Results 111 to 120 of about 983,813 (313)

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

Italian Equity Funds: Efficiency and Performance Persistence [PDF]

Have Italian mutual funds been able to generate “extra-return”? Were some of them able to persistently beat the competitors? In this paper we address these questions and provide a detailed and systematic performance and return persistence analysis of the
Roberto Casarin, Andrea Piva, Loriana Pelizzon   +2 more
core  

Persistent Mayer homology and persistent Mayer Laplacian

Foundations of Data Science
In algebraic topology, the differential (i.e., boundary operator) typically satisfies $d^{2}=0$. However, the generalized differential $d^{N}=0$ for an integer $N\geq 2$ has been studied in terms of Mayer homology on $N$-chain complexes for more than eighty years. We introduce Mayer Laplacians on $N$-chain complexes.
Shen, Li, Liu, Jian, Wei, Guo-Wei
openaire   +4 more sources

The persistence of persistence in the research world

, 2021
Timmer (2021) raised the issue of perceived value and persistent use of a persistent and very serious problem in humankind's scientific inquiries: replicability problems. Apparently, reading Timmer's makes serious scientists and academics—who have embraced basic ethical standards—both worried and disappointed.
openaire   +2 more sources

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Optimising Microfoundations for Inflation Persistence [PDF]

We connect two major strands of the recent monetary policy literature, i) the search for well microfounded optimising models consistent with macroeconomic data, especially persistence in inflation, and ii) the wealth of newly available microeconomic data
Richard Mash
core  

Persistence in the Methadone Maintenance Program and Its Relationship with the Medication Regimen Complexity Index in Opioid-Dependent Patients

Pharmaceuticals
It has been shown that the Medication Regimen Complexity Index (MRCI) is a useful and reliable tool for calculating the complexity of the pharmacotherapeutic regimen (CPR). Furthermore, a high MRCI is associated with lower adherence. However, the MRCI of
Elena Alba Álvaro-Alonso, María del Carmen Gómez-Álvarez, Beatriz Segovia-Tapiador, María Isabel Del-Pino-Illaconza, Jorge Valencia, Pablo Ryan, Antonio Aguilar-Ros, Ismael Escobar-Rodríguez   +7 more
doaj   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Cross-Sectional Aggregation and Persistence in Conditional Variance [PDF]

This paper explores the interactions between cross-sectional aggregation and persistence of volatility shocks. We derive the ARMA-GARCH representation that linear aggregates of ARMA processes with GARCH errors admit, and establish conditions under which ...
Menelaos Karanasos, Zacharias Psaradakis, Martin Sola   +2 more
core  

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source