Results 51 to 60 of about 36,943 (245)

Targeting signaling pathways in neurodegenerative diseases: Quercetin's cellular and molecular mechanisms for neuroprotection

Animal Models and Experimental Medicine, EarlyView.
Quercetin regulates signaling pathways in neurodegenerative diseases, including NF‐κB, sirtuins, and PI3K/Akt. Studies show quercetin improves symptoms and pathology in neurodegenerative models. The study aims to incorporate laboratory research into practical medical treatment, focusing on quercetin's neuroprotective effects and optimal dosage ...
Md. Rezaul Islam, Md. Ibrahim Khalil Al‐Imran, Mehrukh Zehravi, Sherouk Hussein Sweilam, Mohammad Rakib Mortuza, Jeetendra Kumar Gupta, Thukani Sathanantham Shanmugarajan, Kadirvel Devi, Tanuja Tummala, Mohammed Ali Alshehri, Kalirajan Rajagopal, Mohammed Asiri, Irfan Ahmad, Talha Bin Emran   +13 more
wiley   +1 more source

ISOMERIZATION AND DISSOCIATION OF THE PEROXYNITRITE ION FORMED BY DISSOLVING CRYSTALLINE POTASSIUM NITRATE IRRADIATED WITH 253.7 NMLIGHT

Вестник Кемеровского государственного университета, 2015
Photoinduced peroxynitrite in potassium nitrate is stable after dissolution in highly alkaline solutions (pH > 13). Increasing the pH of the solution from 10.5 to 14 increases peroxynitrite stability.
E. P. Dyagileva, M. B. Miklin
doaj  

Peroxynitrite Activated Drug Conjugate Systems Based on a Coumarin Scaffold Toward the Application of Theranostics

Frontiers in Chemistry, 2019
Two novel drug-conjugates based on a “coumarin linker” have been designed for the synergic release of a therapeutic agent and fluorescent probe for the potential application of theranostics.
Maria L. Odyniec, Hai-Hao Han, Jordan E. Gardiner, Adam C. Sedgwick, Xiao-Peng He, Steven D. Bull, Tony D. James   +6 more
doaj   +1 more source

Leishmanicidal activity of peroxynitrite

Redox Report, 1995
Nitric oxide reacts with superoxide to produce peroxynitrite which has been reported to be highly microbicidal to Trypanosoma cruzi in phosphate buffer but ineffective against Leishmania major in culture medium. This contradiction and the potential importance of peroxynitrite as a cytotoxic effector molecule of both macrophages and neutrophils led us ...
Ohara Augusto, Jolie K Kwee, Reynaldo M. Gatti, Selma Giorgio   +3 more
openaire   +3 more sources

Conjugated polymers as photocatalysts for hydrogen therapy

BMEMat, EarlyView.
Conjugated polymers, including linear polymers and crosslinked conjugated materials, are promising photocatalysts for hydrogen evolution due to their excellent optical properties. Hydrogen therapy based on photocatalytic hydrogen evolution presented significant effects in the fields of anti‐inflammatory, free radical scavenging, and cancer treatment ...
Feixue Mi, Ningjing Zhao, Lingyue Jin, Ziyi Zhang, Xinyu Wang, Xiaofeng Fang, Wenting Li, Zhao Liu, Peng Shu, Xuanjun Zhang, Changfeng Wu   +10 more
wiley   +1 more source

Direct oxidation of boronates by peroxynitrite: Mechanism and implications in fluorescence imaging of peroxynitrite [PDF]

Free Radical Biology and Medicine, 2009
In this study, we show that boronates, a class of synthetic organic compounds, react rapidly and stoichiometrically with peroxynitrite (ONOO(-)) to form stable hydroxy derivatives as major products. Using a stopped-flow kinetic technique, we measured the second-order rate constants for the reaction with ONOO(-), hypochlorous acid (HOCl), and hydrogen ...
Marcos Lopez, Adam Sikora, Balaraman Kalyanaraman, Jacek Zielonka, Joy Joseph   +4 more
openaire   +3 more sources

X‐ray controlled release strategy in cancer therapy

BMEMat, EarlyView.
A comprehensive review on the design principles and current strategies of X‐ray stimulated release systems in cancer therapy, focusing on the X‐ray responsive functional groups and materials as well as discussing the advantages and current challenges of X‐ray controlled release systems in cancer therapy.
Yiling Ruan, Hongxiang Huang, Huihui Liu, Jinglang Gong, Changjun Li, Xiaolian Sun   +5 more
wiley   +1 more source

Ciprofloxacin but not amoxicillin significantly elevated serum peroxynitrite level in patients with enteric (typhoid fever): In vitro study

مجلة كلية الطب, 2006
Peroxynitrite is one intermediate of reactive nitrogen species with bactericidal and cylotoxic effects. Fluoroquinolones. drugs used for salmonella infections, are interacted v\ith nitrogen species and their baeterieida effect is influenced by these ...
Marwan S.M. Al-Nimer, Nada A. Abd al-Husain Al-Jrah   +1 more
doaj  

Effects of plant- and animal-based-protein meals for a day on serum nitric oxide and peroxynitrite levels in healthy young men

Endocrine Journal
Plant-based diets that replace animal-based proteins with plant-based proteins have received increased attention for cardiovascular protection. Nitric oxide (NO) plays an essential role in the maintenance of endothelial function.
Tomoko Kaneko, Masaki Yoshioka, Futo Kawahara, Natsumi Nishitani, Shoya Mori, Jiyeon Park, Takashi Tarumi, Keisei Kosaki, Seiji Maeda   +8 more
doaj   +1 more source

Anthocyanin Extracts From 11 Superfruits Mitigate Oxidative Stress and Inflammatory Damage in HK‐2 Cells Induced by Cadmium Exposure

Food Frontiers, EarlyView.
ABSTRACT Cadmium (Cd) pollution has emerged as an escalating threat to human health, with its induced kidney toxicity being closely linked to oxidative stress and inflammation. In this study, we extracted and analyzed primary anthocyanins from 11 superfruits using UPLC‐Triple‐TOF/MS and evaluated their antioxidant capacity through DPPH, ABTS, FRAP, and
Jiaojiao Liang, Yunyi Chen, Manxi Wu, Jiebiao Chen, Cui Sun, Jinping Cao, Yue Wang, Chongde Sun   +7 more
wiley   +1 more source