Results 21 to 30 of about 1,846 (182)

Absolute quantitative analysis of intact and oxidized amino acids by LC-MS without prior derivatization

Redox Biology, 2020
The precise characterization and quantification of oxidative protein damage is a significant challenge due to the low abundance, large variety, and heterogeneity of modifications.
Luke F. Gamon, Chaorui Guo, Jianfei He, Per Hägglund, Clare L. Hawkins, Michael J. Davies   +5 more
doaj   +1 more source

The Balancing of Peroxynitrite Detoxification between Ferric Heme-Proteins and CO₂: The Case of Zebrafish Nitrobindin

Antioxidants, 2022
Nitrobindins (Nbs) are all-β-barrel heme proteins and are present in prokaryotes and eukaryotes. Although their function(s) is still obscure, Nbs trap NO and inactivate peroxynitrite.
Giovanna De Simone, Andrea Coletta, Alessandra di Masi, Massimo Coletta, Paolo Ascenzi   +4 more
doaj   +1 more source

Quantification and Mechanisms of Oxidative Stress in Chronic Disease

Proceedings, 2019
There is now strong evidence that the redox environment inside cells is very different to that outside the cell, and that many extracellular environments are both more oxidizing and also subject to extensive oxidation.
Michael J. Davies
doaj   +1 more source

From reactive species to disease development: Effect of oxidants and antioxidants on the cellular biomarkers

Journal of Biochemical and Molecular Toxicology, Volume 37, Issue 11, November 2023., 2023
Abstract The influence of modern lifestyle, diet, exposure to chemicals such as phytosanitary substances, together with sedentary lifestyles and lack of exercise play an important role in inducing reactive stress (RS) and disease. The imbalance in the production and scavenging of free radicals and the induction of RS (oxidative, nitrosative, and ...
Celia María Curieses Andrés, José Manuel Pérez de la Lastra, Celia Andrés Juan, Francisco J. Plou, Eduardo Pérez‐Lebeña   +4 more
wiley   +1 more source

Gene network analysis to determine the effect of hypoxia-associated genes on brain damages and tumorigenesis using an avian model

Journal of Genetic Engineering and Biotechnology, 2021
Background Hypoxia refers to the condition of low oxygen pressure in the atmosphere and characterization of response to hypoxia as a biological complex puzzle, is challenging.
Hamed Kharrati-Koopaee, Esmaeil Ebrahimie, Mohammad Dadpasand, Ali Niazi, Rugang Tian, Ali Esmailizadeh   +5 more
doaj   +1 more source

Plasma‐treated liquids in medicine: Let's get chemical

Plasma Processes and Polymers, Volume 20, Issue 9, September 2023., 2023
Knowing the chemical composition of plasma‐treated liquids is fundamental for their introduction to the clinic and to avoid overselling plasma treatment in situations where the same solutions could be obtained by simply mixing together the individual components.
Francesco Tampieri, Yury Gorbanev, Eloisa Sardella   +2 more
wiley   +1 more source

Identification and quantification of sites of nitration and oxidation in the key matrix protein laminin and the structural consequences of these modifications

Redox Biology, 2019
Laminin is a major protein of the basement membrane (BM), a specialized extracellular matrix (ECM) of the artery wall. The potent oxidizing and nitrating agent peroxynitrous acid (ONOOH) is formed at sites of inflammation, and data implicate ONOOH in ECM
Lasse G. Lorentzen, Christine Y. Chuang, Adelina Rogowska-Wrzesinska, Michael J. Davies   +3 more
doaj   +1 more source

The chemistry of peroxynitrite, a biological toxin

Química Nova, 1998
Oxyradicals play a tole in several diseases. While for several decades the hydroxyl radical - produced via the Fenton reaction - has been considered the species that initiates oxyradical damage, new findings suggest that much of this damage can be ...
W. H. Koppenol
doaj   +1 more source

Modification of DNA structure by reactive nitrogen species as a result of 2-methoxyestradiol–induced neuronal nitric oxide synthase uncoupling in metastatic osteosarcoma cells

Redox Biology, 2020
2-methoxyestradiol (2-ME) is a physiological anticancer compound, metabolite of 17β-estradiol. Previously, our group evidenced that from mechanistic point of view one of anticancer mechanisms of action of 2-ME is specific induction and nuclear hijacking ...
Magdalena Gorska-Ponikowska, Agata Ploska, Dagmara Jacewicz, Michal Szkatula, Giampaolo Barone, Giosuè Lo Bosco, Fabrizio Lo Celso, Aleksandra M Dabrowska, Alicja Kuban-Jankowska, Monika Gorzynik-Debicka, Narcyz Knap, Lech Chmurzynski, Lawrence Wawrzyniec Dobrucki, Leszek Kalinowski, Michal Wozniak   +14 more
doaj   +1 more source

Cardiac spheroids as promising in vitro models to study the human heart microenvironment

Scientific Reports, 2017
Three-dimensional in vitro cell systems are a promising alternative to animals to study cardiac biology and disease. We have generated three-dimensional in vitro models of the human heart (“cardiac spheroids”, CSs) by co-culturing human primary or iPSC ...
Liudmila Polonchuk, Mamta Chabria, Laura Badi, Jean-Christophe Hoflack, Gemma Figtree, Michael J. Davies, Carmine Gentile   +6 more
doaj   +1 more source