Results 181 to 190 of about 76,980 (312)

A comparison between the antioxidant and peroxynitrite-scavenging functions of the vitamin E metabolites alpha- and gamma-carboxyethyl-6-hydroxychromans

, 2004
Francesco Galli, Marta Piroddi, Anna Iannone, Pagliarani, Aldo Tomasi, Floridi   +5 more
openalex   +2 more sources

Design and Synthesis of Novel Purine Analogues as Potential IL‐1β Inhibitors Targeting Vascular Inflammation

Chemistry &Biodiversity, Volume 23, Issue 1, January 2026.
Initial screening of the synthesized compounds revealed that compounds MK175 and MK169 inhibited LPS‐induced IL‐1β release in human aortic smooth muscle cells. ABSTRACT Proinflammatory cytokine interleukin (IL)‐1β is a key mediator of the inflammatory response in atherosclerosis.
Dimitra T. Pournara, Theano Fotopoulou, Geena Paramel, Madelene Lindkvist, Magnus Grenegård, Karin Fransén, Maria Koufaki   +6 more
wiley   +1 more source

Photoelectrochemical Coupling of Waste‐Nitrogen Oxidation Reactions with Hydrogen Evolution for Sustainable Energy Conversion

ChemSusChem, Volume 19, Issue 1, January 2026.
Photoelectrochemical (PEC) cells utilize alternative oxidation pathways, allowing for the production of high‐value products, including N2, CO2, and nitrates. Key advantages include innovative catalyst design, improved charge separation, reduced energy input, and economic viability.
Maheswari Arunachalam, Jyoti Ganapati Badiger, Suzan Abdelfattah Sayed, Soon Hyung Kang   +3 more
wiley   +1 more source

Targeting neutrophil‐driven immunosuppression: A strategy to overcome immune checkpoint inhibitor resistance

Clinical and Translational Medicine, Volume 16, Issue 1, January 2026.
TANs drive ICI resistance via antitumour immune remodelling, angiogenesis promotion, and elevation of tumour mutation burden Neutrophil biomarkers (e.g., NLR, TAN abundance) show strong predictive value for ICI response and prognosis. Targeting TAN recruitment, polarization, function and NETosis represents a promising strategy to overcome ICI ...
Ying Ning, Ke Lei, Xinyan Gao, Yan Kong, Yuping Shan, Tian Tian, Zhumei Cui, He Ren   +7 more
wiley   +1 more source

Toxic Tear Gas 2‐Chloroacetophenone (CN) Forms Adducts With Endogenous Plasma Thiols In Vitro Valuable as Biomarkers of Exposure

Drug Testing and Analysis, Volume 18, Issue 1, Page 74-84, January 2026.
Incubation of human plasma with the tear gas 2‐chloroacetophenone (CN) led to the formation of acetophenone (AcPhen)‐adducts with the small plasma thiols glutathione, homocysteine, and cysteine persulfide. The AcPhen‐adducts were either bound to an organic thiol‐group or to an organic persulfide. The adducts were detected with a mass spectrometry‐based
Paula Helena Sieber, Dirk Steinritz, Franz Worek, Harald John   +3 more
wiley   +1 more source

Serum Uric Acid as a Mediator of Insulin Resistance: Molecular Mechanisms and Metabolic Pathways

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 1, January 2026.
Elevated SUA can lead to oxidative stress, endothelial dysfunction, inflammation and impaired function of adipocytes—all of which collectively impede insulin receptor activity and downstream signalling. Key pathways involved include activation of the NLRP3 inflammasome, suppression of AMPK and induction of mitochondrial dysfunction.
Nurshad Ali
wiley   +1 more source

Mitochondrial superoxide dismutase controls metabolic plasticity in pancreatic cancer. [PDF]

Cell Commun Signal
Ramasubramanian S, Öllinger R, Eberhagen C, Zischka H, Schmid RM, Einwächter H.   +5 more
europepmc   +1 more source

Hypoxia Potentiates Nitric Oxide-mediated Apoptosis in Endothelial Cells via Peroxynitrite-induced Activation of Mitochondria-dependent and -independent Pathways [PDF]

, 2004
Geoffrey Walford, Rose‐Laure Moussignac, Anne Ward Scribner, Joseph Loscalzo, Jane A. Leopold   +4 more
openalex   +1 more source

Protective Roles of Prebiotics and Probiotics Against Environmental Pollutant‐Induced Toxicities: A Systematic Review of Animal Studies

Molecular Nutrition &Food Research, Volume 70, Issue 1, January 2026.
Pollutant‐induced epithelial damage also leads to a cascade of harmful effects, including reduced mucus secretion, decreased luminal pH, and enhanced absorption of toxins. These changes contribute to oxidative stress (↑ malondialdehyde (MDA); ↓ superoxide dismutase (SOD), catalase (CAT), glutathione (GSH), glutathione peroxidase (GPx), and heightened ...
Meysam Zarezadeh Ph.D., Ahmad Saedisomeolia, Mahsa Mahmoudinezhad, Michele M. Iskandar, Fang Lu, Stan Kubow   +5 more
wiley   +1 more source

Mechanism of Action and Anti-Inflammatory Activity of Pestalotioquinol A, a Fungus-Derived Cytoprotective Compound. [PDF]

ACS Omega
Tsurukawa Y, Katayama Y, Kanno K, Sato K, Suzuki Y, Murakami H, Takeda S, Sakaue M, Sogawa K, Shinoda Y, Nagane M, Aihara N, Kamisuki S.   +12 more
europepmc   +1 more source