Results 71 to 80 of about 52,327 (248)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Persistent homology of NBA lineups usage

Journal of Sports Analytics
We present a method to analyze lineup usage patterns in the NBA, based on topological data analysis. Traditional network analysis is based on which pairs of players are on the court together.
Jim Wiseman
doaj   +1 more source

Bot Detection on Social Networks Using Persistent Homology

Mathematical and Computational Applications, 2020
The growth of social media in recent years has contributed to an ever-increasing network of user data in every aspect of life. This volume of generated data is becoming a vital asset for the growth of companies and organizations as a powerful tool to ...
Minh Nguyen, Mehmet Aktas, Esra Akbas
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Persistent Homology Analysis for Solar Magnetograms

The Astrophysical Journal
Understanding the magnetic fields of the Sun is essential for unraveling the underlying mechanisms driving solar activity. Integrating topological data analysis techniques into these investigations can provide valuable insights into the intricate ...
P. Santamarina Guerrero, Yukio Katsukawa, Shin Toriumi, D. Orozco Suárez   +3 more
doaj   +1 more source

Stochastic convergence of persistence landscapes and silhouettes

Journal of Computational Geometry, 2015
Persistent homology is a widely used tool in Topological Data Analysis that encodes multi-scale topological information as a multiset of points in the plane called a persistence diagram.
Frédéric Chazal, Brittany Terese Fasy, Fabrizio Lecci, Alessandro Rinaldo, Larry Wasserman   +4 more
doaj   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Spatial Pyramid Bag of Words Algorithm Based on Persistent Homology [PDF]

Jisuanji kexue
To address the mismatch between the output form of topological features extracted from persistent homology and the common input form of machine learning algorithms,this paper proposes a new algorithmic framework－Spatial Pyramid Bag of Words Algorithm ...
YI Lisha, PENG Ningning
doaj   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source