Results 71 to 80 of about 54,259 (246)
Chromosomal Instability Drives Glioblastoma Heterogeneity and Therapeutic Opportunities
Advanced Science, EarlyView.ABSTRACT Glioblastoma, the most aggressive and lethal form of brain cancer, is defined by profound genomic instability, with Chromosomal Instability (CIN) playing a central role in driving tumor progression, therapy resistance, and poor prognosis. CIN is characterized by numerical and structural alterations, is driven by mechanisms such as mitotic ...
Amarnath Pal +3 more
wiley +1 more source
Künneth Formulae in Persistent Homology
CoRR, 2019 The classical Künneth formula in algebraic topology describes the homology of a product space in terms of that of its factors. In this paper, we prove Künneth-type theorems for the persistent homology of the categorical and tensor product of filtered spaces.
Hitesh Gakhar, Jose A. Perea
openaire +2 more sources
Parallel reduction of boundary matrices in Persistent Homology
, 2019 Topological Data Analysis is a relatively new paradigm in data-science that models datasets as point-clouds sampled from a shape embedded in an Euclidean space.
Mendoza-Smith, Rodrigo
core
Advanced Science, EarlyView.Our study reveals the protective role of GPR124 in maintaining BBB integrity and promoting neurological recovery following TBI. It makes a significant contribution by uncovering a novel molecular interaction between GPR124 and FGFBP1 and linking this to activation of the Wnt/β‐catenin signaling pathway in vascular repair mechanisms.
Chen Wang +13 more
wiley +1 more source
Coreduction homology algorithm for inclusions and persistent homology
Computers & Mathematics with Applications, 2010 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Marian Mrozek, Thomas Wanner
openaire +3 more sources
PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC
Advanced Science, EarlyView.CD4+ tissue‐resident memory T cells (TRMs) in non‐small cell lung cancer recruit conventional type 1 dendritic cells via XCL1‐XCR1 signaling, orchestrating antitumor immunity. The costimulatory molecule JAML is essential for this process. PD‐1 blockade restores JAML expression and cDC1 mobilization, while JAML agonists synergize with anti‐PD‐1 therapy,
Zheyu Shao +16 more
wiley +1 more source
Multidimensional Discrete Morse Function for Persistent Homology Computation
, 2019 Our primary motivation for persistent homology is in its applications to shape similarity measures. Multidimensional or multiparameter persistence comes into play in that context when two objects are to be simultaneously compared according to several ...
Kaczynski, Tomasz
core
The stability of persistent homology of hypergraphs
, 2023 Hypergraph is the most general model for complex networks involving group interactions. Taking the ideas of path homology from Alexander Grigor'yan, Yong Lin, Yuri Muranov and Shing-Tung Yau [18-22], Stephane Bressan, Jingyan Li and the authors of this ...
Ren, Shiquan, Wu, Jie
core
Photonic band structure design using persistent homology
, 2021 Summarization: The machine learning technique of persistent homology classifies complex systems or datasets by computing their topological features over a range of characteristic scales.
Angelakis Dimitrios(http://users.isc.tuc.gr/~daggelakis) +2 more
core +1 more source
Advanced Science, EarlyView.Malectin alleviates high glucose‐induced ER stress and damage in placental trophoblasts, a function dependent on its six critical carbohydrate‐binding residues. In a GDM mouse model, administration of TAT‐Malectin ameliorated hyperglycemia and placental ER stress and prevented fetal macrosomia.
Jiahui Zhu +12 more
wiley +1 more source