Results 111 to 120 of about 16,153 (254)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
An approximation algorithm for a generalized assignment problem with small resource requirements. [PDF]
We investigate a generalized assignment problem where the resource requirements are either 1 or 2. This problem is motivated by a question that arises when data blocks are to be retrieved from parallel disks as efficiently as possible.
Aerts, J, Korst, J, Spieksma, Frederik
core
, 2013 Persistency of lactation in indigenous and crossbred cows was studied using milk data collected at Bako Agricultural Research Centre. Persistency was measured using three methods vis a vis as the ratios of milk yield during the second (P2:1) and third ...
Diedhiou, M.L. +3 more
core +1 more source
Do shocks last forever? Local persistency in economic time series
, 2007 While it is recognized that many macroeconomic time series are highly persistent over certain range, less persistent results are also found around very long horizons, indicating the existence of local or temporary persistency.
Xiao, Zhijie +1 more
core +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
WAGE ADJUSTMENT AND EMPLOYMENT PERSISTENCY
Persistent high unemployment has fostered the employment persistency hypothesis according to which employment changes are driven by unanticipated shocks whereas anticipated shocks that potentially could change employment are absorbed by wage changes ...
Hylleberg, Svend, Andersen, Torben M.
core
The Logic of Belief Persistency
, 1995 The interaction bietween knowledge and belief in a temporal context is analyzed. An axiomatic formulation and semantic characterization of the principle of belief persistency implied by the standard conditionalization rule are provided.
Battigalli, Pierpaolo, Bonanno, Giacomo
core
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source