Results 111 to 120 of about 1,043,448 (307)
Molecular Oncology, EarlyView.A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath +13 more
wiley +1 more source
Combinatorial presentation of multidimensional persistent homology [PDF]
, 2014 A multifiltration is a functor indexed by $\mathbb{N}^r$ that maps any morphism to a monomorphism. The goal of this paper is to describe in an explicit and combinatorial way the natural $\mathbb{N}^r$-graded $R[x_1,\ldots, x_r]$-module structure on the ...
Chacholski, Wojciech +2 more
core +1 more source
Visual Detection of Structural Changes in Time-Varying Graphs Using Persistent Homology
, 2017 Topological data analysis is an emerging area in exploratory data analysis and data mining. Its main tool, persistent homology, has become a popular technique to study the structure of complex, high-dimensional data.
Hajij, Mustafa +3 more
core +1 more source
Persistent homology and non-Gaussianity [PDF]
Journal of Cosmology and Astroparticle Physics, 2018 21 pages, 11 ...
Cole, Alex, Shiu, Gary
openaire +2 more sources
Compression for 2-parameter persistent homology
Computational Geometry, 2023 Compression aims to reduce the size of an input, while maintaining its relevant properties. For multi-parameter persistent homology, compression is a necessary step in any computational pipeline, since standard constructions lead to large inputs, and computational tasks in this area tend to be expensive.
Fugacci Ulderico +2 more
openaire +3 more sources
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Analysis of Kolmogorov Flow and Rayleigh-B\'enard Convection using Persistent Homology
, 2015 We use persistent homology to build a quantitative understanding of large complex systems that are driven far-from-equilibrium; in particular, we analyze image time series of flow field patterns from numerical simulations of two important problems in ...
Kramar, Miroslav +7 more
core +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Persistent Homology for Random Fields and Complexes
, 2010 We discuss and review recent developments in the area of applied algebraic topology, such as persistent homology and barcodes. In particular, we discuss how these are related to understanding more about manifold learning from random point cloud data, the
Adler, Robert J. +4 more
core +2 more sources
Persistent Homology and Persistent Cohomology: A Review
Earthline Journal of Mathematical SciencesPersistent homology is an important tool in non-linear data reduction. Its sister theory, persistent cohomology, has attracted less attention in the past years eventhough it has many advantages. Several literatures dealing with theory and computations of
Busayo Adeyege Okediji, A. Oladipo
semanticscholar +1 more source