Results 41 to 50 of about 54,259 (246)
Journal of Applied and Computational Topology17 pages, 4 ...
Bernardo Ameneyro +2 more
openaire +3 more sources
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
Persistent hyperdigraph homology and persistent hyperdigraph Laplacians
Foundations of Data Science, 2023 Hypergraphs are useful mathematical models for describing complex relationships among members of a structured graph, while hyperdigraphs serve as a generalization that can encode asymmetric relationships in the data. However, obtaining topological information directly from hyperdigraphs remains a challenge.
Chen, Dong +3 more
openaire +3 more sources
Persistent Homology and Its Applications [PDF]
, 2021 The topological data analysis studies the shape of a space at multiple scales. Its main tool is persistent homology, which is based on other homology theory, usually simplicial homology.
Karvonen, Elli
core
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Multiradial (multi)filtrations and persistent homology [PDF]
, 2016 Motivated by the problem of optimizing sensor network covers, we generalize the persistent homology of simplicial complexes over a single radial parameter to the context of multiple radial parameters.
Martin, Joshua M. +1 more
core
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Applications of Persistent Homology in Nuclear Collisions
, 2022 We introduce a novel set of observables associated to the rapidly developing field of persistent homology for the quantitative characterization of nuclear collisions and their evolution.
Hamilton, Greg +2 more
core +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source