G, John Okyere (72708), Dzidzienyo Daniel, Ball Graham, Ekow Oppon (563465), Graham Ball (72613)   +19 more
core   +1 more source

Impaired autophagy contributes to the aggravated deterioration of osteoarthritis articular cartilage by peroxisome proliferator-activated receptor α deficiency, associated with decreased ERK and Akt activation. [PDF]

Eur J Med Res, 2023
Zhou Y, Li L, Chen X, Zhao Q, Qu N, Zhang B, Jin X, Xia C.   +7 more
europepmc   +1 more source