Results 81 to 90 of about 84,481 (342)
Advanced Science, EarlyView.The novel microneedle patches (MN@CTB) are fabricated by integrating CTB nanozymes into HAMA and PVA solution based on a photo‐crosslinking reaction. The MN@CTB microneedle patches present an excellent photothermal effect and NIR‐stimulated release of NO, which is advantageous for the elimination of MRS.
Wei Qian +13 more
wiley +1 more source
FEBS Open Bio, 2018 Nitrobindins (Nbs), constituting a heme‐protein family spanning from bacteria to Homo sapiens, display an all‐β‐barrel structural organization. Human Nb has been described as a domain of the nuclear protein named THAP4, whose physiological function is ...
Giovanna De Simone +3 more
doaj +1 more source
Peroxynitrate formed during a transient episode of brain ischemia increases endothelium-derived hyperpolarization-type dilations in thromboxane/prostaglandin receptor stimulated rat cerebral arteries [PDF]
, 2016 Aim Increased thromboxane A2 and peroxynitrite are hallmarks of cerebral ischemia/reperfusion (I/R). Stimulation of thromboxane/prostaglandin receptors (TP) attenuates endothelium-derived hyperpolarization (EDH).
Balavoine +50 more
core +2 more sources
Chemical Science, 2017 A peroxynitrite-specific two-photon fluorescent probe was developed for revealing drug-induced hepatotoxicity using peroxynitrite as a biomarker.
Yong Li +7 more
semanticscholar +1 more source
Superoxide Radical Dismutation as New Therapeutic Strategy in Parkinson’s Disease [PDF]
, 2017 open4siAging is the biggest risk factor for developing many neurodegenerative disorders, including idiopathic Parkinson's disease (PD). PD is still an incurable disorder and the available medications are mainly directed to the treatment of symptoms in ...
core +1 more source
Frontiers in Chemistry, 2019 Two novel drug-conjugates based on a “coumarin linker” have been designed for the synergic release of a therapeutic agent and fluorescent probe for the potential application of theranostics.
Maria L. Odyniec +6 more
doaj +1 more source
Вестник Кемеровского государственного университета, 2015 Photoinduced peroxynitrite in potassium nitrate is stable after dissolution in highly alkaline solutions (pH > 13). Increasing the pH of the solution from 10.5 to 14 increases peroxynitrite stability.
E. P. Dyagileva, M. B. Miklin
doaj
Leishmanicidal activity of peroxynitrite
Redox Report, 1995 Nitric oxide reacts with superoxide to produce peroxynitrite which has been reported to be highly microbicidal to Trypanosoma cruzi in phosphate buffer but ineffective against Leishmania major in culture medium. This contradiction and the potential importance of peroxynitrite as a cytotoxic effector molecule of both macrophages and neutrophils led us ...
Ohara Augusto +3 more
openaire +3 more sources
Pharmacology and clinical drug candidates in redox medicine [PDF]
, 2015 SIGNIFICANCE Oxidative stress is suggested to be a disease mechanism common to a wide range of disorders affecting human health. However, so far, the pharmacotherapeutic exploitation of this, for example, based on chemical scavenging of pro-oxidant ...
Casas, Ana I +11 more
core +2 more sources
Direct oxidation of boronates by peroxynitrite: Mechanism and implications in fluorescence imaging of peroxynitrite [PDF]
Free Radical Biology and Medicine, 2009 In this study, we show that boronates, a class of synthetic organic compounds, react rapidly and stoichiometrically with peroxynitrite (ONOO(-)) to form stable hydroxy derivatives as major products. Using a stopped-flow kinetic technique, we measured the second-order rate constants for the reaction with ONOO(-), hypochlorous acid (HOCl), and hydrogen ...
Marcos Lopez +4 more
openaire +3 more sources