Results 311 to 320 of about 125,831 (393)

Dupilumab Dampens Mucosal Type 2 Response During Acetylsalicylic Acid Challenge in N‐ERD Patients

Clinical &Experimental Allergy, EarlyView.
Dupilumab therapy reduced elevated type 2 cytokine responses post‐ASA provocation in N‐ERD patients, independent of ASA tolerance, and revealed novel mechanistic insights by modulating acute type 2 immunity. Transcriptomic analysis showed concurrent downregulation of lipid and peroxisome pathways during ASA challenge in N‐ERD patients after 24 weeks of
Julia Eckl‐Dorna, Christina Morgenstern, Katharina Poglitsch, Tamara Arnoldner, Katharina Gangl, Tina J. Bartosik, Nicholas J. Campion, Aldine Tu, Victoria Stanek, Sven Schneider, Christine Bangert   +10 more
wiley   +1 more source

Msp1 and Pex19-Pex3 cooperate to achieve correct localization of Pex15 to peroxisomes. [PDF]

FEBS J
Matsumoto S, Kogure Y, Ono S, Numata T, Endo T.   +4 more
europepmc   +1 more source

Reversal of MPPa‐PDT Resistance in Osteosarcoma by Targeting ROCK2‐Mediated Autophagy

Cell Proliferation, EarlyView.
ROCK2 competes with MST1 to bind to the aa 28‐198 region of SAV1 and then regulates the Hippo pathway to affect autophagy, resulting in the resistance of OS to MPPa‐PDT. Targeted inhibition of ROCK2 by screening for J059‐0149 increases the sensitivity of osteosarcoma to MPPa‐PDT. ABSTRACT Osteosarcoma (OS) is a primary bone tumour that occurs mostly in
Xuan Yi, Xueqiang Deng, Jianyong Deng, Chen Li, Hong Peng, Yunyan Du, Qing Li, Xiaohua Yan, Xin Hu, Yan Zheng, Shenliang Chen, Ting Xiong, Debin Xu, Leifeng Chen, Liang Hao   +14 more
wiley   +1 more source

Identifying and characterizing a missing peroxin-PEX8-in Arabidopsis thaliana. [PDF]

Plant Cell
Buck GC, Weeks AD, Ordner NE, Bartel B.
europepmc   +1 more source

Pioglitazone Ameliorates Mitochondrial Oxidative Stress and Inflammation via AMPK‐Dependent Inhibition of Mitochondrial Fission in Leigh Syndrome

Cell Proliferation, EarlyView.
Pioglitazone suppresses mitochondrial excessive ROS generation and COX‐2 level through inhibition of Drp‐1 mediated mitochondrial fission in an AMPK‐dependent manner in LS. ABSTRACT Loss of function mutations of NDUFS4 resulted in Leigh syndrome, which is a progressive neurodegenerative disease and characterized by mitochondrial oxidative stress ...
Jie Luo, Ling Chen, Xiaoxian Zhang, Qiang Su, Xiaoya Zhou, Qizhou Lian   +5 more
wiley   +1 more source

Saccharomyces cerevisiae malate dehydrogenase Mdh1p lacking mitochondrial targeting signal can be re-localized to peroxisomes. [PDF]

Biol Open
Chan C, Sirinonthanawech N, Sato BK, Wilhelm JE, Noree C.   +4 more
europepmc   +1 more source

Atopic Dermatitis (AD) Related Cord Blood DNA Methylation Patterns Are Linked to Maternal AD

Allergy, EarlyView.
Laura Matzner, Johanna Denkena, Marey Messingschlager, Anke Seegebarth, Rosa Engelhardt, Zhuoxin Peng, Parastoo Kheiroddin, Sebastian D. Mackowiak, Hermann Brenner, Dietrich Rothenbacher, Naveed Ishaque, Michael Kabesch, Roland Eils, Jon Genuneit, Saskia Trump, Irina Lehmann   +15 more
wiley   +1 more source

Gestational Melatonin Supplementation Attenuates Maternal Sleep Deprivation‐Induced Steatohepatitis Susceptibility in Offspring

Cell Proliferation, EarlyView.
Maternal SD during pregnancy enhances the development of diet‐induced NASH in adult offspring of both sexes through an NR4A3‐dependent mechanism, characterised by heightened inflammation and increased apoptosis. Maternal melatonin supplementation effectively alleviates this increased susceptibility to NASH in offspring.
Fei Guo, Zexin Yang, Junsen She, Chen Fang, Yizhi Hu, Hefeng Huang, Ling Gao   +6 more
wiley   +1 more source

FATP2 at the crossroads of fatty acid transport, lipotoxicity, and complex disease. [PDF]

J Clin Invest
Black PN, DiRusso CC.
europepmc   +1 more source

Fenofibrate (peroxisome proliferator-activated receptor alpha agonist) modulates the renin-angiotensin system in the heart of mice fed with a high-fat diet

, 2012
Thiago da Silva Torres
openalex   +1 more source