Results 101 to 110 of about 16,153 (254)
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
Challenges in Empirically Testing Memory Persistency Models
Memory persistency models provide the foundational rules for software engineers to develop applications that take advantage of non-volatile memory (NVM), dictating which (and when) writes to NVM are deemed persistent.
Raad, A +5 more
core +1 more source
The ubiquitin system in normal and infected germinal center B cells
FEBS Letters, EarlyView.The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis +2 more
wiley +1 more source
VecGeom persistency using ROOT
, 2018 This project aims to create a persistency layer for VecGeom geometry objects, using ROOT I/O and genreflex tool. The final produced code can correctly save and load a simple VecGeom geometry with all available volumes and ...
Senacheribbe, Andrea
core
FEBS Letters, EarlyView.Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley +1 more source
Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research
FEBS Letters, EarlyView.What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
THE LOGIC OF BELIEF PERSISTENCY [PDF]
The interaction bietween knowledge and belief in a temporal context is analyzed. An axiomatic formulation and semantic characterization of the principle of belief persistency implied by the standard conditionalization rule are provided.
Giacomo Bonanno, Pierpaolo Battigalli
core
Lactation Persistency in Bulgarian Murrah Buffalo Cows [PDF]
, 2013 With the objective to establish the lactation persistency and its variability as affected by different factors, the study assigned 953 lactations of 310 Bulgarian Murrah buffalo cows bred on the farm of Agricultural Institute – Shumen within the period ...
Peeva, Tz., Penchev, P.
core
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source