Results 61 to 70 of about 596,197 (256)
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
DCC Workshop on Persistent Identifiers
, 2005 Philip Hunter gives a personal view of this workshop held in Glasgow, 30 June - 1 July, supported by NISO, CETIS, ERPANET, UKOLN and the DCC. The article focuses on a selection of speakers to illustrate the range of the meeting.
Hunter, Philip, Hunter, Philip (5230013)
core +1 more source
EUR Data Coffee Break: Persistent Identifiers
, 2023 A short presentation about Persistent Identifiers (PIDs).
Gulpers, Judith
core +2 more sources
Digital Scholarly Journals Are Poorly Preserved: A Study of 7 Million Articles
Journal of Librarianship and Scholarly CommunicationIntroduction: Digital preservation underpins the persistence of scholarly links and citations through the digital object identifier (DOI) system. We do not currently know, at scale, the extent to which articles assigned a DOI are adequately preserved ...
Martin Paul Eve
doaj +2 more sources
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Persistent Identifiers for Instruments and Facilities: Current State, Challenges, and Opportunities
Journal of eScience LibrarianshipObjective: Persistent Identifiers (PIDs) are central to the vision of open science described in the FAIR Principles. However, the use of PIDs for scientific instruments and facilities is decentralized and fragmented.
Aditya Ranganath +6 more
doaj +2 more sources
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Persistent Identifiers and URLs [PDF]
, 2015 Just like the rest of the internet, much of our scholarly infrastructure is built around the Hypertext Transfer Protocol (HTTP), increasingly HTTPS for security, and soon HTTP/2 for better performance. In this infrastructure Universal Resource Locators (URLs) are essential to locate resources (sic) such as scholarly articles, datasets, researchers ...
openaire +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Persistent Identifiers. Why and how?
Introduction to persistent identifiers for early-career researchers. This presentation introduces the most commonly used types of persistent identifiers, explains their purpose, and shows how to use them effectively in ...
Šilha Machová, Hana, Heringová, Hana
core +2 more sources