Results 101 to 110 of about 13,899 (258)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Verification under Intel-x86 with Persistency

The full semantics of the Intel-x86 architecture has been defined by Raad et al in POPL 2022, extending the earlier formalization based on the TSO memory model incorporating persistency. This new semantics involves an intricate combination of the SC, TSO,
Atig, Mohamed Faouzi,, Kumar, K. Narayan,, Saivasan, Prakash,, Bouajjani, Ahmed, Atig, Mohamed Faouzi, Abdulla, Parosh, Saivasan, Prakash, Bouajjani, Ahmed,, Kumar, K. Narayan, Abdulla, Parosh,   +9 more
core   +1 more source

Produção de leite de vacas da raça Holandesa de pequeno, médio e grande porte Milk production of Holstein cows in small, medium and large size

Ciência Rural, 2011
O objetivo deste estudo foi avaliar o efeito do composto corporal sobre a produção de leite de vacas da raça Holandesa de primeira, segunda e terceira lactação. Para avaliação, foram usadas 133 vacas, selecionadas de um rebanho de 280 animais em lactação,
Décio Adair Rebellatto da Silva, Clair Jorge Olivo, Ben-Hur Costa de Campos, Thiago Moreira Tejkowski, Gilmar Roberto Meinerz, Ana Gabriela de Freitas Saccol, Silvio Teixeira da Costa   +6 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

VecGeom persistency using ROOT

, 2018
This project aims to create a persistency layer for VecGeom geometry objects, using ROOT I/O and genreflex tool. The final produced code can correctly save and load a simple VecGeom geometry with all available volumes and ...
Senacheribbe, Andrea
core  

Avaliação de modelos não-lineares e da relação do consumo voluntário de vacas primíparas e de bezerros com a curva de lactação de vacas Nelore Evaluation of non-linear models and the effects of primiparous cows and calves intake on the lactation curve of Nelore cows

Revista Brasileira de Zootecnia, 2011
Procurou-se avaliar a precisão de cinco modelos não-lineares em descrever a forma da curva de produção de leite de vacas Nelore e o efeito do consumo voluntário (CV) da vaca e do bezerro sobre a produção de leite (PL). Foram testados os modelos de Sikka,
Lara Toledo Henriques, Sebastião de Campos Valadares Filho, Mozart Alves Fonseca, Pedro Veiga Rodrigues Paulino, Edenio Detmann, Rilene Ferreira Diniz Valadares   +5 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

THE LOGIC OF BELIEF PERSISTENCY [PDF]

The interaction bietween knowledge and belief in a temporal context is analyzed. An axiomatic formulation and semantic characterization of the principle of belief persistency implied by the standard conditionalization rule are provided.
Giacomo Bonanno, Pierpaolo Battigalli
core  

Perawatan Impaksi Gigi Premolar Pertama Mandibula Pada Maloklusi Angle Klas II Divisi 2 Subdivisi Dengan Teknik Be

Majalah Kedokteran Gigi Indonesia, 2013
Impaksi gigi terjadi karena gigi gagal untuk erupsi secara sempurna pada posisinya akibat terhalang oleh gigi lain maupun jaringan lunak atau padat di sekitarnya.
Apreka Tigor Kusumasmara, Wayan Ardhana, Christnawati Christnawati   +2 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source