Results 51 to 60 of about 84,481 (342)
Cyclic Hydroxylamines as Monitors of Peroxynitrite and Superoxide-Revisited
Antioxidants, 2021 There is a considerable need for methods that allow quantitative determination in vitro and in vivo of transient oxidative species such as peroxynitrite (ONOOH/ONOO−) and superoxide (HO2•/O2•−).
Uri Samuni, Amram Samuni, Sara Goldstein
doaj +1 more source
Adiponectin protects against paraquat-induced lung injury by attenuating oxidative/nitrative stress. [PDF]
, 2014 The specific mechanisms underlying paraquat (PQ)-induced lung injury remain unknown, which limits understanding of its cytotoxic potential. Although oxidative stress has been established as an important mechanism underlying PQ toxicity, multiple ...
Cao, Yu +9 more
core +2 more sources
Reaction of Astaxanthin with Peroxynitrite [PDF]
Bioscience, Biotechnology, and Biochemistry, 2008 The in vitro reactivities of astaxanthin toward peroxynitrite were investigated and the reaction products after scavenging with peroxynitrite were analyzed in order to determine the complete mechanism of this reaction. A series of carotenoids, 13-apo-astaxanthinone (1), 12'-apo-15'-nitroastaxanthinal (2), 12'-apo-astaxanthinal (3), 10'-apo ...
Aditya Kulkarni +5 more
openaire +3 more sources
Communicative Nanomotors Reprogram Cancer Cell Death via Pyroptosis
Angewandte Chemie, EarlyView.Communicative nanomotors respond to elevated ROS in the tumor microenvironment, enabling active communication and selective mitochondrial targeting through non‐covalent surface engineering. Their precise interaction with cells induces mitochondrial damage, cytochrome c release, and pyroptotic cell death, while chemotactic motility ensures deeper tumor ...
Mingchen Sun +3 more
wiley +2 more sources
T-cadherin deficiency increases vascular vulnerability in T2DM through impaired NO bioactivity. [PDF]
, 2017 BACKGROUND: Endothelial dysfunction plays a critical role in the development of type 2 diabetes (T2DM). T-cadherin (T-cad) has gained recognition as a regulator of endothelial cell (EC) function.
Ambrosio, Anastasia +7 more
core +2 more sources
Angewandte Chemie, EarlyView.When cellular iron is low, bacterioferritin (Bfr) releases its stored iron through a reductive process dependent on the [2Fe–2S] ferredoxin Bfd. Why accessing stored iron should depend on an iron‐requiring protein when iron is scarce is unclear. Here, we show that the Bfd [2Fe–2S] cluster is sensitive to oxidative stress, suggesting that it may act as ...
Justin M. Bradley +4 more
wiley +2 more sources
Linoleic acid-induced mitochondrial Ca(2+) efflux causes peroxynitrite generation and protein nitrotyrosylation. [PDF]
PLoS ONE, 2009 It is well known that excessive non-esterified fatty acids in diabetes contribute to the pathogenesis of renal complications although the mechanism remains elusive.
Hong-Mei Zhang +3 more
doaj +1 more source
Moderate Champagne consumption promotes an acute improvement in acute endothelial-independent vascular function in healthy human volunteers [PDF]
, 2009 Epidemiological studies have suggested an inverse correlation between red wine consumption and the incidence of CVD. However, Champagne wine has not been fully investigated for its cardioprotective potential. In order to assess whether acute and moderate
Christelle Sellier +15 more
core +2 more sources
Supersulfide biology and translational medicine for disease control
British Journal of Pharmacology, EarlyView., 2023 Abstract For decades, the major focus of redox biology has been oxygen, the most abundant element on Earth. Molecular oxygen functions as the final electron acceptor in the mitochondrial respiratory chain, contributing to energy production in aerobic organisms. In addition, oxygen‐derived reactive oxygen species including hydrogen peroxide and nitrogen
Uladzimir Barayeu +5 more
wiley +1 more source
Angewandte Chemie, EarlyView.We have engineered the heme biosynthetic pathway in E. coli to develop an efficient cofactor supplementation system for hemoproteins. Through the incorporation of the heterogeneous C4 pathway, the engineered cells significantly increase the expression levels of active holohemoproteins and enhance the efficiency of whole‐cell and lysate‐based ...
Shunsuke Kato +6 more
wiley +2 more sources