Results 21 to 30 of about 983,813 (313)

Persistent Pandemics

open access: yesEconomics & Human Biology, 2021
We ask whether mortality from historical pandemics has any predictive content for mortality in the Covid-19 pandemic. We find strong persistence in public health performance. Places that performed worse in terms of mortality in the 1918 influenza pandemic also have higher Covid-19 mortality today.
Peter Z. Lin, Christopher M. Meissner
openaire   +5 more sources

PERSISTENCE IN CONVERGENCE [PDF]

open access: yesMacroeconomic Dynamics, 2013
In this paper, we examine the convergence hypothesis using a long memory framework that allows for structural breaks and does not rely on a benchmark country. We find that even though the long memory framework of analysis is much richer than the simple I(1)/I(0) alternative, a simple absolute divergence and rapid convergence dichotomy produced by the ...
Thanasis Stengos, M. Ege Yazgan
openaire   +3 more sources

Prophages and Growth Dynamics Confound Experimental Results with Antibiotic-Tolerant Persister Cells

open access: yesmBio, 2017
Bacterial persisters are phenotypic variants that survive antibiotic treatment in a dormant state and can be formed by multiple pathways. We recently proposed that the second messenger (p)ppGpp drives Escherichia coli persister formation through protease
Alexander Harms   +4 more
doaj   +1 more source

PasT of Escherichia coli sustains antibiotic tolerance and aerobic respiration as a bacterial homolog of mitochondrial Coq10

open access: yesMicrobiologyOpen, 2020
Antibiotic‐tolerant persisters are often implicated in treatment failure of chronic and relapsing bacterial infections, but the underlying molecular mechanisms have remained elusive.
Cinzia Fino   +5 more
doaj   +1 more source

Serine-Threonine Kinases Encoded by Split hipA Homologs Inhibit Tryptophanyl-tRNA Synthetase

open access: yesmBio, 2019
Type II toxin-antitoxin (TA) modules encode a stable toxin that inhibits cell growth and an unstable protein antitoxin that neutralizes the toxin by direct protein-protein contact.
Stine Vang Nielsen   +7 more
doaj   +1 more source

Pyrazinamide Susceptibility Is Driven by Activation of the SigE-Dependent Cell Envelope Stress Response in Mycobacterium tuberculosis

open access: yesmBio, 2022
Pyrazinamide (PZA) plays a crucial role in first-line tuberculosis drug therapy. Unlike other antimicrobial agents, PZA is active against Mycobacterium tuberculosis only at low pH. The basis for this conditional drug susceptibility remains undefined.
Joshua M. Thiede   +8 more
doaj   +1 more source

Zigzag Persistence [PDF]

open access: yesFoundations of Computational Mathematics, 2010
We describe a new methodology for studying persistence of topological features across a family of spaces or point-cloud data sets, called zigzag persistence. Building on classical results about quiver representations, zigzag persistence generalises the highly successful theory of persistent homology and addresses several situations which are not ...
Gunnar E. Carlsson, Vin de Silva
openaire   +5 more sources

HipA-Mediated Phosphorylation of SeqA Does not Affect Replication Initiation in Escherichia coli

open access: yesFrontiers in Microbiology, 2018
The SeqA protein of Escherichia coli is required to prevent immediate re-initiation of chromosome replication from oriC. The SeqA protein is phosphorylated at the serine-36 (Ser36) residue by the HipA kinase.
Leise Riber   +4 more
doaj   +1 more source

Persistently Finite, Persistently Arithmetic Theories [PDF]

open access: yesProceedings of the American Mathematical Society, 1983
The main result shows that a certain class of theories, the persistently finite, persistently arithmetic theories, have only arithmetic countable models.
Ash, C. J., Millar, T. S.
openaire   +2 more sources

Phylogeny Reveals Novel HipA-Homologous Kinase Families and Toxin-Antitoxin Gene Organizations

open access: yesmBio, 2021
Bacterial multidrug tolerance and persistence are problems of increasing scientific and medical significance.
Kenn Gerdes   +2 more
doaj   +1 more source

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