Results 21 to 30 of about 606,469 (298)

Quorum Sensing-Regulated Phenol-Soluble Modulins Limit Persister Cell Populations in Staphylococcus aureus

Frontiers in Microbiology, 2018
Incomplete killing of bacterial pathogens by antibiotics is an underlying cause of treatment failure and accompanying complications. Among those avoiding chemotherapy are persisters being individual cells in a population that for extended periods of time
Martin S. Bojer, Martin S. Bojer, Søren Lindemose, Martin Vestergaard, Hanne Ingmer, Hanne Ingmer   +5 more
doaj   +1 more source

Interred mechanisms of resistance and host immune evasion revealed through network-connectivity analysis of M. tuberculosis complex graph pangenome

mSystems
Mycobacterium tuberculosis complex successfully adapts to environmental pressures through mechanisms of rapid adaptation which remain poorly understood despite knowledge gained through decades of research.
Monica E. Espinoza, Ashley M. Swing, Afif Elghraoui, Samuel J. Modlin, Faramarz Valafar   +4 more
doaj   +1 more source

Optimal Maturation of the SIV-Specific CD8+ T Cell Response after Primary Infection Is Associated with Natural Control of SIV: ANRS SIC Study

Cell Reports, 2020
Summary: Highly efficient CD8+ T cells are associated with natural HIV control, but it has remained unclear how these cells are generated and maintained.
Caroline Passaes, Antoine Millet, Vincent Madelain, Valérie Monceaux, Annie David, Pierre Versmisse, Naya Sylla, Emma Gostick, Sian Llewellyn-Lacey, David A. Price, Antoine Blancher, Nathalie Dereuddre-Bosquet, Delphine Desjardins, Gianfranco Pancino, Roger Le Grand, Olivier Lambotte, Michaela Müller-Trutwin, Christine Rouzioux, Jérémie Guedj, Véronique Avettand-Fenoel, Bruno Vaslin, Asier Sáez-Cirión   +21 more
doaj   +1 more source

What they see, what they say: The everyday reality of being a migrant ‘Other’

Social Sciences and Humanities Open
This study investigates Othering among Iraqi Kurdish migrants in the UK, emphasising its emotional, spatial, linguistic, and embodied dimensions. Through qualitative interviews, it reveals how exclusion is not only experienced externally but also ...
Chra Rasheed Mahmud
doaj   +1 more source

Using of Tenebrio molitor larvae to study the toxicity of heavy metals [PDF]

BIO Web of Conferences
Studies of environmental pollution by heavy metals associated with the outpouring of mine waters onto the soil surface and the flushing of heavy metal solutions into reservoirs from the dumps of copper ores are relevant for the mining regions of the ...
Zhurlov Oleg
doaj   +1 more source

Psychosocial Outcomes in Patients With Endocrine Tumor Syndromes: A Systematic Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction The combination of disease manifestations, the familial burden, and varying penetrance of endocrine tumor syndromes (ETSs) is unique. This review aimed to portray and summarize available data on psychosocial outcomes in patients with ETSs and explore gaps and opportunities for future research and care.
Daniël Zwerus, Floortje Strobbe, Annemarie A. Verrijn Stuart, Hanneke M. van Santen, Gerlof D. Valk, Sasja A. Schepers, Rachel S. van Leeuwaarde   +6 more
wiley   +1 more source

Intramolecular Interactions Dominate the Autoregulation of Escherichia coli Stringent Factor RelA

Frontiers in Microbiology, 2019
Amino acid starvation in Escherichia coli activates the enzymatic activity of the stringent factor RelA, leading to accumulation of the alarmone nucleotide (p)ppGpp.
Kathryn Jane Turnbull, Kathryn Jane Turnbull, Kathryn Jane Turnbull, Ievgen Dzhygyr, Ievgen Dzhygyr, Søren Lindemose, Vasili Hauryliuk, Vasili Hauryliuk, Vasili Hauryliuk, Mohammad Roghanian, Mohammad Roghanian, Mohammad Roghanian   +11 more
doaj   +1 more source

Persister Awakening [PDF]

Molecular Cell, 2016
In this issue of Molecular Cell, Cheverton et al. (2016) report that Samonella toxin TacT contributes to persister formation by acetylating tRNA, a novel mechanism of toxin action. Hydrolyzing corrupted tRNA resuscitates persisters.
Kim, Lewis, Yue, Shan
openaire   +2 more sources

Changes in Body Composition in Children and Young People Undergoing Treatment for Acute Lymphoblastic Leukemia: A Systematic Review and Meta‐Analysis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Ongoing evidence indicates increased risk of sarcopenic obesity among children and young people (CYP) with acute lymphoblastic leukemia (ALL), often beginning early in treatment, persisting into survivorship. This review evaluates current literature on body composition in CYP with ALL during and after treatment.
Lina A. Zahed, Raquel Revuelta Iniesta, Mary Fewtrell, Julie Lanigan, Breeana Gardiner, Graeme O'Connor   +5 more
wiley   +1 more source

Novel and reported compensatory mutations in rpoABC genes found in drug resistant tuberculosis outbreaks

Frontiers in Microbiology
BackgroundRifampicin (RIF) is a key first-line drug used to treat tuberculosis, a primarily pulmonary disease caused by Mycobacterium tuberculosis. RIF resistance is caused by mutations in rpoB, at the cost of slower growth and reduced transcription ...
Derek Conkle-Gutierrez, Sarah M. Ramirez-Busby, Bria M. Gorman, Afif Elghraoui, Sven Hoffner, Sven Hoffner, Wael Elmaraachli, Faramarz Valafar   +7 more
doaj   +1 more source