Results 91 to 100 of about 54,259 (246)
PET Imaging of Cardiac Inflammation in Viral Myocarditis Using a DPP4‐Targeted Probe
Advanced Science, EarlyView.This study describes a DPP4‐targeted PET probe for imaging myocardial inflammation by selectively targeting activated immune cells. Derived from the clinically approved small‐molecule inhibitor linagliptin, the probe demonstrates favorable biodistribution with specific cardiac uptake in myocarditis.
Wanhao Gao +14 more
wiley +1 more source
GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy
Advanced Science, EarlyView.Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu +11 more
wiley +1 more source
, 2008 We show that the persistent homology of a filtered d-dimensional simplicial complex is simply the standard homology of a particular graded module over a polynomial ring.
Gunnar Carlsson, Afra Zomorodian
core
Advanced Science, EarlyView.Canagliflozin treatment reshapes the gut microbiota in DKD and elevates levels of melibiose, a metabolite derived from Roseburia intestinalis. Melibiose directly binds to and enhances the enzymatic activity of glyoxalase 1, leading to decreased methylglyoxal accumulation.
Wei Zhang +32 more
wiley +1 more source
Computing Persistent Homology Modules
, 2015 Computational topology uses persistence to distinguish noise from data. Computing persistent homology modules for simplicial complexes built out of point cloud data helps to determine the ``shape'' of data.
Hubbard, Mike
core
Persistent Homology and Applications to Graph Data
, 2023 https://rdc.reed.edu/v1/resources/9db4e056-ea0b-46fa-89af-7479b1ab6de4/thumb/128.jpgTopological Data Analysis (TDA) is a field in applied mathematics that studies how theory from topology can be used to build tools to analyze data. Persistent homology is
McGough, Olivia
core
Self‐Assembling Hybrid Hydrogel Reprograms the Stromal Vascular Fraction to Treat Osteoarthritis
Advanced Science, EarlyView.This study presents a bioinspired injectable hydrogel that enhances the therapeutic potential of stem cell‐rich stromal vascular fraction for treating osteoarthritis. By reprogramming cell behavior through epigenetic modulation, the hydrogel promotes cartilage regeneration and reduces joint damage in a rat model, offering a promising new approach for ...
Waifang Hou +23 more
wiley +1 more source
Persistent Mayer homology and persistent Mayer Laplacian
Foundations of Data ScienceIn algebraic topology, the differential (i.e., boundary operator) typically satisfies $d^{2}=0$. However, the generalized differential $d^{N}=0$ for an integer $N\geq 2$ has been studied in terms of Mayer homology on $N$-chain complexes for more than eighty years. We introduce Mayer Laplacians on $N$-chain complexes.
Shen, Li, Liu, Jian, Wei, Guo-Wei
openaire +4 more sources
Photonic band structure design using persistent homology
, 2020 The machine learning technique of persistent homology classifies complex systems or datasets by computing their topological features over a range of characteristic scales. There is growing interest in applying persistent homology to characterize physical
Dimitris G Angelakis (17521500) +1 more
core +1 more source
Advanced Science, EarlyView.The pholidota‐inspired electronic skin is successfully constructed, originally realized four‐state reversible switching of terahertz‐wave reflection, absorption, transmission, and secondary reflection. In response to external demands, it issues deformation instructions, verifies the deformation state after the equipment executes the action, and thus ...
Shangjing Li +4 more
wiley +1 more source