Results 81 to 90 of about 714,887 (284)
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Cubical Homology-Based Machine Learning: An Application in Image Classification
Axioms, 2022 Persistent homology is a powerful tool in topological data analysis (TDA) to compute, study, and encode efficiently multi-scale topological features and is being increasingly used in digital image classification.
Seungho Choe, Sheela Ramanna
doaj +1 more source
Computing persistent homology in Futhark
, 2021 We present a massively parallel algorithm for computing persistent homology, a concept within the field of topological data analysis, and we implement it in the purely functional array-based language Futhark, which has an efficient compiler targeting ...
Erik von Brömssen +2 more
core +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Persistent Homology Analysis for Solar Magnetograms
The Astrophysical JournalUnderstanding the magnetic fields of the Sun is essential for unraveling the underlying mechanisms driving solar activity. Integrating topological data analysis techniques into these investigations can provide valuable insights into the intricate ...
P. Santamarina Guerrero +3 more
doaj +1 more source
Bot Detection on Social Networks Using Persistent Homology
Mathematical and Computational Applications, 2020 The growth of social media in recent years has contributed to an ever-increasing network of user data in every aspect of life. This volume of generated data is becoming a vital asset for the growth of companies and organizations as a powerful tool to ...
Minh Nguyen, Mehmet Aktas, Esra Akbas
doaj +1 more source
Evolution‐guided yeast complementation reveals functional differences in human PSPH variants
FEBS Open Bio, EarlyView.Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez +6 more
wiley +1 more source
, 2019 A fundamental tool in topological data analysis is persistent homology, which allows extraction of information from complex datasets in a robust way. Persistent homology assigns a module over a principal ideal domain to a one-parameter family of spaces ...
Schenck, Hal
core +1 more source
Stochastic convergence of persistence landscapes and silhouettes
Journal of Computational Geometry, 2015 Persistent homology is a widely used tool in Topological Data Analysis that encodes multi-scale topological information as a multiset of points in the plane called a persistence diagram.
Frédéric Chazal +4 more
doaj +1 more source
FEBS Open Bio, EarlyView.Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty +13 more
wiley +1 more source