Results 141 to 150 of about 34,934 (252)

Inconsistent Transcriptomic Responses to Hexabromocyclododecane in Japanese Quail: A Comparative Analysis of Results From Four Different Study Designs

Environmental Toxicology and Chemistry, EarlyView.
Abstract Efforts to use transcriptomics for toxicity testing have classically relied on the assumption that chemicals consistently produce characteristic transcriptomic signatures that are reflective of their mechanism of action. However, the degree to which transcriptomic responses are conserved across different test methodologies has seldom been ...
Paul Béziers, Elena Legrand, Emily Boulanger, Niladri Basu, Jessica D. Ewald, Paula Henry, Markus Hecker, Jianguo Xia, Natalie Karouna‐Renier, Doug Crump, Jessica Head   +10 more
wiley   +1 more source

Organelle Crosstalk and Metabolic Reprogramming in Idiopathic Pulmonary Fibrosis: Mechanisms and Therapeutic Implications. [PDF]

Cell Biochem Funct
Zhang Y, Teng L, Gong L, Fu Y, Qian M.
europepmc   +1 more source

Rewiring nutrition: Chemical insights into the physiological and microbiological roles of food's microconstituents

Food Biomacromolecules, EarlyView.
Bidirectional interactions between food‐derived sensory compounds, gut sensing and microbiota, host physiological feedback, and metabolite production within the food matrix collectively shape sensory perception, microbial dynamics, and metabolic health.
Mohammad Nazrul Islam Bhuiyan
wiley   +1 more source

Peroxisomal Degradation Correlates with the Progression of Kidney Injury in a UUO Mouse Model. [PDF]

Biology (Basel)
Kim J, Kim H, Chhetri A, Manandhar L, Jang G, Park C, Park R.   +6 more
europepmc   +1 more source

Anti‐Inflammatory Effects of Punicic Acid and Its Molecular Mechanisms in RAW264.7 Cells and Zebrafish

Food Safety and Health, EarlyView.
Punicic acid (PA) was enriched and purified from PSO by molecular distillation with significant anti‐inflammatory activity to RAW264.7 cells, as well as to zebrafish. Anti‐inflammatory mechanism involved regulating NF‐κB and MAPK signaling pathways. ABSTRACT Punicic acid (PA) is the main fatty acid in pomegranate seeds, which shows multiple biological ...
Mengqi Zhang, Caiyun Feng, Mengyao Zhu, Xu Guo, Yingying Chen, Wenwen Hu, Fei Dong, Jinyue Sun, Chao Liu   +8 more
wiley   +1 more source

Peroxisomal Lipid Metabolism as a Therapeutic Target in Leukemia. [PDF]

Mol Nutr Food Res
Parfenova EN, Spagnuolo PA.
europepmc   +1 more source

LXRα and PPARα Mediated Hepatic Lipid Metabolic Disruption Induced by the UV Filter EHMC in 2D and 3D HepaRG Cell Models

Food Safety and Health, EarlyView.
Dietary UV filter EHMC induces hepatic steatosis in HepaRG cells at noncytotoxic concentrations. Mechanistically, EHMC binds nuclear receptors (LXRα, PPARα), upregulating SREBP‐1 to accelerate fatty acid synthesis. These findings highlight the potential metabolic toxicity of widespread EHMC exposure through food sources.
Shanglin Yang, Na Li, Yingnan Han, Mei Ma   +3 more
wiley   +1 more source

Gut Microbiota Modulation and Functional Effects of Edible and Medicinal Fungi: Sanghuangporus vaninii as a Case Study

Gut Medicine, EarlyView.
ABSTRACT Edible and medicinal fungi exert diverse biological effects, including immunomodulatory, antitumour, and anti‐inflammatory activities, as well as the amelioration of metabolic disorders. The relationship between these effects and the gut microbiota is attracting increasing attention.
Meng Teng, Wenqi Li, Di Wang, Lanzhou Li
wiley   +1 more source

Lipid Metabolism in Regulatory T Cells in Health and Disease. [PDF]

J Inflamm Res
Sato Y.
europepmc   +1 more source

Peroxisome calcium uptake is dependent on ER-peroxisome membrane contact. [PDF]

Cell Mol Life Sci
Kalinowski J, Hartmann Y, Lütkemeyer A, Thoms S.   +3 more
europepmc   +1 more source