Results 331 to 340 of about 248,501 (390)

Peroxisome proliferator-activated receptors

Current Atherosclerosis Reports, 2002
An exciting and rapidly evolving area in vascular biology and atherosclerosis research over the past 3 years has been the establishment of peroxisome proliferator-activated receptor (PPAR) expression in the vascular and inflammatory cells, and the emerging picture of the roles these ligand-activated nuclear receptor/transcription factors might play in ...
Ouliana, Ziouzenkova, Stephane, Perrey, Niko, Marx, Daniel, Bacqueville, Jorge, Plutzky   +4 more
openaire   +2 more sources

Peroxisome proliferator-activated receptor agonists

Current Opinion in Chemical Biology, 1997
The peroxisome proliferator-activated receptors are a family of three ligand-activated transcription factors. Fibrate antihyperlipidemic drugs and thiazolidinedione antihyperglycemic drugs were recently identified as synthetic ligands for these receptors. In addition, certain unsaturated fatty acids and eicosanoids were shown to bind the receptors, and
T M, Willson, W, Wahli
openaire   +2 more sources

Peroxisome proliferator activated receptor agonists

2000
The peroxisome proliferator activated receptors (PPARs) represent a group of ligand-activated transcription factors that mediate the biological effects of various drugs, such as fibrates and thiazolidinediones. Three PPAR subtypes can be distinguished, alpha, beta and gamma, each of which has an unique pattern of expression among vertebrate tissues ...
S, Kersten, W, Wahli
openaire   +2 more sources

Peroxisome Proliferator Activated Receptors

2005
The metabolic activity of the liver plays a central role in coordinating the supply of energy to peripheral organs, in particular the brain. It is at the heart of an adaptive system, which allows survival at times of food deprivation and governs the storage of excess energy when plenty of food is available.
Raphaël Genolet, Liliane Michalik, Walter Wahli   +2 more
openaire   +1 more source

Peroxisome proliferator-activated receptor agonists and antagonists: a patent review (2014-present)

Expert Opinion on Therapeutic Patents, 2019
Introduction: Peroxisome proliferator-activated receptors (PPARs), PPARα, PPARδ, and PPARγ, play an important role in the regulation of various physiological processes, specifically lipid and energy metabolism and immunity.
I. Takada, M. Makishima
semanticscholar   +1 more source

Peroxisome Proliferator-Activated Receptors

Journal of Biological Research and Reviews
Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors that regulate key physiological processes, including lipid metabolism, glucose homeostasis, and inflammation. The three subtypes, PPAR-alpha, PPAR-beta/delta, and PPAR-gamma, have distinct roles and tissue distributions, making them promising targets for metabolic and ...
Robert Ringseis, Klaus Eder
openaire   +2 more sources

Peroxisome proliferator-activated receptors and angiogenesis

Nutrition, Metabolism and Cardiovascular Diseases, 2009
The peroxisome proliferator-activated receptors (PPARs) are a group of three nuclear receptor isoforms, PPARalpha, PPARgamma and PPARdelta, encoded by different genes, and they form a subfamily of the nuclear receptor superfamily. The clinical interest in PPARs originates with fibrates and thiazolidinediones, which, respectively, act on PPARalpha and ...
F, Biscetti, G, Straface, D, Pitocco, F, Zaccardi, G, Ghirlanda, A, Flex   +5 more
openaire   +2 more sources

Peroxisome proliferator-activated receptors and inflammation

Pharmacology & Therapeutics, 2006
Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear hormone receptors family. PPARs are a family of 3 ligand-activated transcription factors: PPARalpha (NR1C1), PPARbeta/delta (NUC1; NR1C2), and PPARgamma (NR1C3). PPARalpha, -beta/delta, and -gamma are encoded by different genes but show substantial amino acid similarity ...
Leonardo A, Moraes, Laura, Piqueras, David, Bishop-Bailey   +2 more
openaire   +2 more sources

Peroxisome Proliferator-Activated Receptors and Atherosclerosis

Angiology, 2011
The peroxisome proliferator-activated receptors (PPARs) represent the family of 3 nuclear receptor isoforms-PPARα, -γ, and -δ/β, which are encoded by different genes. As lipid sensors, they are primarily involved in regulation of lipid metabolism and subsequently in inflammation and atherosclerosis.
Soskić, Sanja S, Dobutović, Branislava D, Sudar, Emina M, Obradović, Milan M, Nikolić, Dragana M, Zarić, Bozidarka L, Stojanović, Srdan D, Stokić, Edita J, Mikhailidis, Dimitri P, Isenović, Esma R   +9 more
openaire   +5 more sources

Regulation of Peroxisome Proliferator-Activated Receptors

1998
Publisher Summary This chapter describes the selected aspects of the current understanding about the workings of peroxisome proliferator-activated receptors (PPARs) and how they are regulated. The members of the nuclear receptor family regulate different aspects of development, differentiation, growth, homeostasis, and metabolism in the cell.
H N, Sørensen, E, Treuter, J A, Gustafsson   +2 more
openaire   +2 more sources