Results 261 to 270 of about 95,453 (303)

Peroxisome proliferator-activated receptor gamma: promising target in glioblastoma

Panminerva Medica, 2018
Glioblastoma, also known as glioblastoma multiforme, is the most common and worldwide-spread cancer that begins within the brain. Glioblastomas represent 15% of brain tumors. The most common length of survival following diagnosis is 12 to 14 months with less than 3% to 5% of people surviving longer than five years.
Gaurav, Gupta, Gautam, Singhvi, Dinesh K, Chellappan, Sanjay, Sharma, Anurag, Mishra, Rajiv, Dahiya, Terezinha, de Jesus Andreoli Pinto, Kamal, Dua   +7 more
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Peroxisome proliferator-activated receptor gamma agonists as neuroprotective agents

Drug News & Perspectives, 2010
Peroxisome proliferator-activated receptor gamma (PPARgamma) has already been considered as an attractive therapeutic target for the treatment of metabolic disorders. Recently, PPARgamma agonists were shown to effectively attenuate oxidative stress, inflammation and apoptosis in the central nervous system.
Ravinder K, Kaundal, Shyam S, Sharma
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The pleiotropic functions of peroxisome proliferator-activated receptor γ

Journal of Molecular Medicine, 2000
Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors, initially described as molecular targets for synthetic compounds that induce peroxisome proliferation. PPARgamma is the best characterized of the PPARs. The heterodimer of PPARgamma with the retinoid X receptor (RXR) plays a crucial role in adipogenesis and insulin ...
Debril, Marie-Bernard, Renaud, Jean-Paul, Fajas, Lluis, Auwerx, Johan   +3 more
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Peroxisome proliferator-activated receptor γ and atherosclerosis

Current Hypertension Reports, 2002
Within the past couple of years, peroxisome proliferator-activated receptor gamma (PPARgamma), a nuclear transcription factor expressed in vascular cells, has received growing interest in vascular biology and atherosclerosis research. Initially, PPARgamma was identified as a regulator of gene expression in lipid metabolism and adipogenesis, but recent ...
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Diclofenac Antagonizes Peroxisome Proliferator-Activated Receptor-γ Signaling

Molecular Pharmacology, 2002
Although nonsteroidal anti-inflammatory drugs (NSAIDs) are used as cancer chemopreventative agents, their mechanism is unclear because NSAIDs have cyclooxygenase-independent actions. We investigated an alternative target for NSAIDs, peroxisome proliferator-activated receptor-gamma (PPARgamma), activation of which decreases cancer cell proliferation ...
Adamson, Douglas J. A., Frew, David, Tatoud, Roger, Wolf, C. Roland, Palmer, Colin N. A.   +4 more
openaire   +3 more sources

Peroxisome proliferator-activated receptor γ in malignant diseases

Critical Reviews in Oncology/Hematology, 2006
Peroxisome proliferator-activated receptor gamma (PPAR-gamma) belongs to the family of nuclear hormone receptors (NHRs) and is a ligand-activated transcription factor. There are four mRNAs, PPAR-gamma1, PPAR-gamma2, PPAR-gamma3 and PPAR-gamma4, which encode two proteins, PPAR-gamma1and PPAR-gamma2. PPAR-gamma consists of five or six structural regions (
Tingting, Wang, Jian, Xu, Xiaofei, Yu, Renchi, Yang, Zhong Chao, Han   +4 more
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Peroxisome Proliferator–Activated Receptor γ and Metabolic Disease

Annual Review of Biochemistry, 2001
▪ Abstract  The nuclear peroxisome proliferator–activated receptor γ (PPARγ) is a transcription factor that is activated by polyunsaturated fatty acids and their metabolites and is essential for fat cell formation. Although obesity is a strong risk factor for type 2 diabetes mellitus and other metabolic diseases, potent PPARγ activators such as the ...
T M, Willson, M H, Lambert, S A, Kliewer
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Peroxisome proliferator activated receptor (PPAR)-gamma concentrations in childhood obesity

Scandinavian Journal of Clinical and Laboratory Investigation, 2013
Peroxisome proliferator-activated receptors (PPARs) are nuclear proteins that regulate transcriptional responses to peroxisome proliferators. There has been limited research concerned with the childhood expression of these receptors. In this study, we aimed to evaluate PPAR-gamma (PPAR-γ) concentrations and their relationship to body mass index (BMI ...
Nesibe, Akyürek, Zehra, Aycan, Semra, Çetinkaya, Ömer, Akyürek, Sebahat, Yilmaz Ağladioğlu, Ülker, Ertan   +5 more
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Peroxisome Proliferator-Activated Receptor Gamma (PPAR-γ) and Neurodegenerative Disorders

Molecular Neurobiology, 2012
As the growth of the aging population continues to accelerate globally, increased prevalence of neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), and stroke, has generated substantial public concern. Unfortunately, despite of discoveries of common factors underlying these diseases, few drugs are available to ...
Yu-Chang, Chen, Jui-Sheng, Wu, Hsin-Da, Tsai, Chien-Yu, Huang, Jin-Jer, Chen, Grace Y, Sun, Teng-Nan, Lin   +6 more
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Peroxisome proliferator-activated receptor gamma inhibits hepatic fibrosis in rats

Hepatobiliary & Pancreatic Diseases International, 2011
Hepatic fibrosis is a necessary step in the development of hepatic cirrhosis. In this study we used lentiviral vector-mediated transfection technology to evaluate the effect of peroxisome proliferator-activated receptor gamma (PPAR-gamma) on rat hepatic fibrosis.Hepatic fibrosis in rats was induced by CCl4 for 2 weeks (early fibrosis) and 8 weeks ...
Zheng, Wang, Jia-Peng, Xu, Yong-Chao, Zheng, Wei, Chen, Yong-Wei, Sun, Zhi-Yong, Wu, Meng, Luo   +6 more
openaire   +2 more sources