Results 1 to 10 of about 1,721 (149)

Peroxynitrous acid (ONOOH) modifies the structure of anastellin and influences its capacity to polymerize fibronectin [PDF]

Redox Biology, 2020
Anastellin (AN), a fragment of the first type III module in fibronectin (FN), initiates formation of superfibronectin, a polymer which resembles the native cell-derived fibrillar FN found in the extracellular matrix of many tissues, but which displays ...
Jianfei He, Eva Ramos Becares, Peter Waaben Thulstrup, Luke F. Gamon, Jannik Nedergaard Pedersen, Daniel Otzen, Pontus Gourdon, Michael J. Davies, Per Hägglund   +8 more
doaj   +4 more sources

Peroxynitrous Acid Generated In Situ from Acidified H₂O₂ and NaNO₂. A Suitable Novel Antimicrobial Agent? [PDF]

Antibiotics, 2021
Peroxynitrite (ONOO−) and peroxynitrous acid (ONOOH) are known as short acting reactive species with nitrating and oxidative properties, which are associated with their antimicrobial effect.
Martina Balazinski, Ansgar Schmidt-Bleker, Jörn Winter, Thomas von Woedtke   +3 more
doaj   +2 more sources

The inflammatory oxidant peroxynitrous acid modulates the structure and function of the recombinant human V3 isoform of the extracellular matrix proteoglycan versican [PDF]

Redox Biology, 2023
Continued oxidant production during chronic inflammation generates host tissue damage, with this being associated with pathologies including atherosclerosis.
Sara M. Jørgensen, Lasse G. Lorentzen, Astrid Hammer, Gerald Hoefler, Ernst Malle, Christine Y. Chuang, Michael J. Davies   +6 more
doaj   +2 more sources

Identification and quantification of protein nitration sites in human coronary artery smooth muscle cells in the absence and presence of peroxynitrous acid/peroxynitrite [PDF]

Redox Biology, 2023
Peroxynitrous acid/peroxynitrite (ONOOH/ONOO−) is a powerful oxidizing/nitrating system formed at sites of inflammation, which can modify biological targets, and particularly proteins.
Shuqi Xu, Christine Y. Chuang, Clare L. Hawkins, Per Hägglund, Michael J. Davies   +4 more
doaj   +2 more sources

Oxidation of Aldehydes Used as Food Additives by Peroxynitrite [PDF]

Antioxidants, 2023
Benzaldehyde and its derivatives are used as food supplements. These substances can be used mainly as flavorings or as antioxidants. Besides, peroxynitrite, an oxidizing agent, could be formed in canned food. Both species could react between them.
Clara I. Alcolado, Luis Garcia-Rio, Juan C. Mejuto, Inmaculada Moreno, Francisco J. Poblete, Juan Tejeda   +5 more
doaj   +2 more sources

Sporicidal and bactericidal efficacy of plasma-treated liquids based on reaction kinetics of peroxynitrous acid [PDF]

Frontiers in Microbiology
IntroductionPlasma-treated aqueous solutions have proven effective for the inactivation of bacteria and even dormant spores. However, reported efficacies vary considerably across setups and experimental conditions.
Alexander Pogoda, Veronika Hahn, Klaus-Dieter Weltmann, Juergen F. Kolb, Juergen F. Kolb   +4 more
doaj   +2 more sources

Alexander disease mutations differentially sensitize glial fibrillary acidic protein (GFAP) to posttranslational modifications and network disruption by oxidants [PDF]

Redox Biology
The type III intermediate filament protein glial fibrillary acidic protein (GFAP) plays a key role in astrocyte and brain homeostasis. Mutations in GFAP can result in Alexander's disease (AxD), a severe neurodegenerative disease.
Nuria Goya-Iglesias, Per Hägglund, Paula Martínez-Cenalmor, Tina Nybo, Lasse G. Lorentzen, María A. Pajares, Michael J. Davies, Dolores Pérez-Sala   +7 more
doaj   +2 more sources

Mitochondria Play Essential Roles in Intracellular Protection against Oxidative Stress—Which Molecules among the ROS Generated in the Mitochondria Can Escape the Mitochondria and Contribute to Signal Activation in Cytosol? [PDF]

Biomolecules
Questions about which reactive oxygen species (ROS) or reactive nitrogen species (RNS) can escape from the mitochondria and activate signals must be addressed.
Daisuke Masuda, Ikuo Nakanishi, Kei Ohkubo, Hiromu Ito, Ken-ichiro Matsumoto, Hiroshi Ichikawa, Moragot Chatatikun, Wiyada Kwanhian Klangbud, Manas Kotepui, Motoki Imai, Fumitaka Kawakami, Makoto Kubo, Hirofumi Matsui, Jitbanjong Tangpong, Takafumi Ichikawa, Toshihiko Ozawa, Hsiu-Chuan Yen, Daret K. St Clair, Hiroko P. Indo, Hideyuki J. Majima   +19 more
doaj   +2 more sources

On the Proton Affinity of Peroxynitrite and Peroxynitrous Acid

Croatica Chemica Acta, 2001
The proton affinity (PA) of peroxynitrite (ONOO-) and peroxynitrous acid (ONOOH) are calculated to be 1440.5 kJ mol-1 and 749.8 kJ mol-1, respectively. Comparison with results for the nitrous, nitric and peroxynitric acid and their anions supports these estimates.
Kazazić, Saša, Kazazić, Snježana, Klasinc, Leo, McGlynn, Sean P., Pryor, William A.   +4 more
openaire   +6 more sources

Oxidant-modified amylin fibrils and aggregates alter the inflammatory profile of multiple myeloid cell types, but are non-toxic to islet β cells

Redox Biology, 2023
Diabetes mellitus currently affects ∼10% of the population worldwide, with Type 2 predominating, and this incidence is increasing steadily. Both Type 1 and 2 are complex diseases, involving β-cell death and chronic inflammation, but the pathways involved
Ramona Clemen, Eduardo Fuentes-Lemus, Sander Bekeschus, Michael J. Davies   +3 more
doaj   +1 more source