Results 61 to 70 of about 52,327 (248)
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Implementation of Persistent Homology in Survival Analysis for Correlated and Longitudinal Data: A case study of COVID-19 Spread in Indonesia [PDF]
ITM Web of ConferencesMost survival models assume no autocorrelation between objects and time-independence. However, in many cases of disease spread, an object can potentially affect its neighbors, and the feature may change over time.
Amartiwi Utih, Kholodov Yaroslav A.
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
ExperimedObjective: This study aimed to use a new approach, namely persistent homology, to analyse electroen cephalogram (EEG) coherence and identify the alterations in brain connectivity in patients with Alzheimer’s disease (AD).Materials and Methods: We applied
Atilla Uslu +3 more
doaj +1 more source
Frontiers in Aging Neuroscience, 2020 Current researches on default mode network (DMN) in normal elderly have mainly focused on finding some dysfunctional areas with decreased or increased connectivity. The global network dynamics of apolipoprotein E (APOE) e4 allele group is rarely studied.
Liqun Kuang +6 more
doaj +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Cluster Persistence for Weighted Graphs
Entropy, 2023 Persistent homology is a natural tool for probing the topological characteristics of weighted graphs, essentially focusing on their 0-dimensional homology.
Omer Bobrowski, Primoz Skraba
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Persistent Topological Laplacians—A Survey
MathematicsPersistent topological Laplacians constitute a new class of tools in topological data analysis (TDA). They are motivated by the necessity to address challenges encountered in persistent homology when handling complex data.
Xiaoqi Wei, Guo-Wei Wei
doaj +1 more source
Cubical Homology-Based Machine Learning: An Application in Image Classification
Axioms, 2022 Persistent homology is a powerful tool in topological data analysis (TDA) to compute, study, and encode efficiently multi-scale topological features and is being increasingly used in digital image classification.
Seungho Choe, Sheela Ramanna
doaj +1 more source