Results 91 to 100 of about 714,887 (284)

Spatial Pyramid Bag of Words Algorithm Based on Persistent Homology [PDF]

open access: yesJisuanji kexue
To address the mismatch between the output form of topological features extracted from persistent homology and the common input form of machine learning algorithms,this paper proposes a new algorithmic framework-Spatial Pyramid Bag of Words Algorithm ...
YI Lisha, PENG Ningning
doaj   +1 more source

Bredon homology and equivariant K-homology of SL(3,Z) [PDF]

open access: yes, 2008
We obtain the equivariant K-homology of the classifying space underline{E}SL(3,Z) from the computation of its Bredon homology with respect to finite subgroups and coefficients in the representation ring.
Sanchez-Garcia, Ruben
core   +1 more source

Heterotropic regulation and negative homotropic cooperativity

open access: yesFEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea   +5 more
wiley   +1 more source

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

open access: yesFEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez   +4 more
wiley   +1 more source

Parallel reduction of boundary matrices in Persistent Homology

open access: yes, 2019
Topological Data Analysis is a relatively new paradigm in data-science that models datasets as point-clouds sampled from a shape embedded in an Euclidean space.
Mendoza-Smith, Rodrigo
core   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

open access: yesAging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Elevated Connectivity During Language Processing Is Associated With Cognitive Performance in SeLECTS

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Self‐Limited Epilepsy with Centrotemporal Spikes (SeLECTS) is associated with language impairments despite seizures originating in the motor cortex, suggesting aberrant cross‐network interactions. Here we tested whether functional connectivity in SeLECTS during language tasks predicts language performance.
Wendy Qi   +8 more
wiley   +1 more source

Keeping it sparse: Computing Persistent Homology revisited

open access: yesComputing in Geometry and Topology
In this work, we study several variants of matrix reduction via Gaussian elimination that try to keep the reduced matrix sparse. The motivation comes from the growing field of topological data analysis where matrix reduction is the major subroutine to ...
Ulrich Bauer   +5 more
doaj   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem   +9 more
wiley   +1 more source

Persistent homology across signatures.

open access: yes, 2021
Persistent homology across signatures.
Steven Latré (11478193)   +3 more
core   +1 more source

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